scholarly journals Differential Expression of Type IV Collagen alpha 1 to alpha 6 Chains in Basement Membrane of Human Tooth Germ and Odontogenic Tumors

2004 ◽  
Vol 13 (3) ◽  
pp. 103-109 ◽  
Author(s):  
Hidetaka Fujii ◽  
Hitoshi Nagatsuka ◽  
You Jin Lee ◽  
Taisei Shinnou ◽  
Ryo Tamamura ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Differential Expression ◽  
Type Iv Collagen ◽  
Tooth Germ ◽  
Odontogenic Tumors ◽  
Human Tooth ◽  
Type Iv ◽  
Human Tooth Germ

Differential expression of basement membrane type IV collagen α chains in gastric intramucosal neoplastic lesions

2007 ◽  
Vol 42 (11) ◽  
pp. 874-880 ◽  
Author(s):  
Yoshifumi Baba ◽  
Ken-ichi Iyama ◽  
Koei Ikeda ◽  
Shinji Ishikawa ◽  
Naoko Hayashi ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Differential Expression ◽  
Type Iv Collagen ◽  
Type Iv ◽  
Neoplastic Lesions ◽  
Membrane Type

scholarly journals Localization of Type IV Collagen Alpha Chains in the Basement Membrane of Ameloblastoma, Tooth Germ and Oral Mucosa by Using Indirect Immunofluorescence.

2005 ◽  
Vol 14 (2) ◽  
pp. 235-236
Author(s):  
Hirokuni Kou ◽  
Silvia Susana Borkosky ◽  
Hitoshi Nagatsuka ◽  
Ryo Tamamura ◽  
Keisuke Nakano ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Oral Mucosa ◽  
Indirect Immunofluorescence ◽  
Type Iv Collagen ◽  
Tooth Germ ◽  
Type Iv

scholarly journals Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Yuexin Wu ◽  
Yuyan Cao ◽  
Keren Xu ◽  
Yue Zhu ◽  
Yuemei Qiao ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Basement Membrane ◽  
Type Iv Collagen ◽  
Patient Survival ◽  
Early Stage ◽  
Ecm Remodeling ◽  
Type Iv ◽  
Ecm Proteins ◽  
Stage Disease ◽  
Cirrhotic Patients

AbstractLiver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease. Liver cirrhosis is the result of deregulated wound healing and is featured by aberrant extracellular matrix (ECM) remodeling. However, it is not comprehensively understood how ECM is dynamically remodeled in the progressive development of liver cirrhosis. It is yet unknown whether ECM signature is of predictive value in determining prognosis of early-stage liver cirrhosis. In this study, we systematically analyzed proteomics of decellularized hepatic matrix and identified four unique clusters of ECM proteins at tissue damage/inflammation, transitional ECM remodeling or fibrogenesis stage in carbon tetrachloride-induced liver fibrosis. In particular, basement membrane (BM) was heavily deposited at the fibrogenesis stage. BM component minor type IV collagen α5 chain expression was increased in activated hepatic stellate cells. Knockout of minor type IV collagen α5 chain ameliorated liver fibrosis by hampering hepatic stellate cell activation and promoting hepatocyte proliferation. ECM signatures were differentially enriched in the biopsies of good and poor prognosis early-stage liver cirrhosis patients. Clusters of ECM proteins responsible for homeostatic remodeling and tissue fibrogenesis, as well as basement membrane signature were significantly associated with disease progression and patient survival. In particular, a 14-gene signature consisting of basement membrane proteins is potent in predicting disease progression and patient survival. Thus, the ECM signatures are potential prognostic biomarkers to identify cirrhotic patients at high risk developing advanced stage disease.

In vitro differentiation of human tooth germ stem cells into endothelial- and epithelial-like cells

2014 ◽  
Vol 39 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Ayşegül Doğan ◽  
Selami Demirci ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
In Vitro Differentiation ◽  
Human Tooth Germ

Isolation and characterization of pepsin-solubilized human basement membrane (type IV) collagen peptides

Biochemistry ◽  
1983 ◽  
Vol 22 (21) ◽  
pp. 4940-4948 ◽  
Author(s):  
Robert S. MacWright ◽  
Virginia A. Benson ◽  
Katherine T. Lovello ◽  
Michel Van der Rest ◽  
Peter P. Fietzek
Keyword(s):  
Basement Membrane ◽  
Type Iv Collagen ◽  
Collagen Peptides ◽  
Type Iv ◽  
Isolation And Characterization ◽  
Membrane Type
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