scholarly journals Analysis of Menthol, Menthol-Like, and Other Tobacco Flavoring Compounds in Cigarettes and in Electrically Heated Tobacco Products

2018 ◽  
Vol 28 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Lea Reger ◽  
Julia Moß ◽  
Harald Hahn ◽  
Jürgen Hahn
Keyword(s):  
Mass Spectrometry ◽  
The United States ◽  
Social Recognition ◽  
German Market ◽  
Tobacco Products ◽  
Cooling Agent ◽  
Menthol Cigarettes ◽  
Huge Variety ◽  
The Eu

SummaryAlthough smoking is responsible for a huge variety of diseases which result in ~16% of the fatalities in the United States and Europe respectively, cigarettes are still being sold far and wide. Mentholated cigarettes were introduced in 1920, since then to today social recognition and the use of flavored tobacco products is still increasing especially within young people. The EU adopted as its measure to reduce tobacco use among adolescents the prohibition of tobacco products with a characteristic flavor by means of the directive 2014/40/EU of the European Parliament and the Council.For this reason, we developed a method for the simultaneous determination of 14 tobacco flavors like menthol, menthol-like and other compounds via gas-chromatography coupled with mass-spectrometry (GC/MS) and analyzed 21 different tobacco products (mentholated and non-mentholated cigarettes, as well as electrically heated tobacco products (EHTPs)) of the German market regarding their flavoring compound patterns. The highest amounts of flavoring compounds were determined in menthol cigarettes (~10,000 μg/stick) whereas non-mentholated cigarettes and EHTPs featured only ~10 μg/stick. In total, seven flavoring compounds like menthol, L-menthone, L-linalool, isopulegol, geraniol, camphor and WS-3 (cooling agent) were available within the samples. Mentholated cigarettes could be clearly identified since > 99% of the measured flavoring compounds was represented by menthol. Although flavoring compounds in non-mentholated cigarettes and EHTPs were quite comparable, they could be differentiated due to different flavoring compound patterns. Brandspecific flavoring compound patterns were not recognized.

scholarly journals Determination of N-Nitrosamines by Gas Chromatography Coupled to Quadrupole–Time-of-Flight Mass Spectrometry in Water Samples

Separations ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. 3 ◽  
Author(s):  
Benigno José Sieira ◽  
Inmaculada Carpinteiro ◽  
Rosario Rodil ◽  
José Benito Quintana ◽  
Rafael Cela
Keyword(s):  
Mass Spectrometry ◽  
Environmental Protection Agency ◽  
Ion Trap ◽  
Solid Phase ◽  
Classical Method ◽  
Tap Water ◽  
Time Of Flight ◽  
The United States ◽  
Mass Analyzer

An analytical method based on high-resolution quadrupole–time-of-flight (QToF) mass spectrometry has been developed as an alternative to the classical method, using a low-resolution ion trap (IT) analyzer to reduce interferences in N-nitrosamines determination. Extraction of the targeted compounds was performed by solid-phase extraction (SPE) following the United States Environmental Protection Agency (USEPA) -521 method. First, both electron impact (EI) and positive chemical ionization (PCI) using methane as ionization gas were compared, along with IT and QToF detection. Then, parameters such as limits of detection (LOD) and quantification (LOQ), linearity, and repeatability were assessed. The results showed that the QToF mass analyzer combined with PCI was the best system for the determination of the N-nitrosamines, with instrumental LOD and LOQ in the ranges of 0.2–4 and 0.6–11 ng mL−1, respectively, which translated into method LOD and LOQ in the ranges of 0.2–1.3 and 0.6–3.9 ng L−1, respectively. The analysis of real samples showed the presence of 6 of the N-nitrosamines in influent, effluent, and tap water. N-nitrosodimethylamine (NDMA) was quantified in all the analyzed samples at concentrations between 1 and 27 ng L−1. Moreover, four additional nitrosamines were found in tap and wastewater samples.

Multi-class pesticide determination in royal jelly by gas chromatography coupled to triple quadrupole tandem mass spectrometry

2014 ◽  
Vol 6 (14) ◽  
pp. 5376-5386 ◽  
Author(s):  
Gerardo Martínez-Domínguez ◽  
Roberto Romero-González ◽  
Antonia Garrido-Frenich
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Tandem Mass Spectrometry ◽  
Royal Jelly ◽  
Tandem Mass ◽  
Triple Quadrupole ◽  
The Eu

Determination of pesticides in royal jelly, below the MRLs established by the EU, using SPE and GC-QqQ-MS/MS.

scholarly journals Determination of Volatile N-Nitrosamines in the Vapour Phase of the Smoke from Various Tobacco Products

1975 ◽  
Vol 8 (3) ◽  
Author(s):  
P.J. Groenen ◽  
M.C. ten Noever de Brauw
Keyword(s):  
Mass Spectrometry ◽  
Vapour Phase ◽  
Tobacco Products ◽  
Flame Ionization ◽  
Capillary Glc ◽  
The One ◽  
The Individual ◽  
Positive Results ◽  
Whole Smoke

AbstractVolatile N-nitrosamines were determined in the vapour phase of tobacco smoke after accumulation of Iarge vapour samples on to a cooled capillary GLC column. Detection was effected by computerized mass spectrometry and by a nitrogen-specific detector. Five different tobacco products were studied with mass spectrometry for the presence of eight individuaI nitrosamines. The result was negative thirty-nine times and positive only once. Initially, the detection Iimit for the individual nitrosamines was 2 ng per 20-55 mI vapour injection; during this study the effective detection limit was Iowered for some of the compounds by a further twofold to fivefold increase of the vapour volume analysed. The one nitroso compound identified positively and unambiguously was N-nitrosopiperidine in the smoke from the American blend cigarettes. It amounted to about 5.6 ng in the vapour phase of the smoke of one cigarette. The partition of nitrosamines between vapour phase and particulate phase is not known, but amounts of more than 1 µg of dimethylnitrosamine or nitrosopiperidine in the whole smoke of one cigarette as found by some authors, seem improbably high. It is shown in this paper that exclusive use of the alkali flame ionization detector for nitrosamine determinations would have led to false-positive results, especially for dimethylnitrosamine.

Overview of the Chromatographic and Mass Spectrometry Analytical Methods for Determination of Lamivudine in Biological Fluids

2019 ◽  
Vol 15 (2) ◽  
pp. 103-108
Author(s):  
Xuwang Chen ◽  
Fanlong Bu ◽  
Rong Li ◽  
Guiyan Yuan ◽  
Yanyan Wang ◽  
...  
Keyword(s):  
United States ◽  
Mass Spectrometry ◽  
Clinical Practice ◽  
Analytical Methods ◽  
Review Paper ◽  
Biological Fluids ◽  
Animal Experiments ◽  
The United States ◽  
Therapeutic Drug

Background: Lamivudine was approved by Food and Drug Administration of the United States for the treatment of both HIV and HBV infection, which has been widely used as monotherapy or a component of combination therapy in clinics in many countries and nationalities. Methods: In this paper, the recent chromatographic and mass spectrometry analytical methods for the determination of lamivudine individually or combination with other drugs simultaneously were presented. These methods were widely applied in pharmacokinetics studies, bioequivalence studies, therapeutic drug monitoring studies, cell and animal experiments. Conclusion: The review paper might provide references for determining lamivudine in biological fluids, the intracorporal process of lamivudine, and the clinical practice by monitoring plasma concentration of lamivudine in the future.

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