scholarly journals Biocomputing, Biosensing and Bioactuation Based on Enzyme Biocatalyzed Reactions

Biocatalysis ◽  
2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Shay Mailloux ◽  
Evgeny Katz
Keyword(s):  
Review Paper ◽  
Biomolecular Computing ◽  
Triggered Release ◽  
Bioactive Substances ◽  
Responsive Materials ◽  
Autonomous Operation ◽  
Multiple Components ◽  
Working Together ◽  
Chemical Inputs ◽  
Biochemical Signals

AbstractThe focus of this review paper is on the design and implementation of smart ‘Sense-and-Treat’ systems using enzyme-biocatalytic systems. These systems were used to perform biomolecular computing and they were functionally integrated with signal responsive materials aiming towards their biomedical use. Electrode interfaces, functionalized with signal-responsive materials, find applications in biocomputing, biosensing, and, specifically, triggered release of bioactive substances. ‘Sense-and-Treat’ systems require multiple components working together, including biosensors, actuators, and filters, in order to achieve closed-loop and autonomous operation. In general, biochemical logic networks were developed to process single biochemical or chemical inputs as well as multiple inputs, responding to nonphysiological (for concept demonstration purposes) and physiological signals (for injury detection or diagnosis). Actuation of drug-mimicking release was performed using the responsive material iron-cross-linked alginate with entrapped biomolecular species, responding to physical, chemical or biochemical signals.

scholarly journals Hardware Methods for Onboard Control of Fluidically Actuated Soft Robots

2021 ◽  
Vol 8 ◽  
Author(s):  
Kevin McDonald ◽  
Tommaso Ranzani
Keyword(s):  
Degrees Of Freedom ◽  
Review Paper ◽  
State Of The Art ◽  
Human Interaction ◽  
Power Delivery ◽  
Soft Robots ◽  
Integrate Control ◽  
Working Together ◽  
Multiple Actuators ◽  
Reaction Speed

Soft robots provide significant advantages over their rigid counterparts. These compliant, dexterous devices can navigate delicate environments with ease without damage to themselves or their surroundings. With many degrees of freedom, a single soft robotic actuator can achieve configurations that would be very challenging to obtain when using a rigid linkage. Because of these qualities, soft robots are well suited for human interaction. While there are many types of soft robot actuation, the most common type is fluidic actuation, where a pressurized fluid is used to inflate the device, causing bending or some other deformation. This affords advantages with regards to size, ease of manufacturing, and power delivery, but can pose issues when it comes to controlling the robot. Any device capable of complex tasks such as navigation requires multiple actuators working together. Traditionally, these have each required their own mechanism outside of the robot to control the pressure within. Beyond the limitations on autonomy that such a benchtop controller induces, the tether of tubing connecting the robot to its controller can increase stiffness, reduce reaction speed, and hinder miniaturization. Recently, a variety of techniques have been used to integrate control hardware into soft fluidic robots. These methods are varied and draw from disciplines including microfluidics, digital logic, and material science. In this review paper, we discuss the state of the art of onboard control hardware for soft fluidic robots with an emphasis on novel valve designs, including an overview of the prevailing techniques, how they differ, and how they compare to each other. We also define metrics to guide our comparison and discussion. Since the uses for soft robots can be so varied, the control system for one robot may very likely be inappropriate for use in another. We therefore wish to give an appreciation for the breadth of options available to soft roboticists today.

scholarly journals DNA-assembled nanoarchitectures with multiple components in regulated and coordinated motion

2019 ◽  
Vol 5 (11) ◽  
pp. eaax6023 ◽  
Author(s):  
Pengfei Zhan ◽  
Maximilian J. Urban ◽  
Steffen Both ◽  
Xiaoyang Duan ◽  
Anton Kuzyk ◽  
...  
Keyword(s):  
Building Blocks ◽  
Dna Origami ◽  
Joint Motion ◽  
Coordinated Motion ◽  
Gold Nanocrystals ◽  
Multiple Components ◽  
Working Together ◽  
Gear Trains ◽  
Biological Entities

Coordinating functional parts to operate in concert is essential for machinery. In gear trains, meshed gears are compactly interlocked, working together to impose rotation or translation. In photosynthetic systems, a variety of biological entities in the thylakoid membrane interact with each other, converting light energy into chemical energy. However, coordinating individual parts to carry out regulated and coordinated motion within an artificial nanoarchitecture poses challenges, owing to the requisite control on the nanoscale. Here, we demonstrate DNA-directed nanosystems, which comprise hierarchically-assembled DNA origami filaments, fluorophores, and gold nanocrystals. These individual building blocks can execute independent, synchronous, or joint motion upon external inputs. These are optically monitored in situ using fluorescence spectroscopy, taking advantage of the sensitive distance-dependent interactions between the gold nanocrystals and fluorophores positioned on the DNA origami. Our work leverages the complexity of DNA-based artificial nanosystems with tailored dynamic functionality, representing a viable route towards technomimetic nanomachinery.

