Newest concepts of physiotherapy research

Physiotherapy ◽  
2013 ◽  
Vol 21 (4) ◽  
Author(s):  
Emilia Wysoczańska ◽  
Anna Skrzek
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Stem Cells ◽  
Back Pain ◽  
Physical Therapy ◽  
Spinal Cord Injuries ◽  
Epidural Stimulation ◽  
The Subject ◽  
Multiple Sclerosis Treatment

AbstractThe subject of the paper is the variety of newest research concepts in the field of physical therapy. The research, which is being conducted worldwide, deals with different issues. Researchers speculate that using stem cells may have considerable significance in treating patients with spinal cord injuries. Another subject of great interest includes studies on spinal cord neuroprosthetics and epidural stimulation. The results show the importance of the newest findings. Moreover, researchers are analysing e.g. the use of cannabinoids in multiple sclerosis treatment or the role of yoga in treating back pain. The results show the diversity of physiotherapy as a field of study.

scholarly journals Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration

2015 ◽  
Vol 2015 ◽  
pp. 1-24 ◽  
Author(s):  
Rita C. Assunção-Silva ◽  
Eduardo D. Gomes ◽  
Nuno Sousa ◽  
Nuno A. Silva ◽  
António J. Salgado
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Survival ◽  
Spinal Cord Injuries ◽  
Human Stem Cells ◽  
Related Disorder ◽  
Cord Injury ◽  
Cell Carriers

Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells. Although promising, cell transplantation is often overturned by the poor cell survival in the treatment of spinal cord injuries. Alternatively, the therapeutic role of different cells has been used in tissue engineering approaches by engrafting cells with biomaterials. The latter have the advantages of physically mimicking the CNS tissue, while promoting a more permissive environment for cell survival, growth, and differentiation. The roles of both cell- and biomaterial-based therapies as single therapeutic approaches for SCI repair will be discussed in this review. Moreover, as the multifactorial inhibitory environment of a SCI suggests that combinatorial approaches would be more effective, the importance of using biomaterials as cell carriers will be herein highlighted, as well as the recent advances and achievements of these promising tools for neural tissue regeneration.

scholarly journals A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4930
Author(s):  
Éamon Jones ◽  
Styliani Vlachou
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Animal Models ◽  
Receptor Agonist ◽  
Double Blind ◽  
Cannabinoid Compounds ◽  
Adrenergic Receptor Agonist ◽  
Multiple Sclerosis Treatment

Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease. In line with this, Sativex, a synthetic combination of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (Δ9-THC) has been approved to treat symptoms of spasticity. In animals, CBD is effective in reducing the amounts of T-cell infiltrates in the spinal cord, suggesting CBD has anti-inflammatory properties. By doing this, CBD has shown to delay symptom onset in animal models of multiple sclerosis and slow disease progression. Importantly, combinations of CBD and Δ9-THC appear more effective in treating animal models of multiple sclerosis. While CBD reduces the amounts of cell infiltrates in the spinal cord, Δ9-THC reduces scores of spasticity. In human studies, the results are less encouraging and conflict with the findings in animals. Drugs which deliver a combination of Δ9-THC and CBD in a 1:1 ratio appear to be only moderately effective in reducing spasticity scores, but appear to be almost as effective as current front-line treatments and cause less severe side effects than other treatments, such as baclofen (a GABA-B receptor agonist) and tizanidine (an α2 adrenergic receptor agonist). The findings of the studies reviewed suggest that cannabinoids may help treat neuropathic pain in pwMS as an add-on therapy to already established pain treatments. It is important to note that treatment with cannabinoid compounds may cause significant cognitive dysfunction. Long term double-blind placebo studies are greatly needed to further our understanding of the role of cannabinoids in multiple sclerosis treatment.

scholarly journals Exoskeletons, Rehabilitation and Bodily Capacities

2021 ◽  
pp. 1357034X2110256
Author(s):  
Denisa Butnaru
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Crucial Role ◽  
Spinal Cord Injuries ◽  
Main Task ◽  
Cerebrovascular Accidents ◽  
Complex Processes ◽  
Cord Injury ◽  
Neurological Conditions

Motility impairments resulting from spinal cord injuries and cerebrovascular accidents are increasingly prevalent in society, leading to the growing development of rehabilitative robotic technologies, among them exoskeletons. This article outlines how bodies with neurological conditions such as spinal cord injury and stroke engage in processes of re-appropriation while using exoskeletons and some of the challenges they face. The main task of exoskeletons in rehabilitative environments is either to rehabilitate or ameliorate anatomic functions of impaired bodies. In these complex processes, they also play a crucial role in recasting specific corporeal phenomenologies. For the accomplishment of these forms of corporeal re-appropriation, the role of experts is crucial. This article explores how categories such as bodily resistance, techno-inter-corporeal co-production of bodies and machines, as well as body work mark the landscape of these contemporary forms of impaired corporeality. While defending corporeal extension rather than incorporation, I argue against the figure of the ‘cyborg’ and posit the idea of ‘residual subjectivity’.

scholarly journals Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?

Stem Cells ◽  
2014 ◽  
Vol 32 (4) ◽  
pp. 829-843 ◽  
Author(s):  
Virginie Neirinckx ◽  
Dorothée Cantinieaux ◽  
Cécile Coste ◽  
Bernard Rogister ◽  
Rachelle Franzen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Crest ◽  
Spinal Cord Injuries ◽  
Neural Crest Stem Cells ◽  
Concise Review

scholarly journals Corrigendum to “Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries”

2017 ◽  
Vol 2017 ◽  
pp. 1-1 ◽  
Author(s):  
Anna Zadroga ◽  
Katarzyna Jezierska-Woźniak ◽  
Joanna Czarzasta ◽  
Monika Barczewska ◽  
Joanna Wojtkiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Spinal Cord Injuries ◽  
Therapeutic Potential ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

Stem cells and spinal-cord injuries: an intricate issue

Nature ◽  
2021 ◽  
Vol 597 (7878) ◽  
pp. S11-S11
Author(s):  
Lauren Gravitz
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injuries

Tissue regeneration and repair in multiple sclerosis: the role of neural stem cells

2011 ◽  
pp. 60-66
Author(s):  
Stefano Pluchino ◽  
Roberto Furlan ◽  
Luca Muzio ◽  
Gianvito Martino
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Tissue Regeneration
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