scholarly journals CARDIOVASCULAR DISEASE RISK FACTORS IN PATIENTS WITH POSTTRAUMATIC STRESS DISORDER (PTSD): A NARRATIVE REVIEW

2017 ◽  
Vol 29 (4) ◽  
pp. 421-430 ◽  
Author(s):  
Marina Sagud ◽  
◽  
Nenad Jaksic ◽  
Bjanka Vuksan-Cusa ◽  
Mladen Loncar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Narrative Review ◽  
Cardiovascular Disease Risk Factors

Current Posttraumatic Stress Disorder and Cardiovascular Disease Risk Factors in Dutch Resistance Veterans from World War II

1992 ◽  
Vol 57 (4) ◽  
pp. 164-171 ◽  
Author(s):  
Paul R.J. Falger ◽  
Wybrand Op den Velde ◽  
Johannes E. Hovens ◽  
Erik G.W. Schouten ◽  
Johannes H.M. De Groen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Posttraumatic Stress Disorder ◽  
World War Ii ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
World War ◽  
Resistance Veterans

scholarly journals Increased vascular α1-adrenergic receptor sensitivity in older adults with posttraumatic stress disorder

2020 ◽  
Vol 319 (6) ◽  
pp. R611-R616
Author(s):  
Cortnie L. Hartwig ◽  
Justin D. Sprick ◽  
Jinhee Jeong ◽  
Yingtian Hu ◽  
Doree G. Morison ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Sympathetic Nerve ◽  
Stress Disorder ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Blood Pressure Reactivity ◽  
Pressure Reactivity

Posttraumatic stress disorder (PTSD) is an independent risk factor for the development of hypertension and cardiovascular disease. Patients with PTSD have heightened blood pressure and sympathetic nervous system reactivity; however, it is unclear if patients with PTSD have exaggerated vasoconstriction in response to sympathetic nerve activation that could also contribute to increased blood pressure reactivity. Therefore, we hypothesized that patients with PTSD have increased sensitivity of vascular α1-adrenergic receptors (α1ARs), the major mediators of vasoconstriction in response to release of norepinephrine at sympathetic nerve terminals. To assess vascular α1AR sensitivity, we measured the degree of venoconstriction in a dorsal hand vein in response to exponentially increasing doses of the selective α1AR agonist, phenylephrine (PE), in 9 patients with PTSD (age = 59 ± 2 yr) and 10 age-matched controls (age = 60 ± 1 yr). Individual dose-response curves were generated to determine the dose of PE that induces 50% of maximal venoconstriction (i.e., PE ED50) reflective of vascular α1AR sensitivity. In support of our hypothesis, PE ED50 values were lower in PTSD compared with controls (245 ± 54 ng/min vs. 1,995 ± 459 ng/min, P = 0.012), indicating increased vascular α1AR sensitivity in PTSD. The PTSD group also had an increase in slope of rise in venoconstriction, indicative of an altered venoconstrictive reactivity to PE compared with controls (19.8% ± 1.2% vs. 15.1% ± 1.2%, P = 0.009). Heightened vascular α1AR sensitivity in PTSD may contribute to augmented vasoconstriction and blood pressure reactivity to sympathoexcitation and to increased cardiovascular disease risk in this patient population.

The Relationship between Immigration Status and Cardiovascular Disease Risk Factors in United States Adults with Diabetes—A 14-Year Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1491-P
Author(s):  
APRILL DAWSON ◽  
EMMA GARACCI ◽  
MUKOSO N. OZIEH ◽  
REBEKAH J. WALKER ◽  
LEONARD E. EGEDE
Keyword(s):  
United States ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Immigration Status ◽  
The Relationship
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