scholarly journals Biomolecular Release from Alginate-modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade - Integration of Biomolecular Computing and Actuation

2017 ◽  
Vol 30 (3) ◽  
pp. 426-435 ◽  
Author(s):  
Andrey V. Okhokhonin ◽  
Sergii Domanskyi ◽  
Yaroslav Filipov ◽  
Maria Gamella ◽  
Alisa N. Kozitsina ◽  
...  
Keyword(s):  
Modified Electrode ◽  
Biomolecular Computing ◽  
Chemical Inputs

scholarly journals Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 65
Author(s):  
Ivan A. Burmistrov ◽  
Maxim M. Veselov ◽  
Alexander V. Mikheev ◽  
Tatiana N. Borodina ◽  
Tatiana V. Bukreeva ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Targeted Delivery ◽  
Low Frequency ◽  
Triggered Release ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Bioactive Substances ◽  
Polyelectrolyte Microcapsules ◽  
Penetration Ability ◽  
Frequency Magnetic Field

Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.

Identifying suboptimalities with factorial model comparison

2018 ◽  
Vol 41 ◽  
Author(s):  
Wei Ji Ma
Keyword(s):  
Experimental Design ◽  
Model Comparison ◽  
Process Models ◽  
Multiple Forms ◽  
Factorial Experimental Design ◽  
Factorial Model ◽  
Multiple Components ◽  
The Many

AbstractGiven the many types of suboptimality in perception, I ask how one should test for multiple forms of suboptimality at the same time – or, more generally, how one should compare process models that can differ in any or all of the multiple components. In analogy to factorial experimental design, I advocate for factorial model comparison.

Statistics and parallaxes

1978 ◽  
Vol 48 ◽  
pp. 7-29
Author(s):  
T. E. Lutz
Keyword(s):  
Experimental Design ◽  
Statistical Methods ◽  
Review Paper ◽  
Systematic Errors ◽  
Past Experience ◽  
Random Errors ◽  
Trigonometric Parallaxes ◽  
Systematic And Random Errors

This review paper deals with the use of statistical methods to evaluate systematic and random errors associated with trigonometric parallaxes. First, systematic errors which arise when using trigonometric parallaxes to calibrate luminosity systems are discussed. Next, determination of the external errors of parallax measurement are reviewed. Observatory corrections are discussed. Schilt’s point, that as the causes of these systematic differences between observatories are not known the computed corrections can not be applied appropriately, is emphasized. However, modern parallax work is sufficiently accurate that it is necessary to determine observatory corrections if full use is to be made of the potential precision of the data. To this end, it is suggested that a prior experimental design is required. Past experience has shown that accidental overlap of observing programs will not suffice to determine observatory corrections which are meaningful.

Project BRAIN: Working Together to Improve Educational Outcomes for Students With Traumatic Brain Injury

2012 ◽  
Vol 22 (3) ◽  
pp. 106-118 ◽  
Author(s):  
Paula Denslow ◽  
Jean Doster ◽  
Kristin King ◽  
Jennifer Rayman
Keyword(s):  
Traumatic Brain Injury ◽  
At Risk ◽  
Brain Injury ◽  
Educational Outcomes ◽  
School Personnel ◽  
Department Of Education ◽  
Health Providers ◽  
Accurate Identification ◽  
Transition Intervention ◽  
Working Together

Children and youth who sustain traumatic brain injury (TBI) are at risk for being unidentified or misidentified and, even if appropriately identified, are at risk of encountering professionals who are ill-equipped to address their unique needs. A comparison of the number of people in Tennessee ages 3–21 years incurring brain injury compared to the number of students ages 3–21 years being categorized and served as TBI by the Department of Education (DOE) motivated us to create this program. Identified needs addressed by the program include the following: (a) accurate identification of students with TBI; (b) training of school personnel; (c) development of linkages and training of hospital personnel; and (d) hospital-school transition intervention. Funded by Health Services and Resources Administration (HRSA) grants with support from the Tennessee DOE, Project BRAIN focuses on improving educational outcomes for students with TBI through the provision of specialized group training and ongoing education for educators, families, and health professionals who support students with TBI. The program seeks to link families, hospitals, and community health providers with school professionals such as speech-language pathologists (SLPs) to identify and address the needs of students with brain injury.

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

2016 ◽  
Vol 86 (3-4) ◽  
pp. 127-151 ◽  
Author(s):  
Zeshan Ali ◽  
Zhenbin Wang ◽  
Rai Muhammad Amir ◽  
Shoaib Younas ◽  
Asif Wali ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Review Paper ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Active Role ◽  
Current Review ◽  
Different Types ◽  
Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

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