scholarly journals Imaging of M^|^eacute;ni^|^egrave;re's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Subtraction Images with Different Inversion Time

2012 ◽  
Vol 11 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Shinji NAGANAWA ◽  
Masahiro YAMAZAKI ◽  
Hisashi KAWAI ◽  
Kiminori BOKURA ◽  
Michihiko SONE ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Inversion Time

Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration

1986 ◽  
Vol 13 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Agneta Ohlsson ◽  
Jan-Erik Lindgren ◽  
Susanne Andersson ◽  
Stig Agurell ◽  
Hampton Gillespie ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Kinetics Of

scholarly journals A dose-ranging pharmacokinetic study of nicotine tartrate following single-dose delayed-release oral and intravenous administration

1997 ◽  
Vol 11 (5) ◽  
pp. 865-874 ◽  
Author(s):  
R. F. COMPTON ◽  
W. J. SANDBORN ◽  
G. M. LAWSON ◽  
A. J. SHEETS ◽  
D. C. MAYS ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Pharmacokinetic Study ◽  
Delayed Release ◽  
Dose Ranging

The Single-Dose Pharmacokinetics of Midazolam and Its Primary Metabolite in Pediatric Patients after Oral and Intravenous Administration

2001 ◽  
Vol 41 (12) ◽  
pp. 1359-1369 ◽  
Author(s):  
Michael D. Reed ◽  
Alexander Rodarte ◽  
Jeffrey L. Blumer ◽  
Ko-Chin Khoo ◽  
Bardia Akbari ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Pediatric Patients ◽  
Primary Metabolite

scholarly journals A Metabolomic Approach for the In Vivo Study of Gold Nanospheres and Nanostars after a Single-Dose Intravenous Administration to Wistar Rats

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1606 ◽  
Author(s):  
Enea ◽  
Araújo ◽  
Almeida ◽  
Soares ◽  
Gonçalves-Monteiro ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Wistar Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Gold Nanospheres ◽  
Gold Nanostars ◽  
Different Types ◽  
Metabolomic Approach

Gold nanoparticles (AuNPs) are promising nanoplatforms for drug therapy, diagnostic and imaging. However, biological comparison studies for different types of AuNPs fail in consistency due to the lack of sensitive methods to detect subtle differences in the expression of toxicity. Therefore, innovative and sensitive approaches such as metabolomics are much needed to discriminate toxicity, specially at low doses. The current work aims to compare the in vivo toxicological effects of gold nanospheres versus gold nanostars (of similar ~40 nm diameter and coated with 11-mercaptoundecanoic acid) 24 h after an intravenous administration of a single dose (1.33 × 1011 AuNPs/kg) to Wistar rats. The biodistribution of both types of AuNPs was determined by graphite furnace atomic absorption spectroscopy. The metabolic effects of the AuNPs on their main target organ, the liver, were analyzed using a GC-MS-based metabolomic approach. Conventional toxicological endpoints, including the levels of ATP and reduced and oxidized glutathione, were also investigated. The results show that AuNPs preferentially accumulate in the liver and, to a lesser extent, in the spleen and lungs. In other organs (kidney, heart, brain), Au content was below the limit of quantification. Reduced glutathione levels increased for both nanospheres and nanostars in the liver, but ATP levels were unaltered. Multivariate analysis showed a good discrimination between the two types of AuNPs (sphere- versus star-shaped nanoparticles) and compared to control group. The metabolic pathways involved in the discrimination were associated with the metabolism of fatty acids, pyrimidine and purine, arachidonic acid, biotin, glycine and synthesis of amino acids. In conclusion, the biodistribution, toxicological, and metabolic profiles of gold nanospheres and gold nanostars were described. Metabolomics proved to be a very useful tool for the comparative study of different types of AuNPs and raised awareness about the pathways associated to their distinct biological effects.

Intravenous Administration of a Single-Dose Free-Circulating DNA of Colitic Origin Improves Severe Murine DSS-Colitis

2014 ◽  
Vol 20 (4) ◽  
pp. 867-877 ◽  
Author(s):  
Ferenc Sipos ◽  
Györgyi Műzes ◽  
István Fűri ◽  
Sándor Spisák ◽  
Barnabás Wichmann ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Circulating Dna ◽  
Dss Colitis ◽  
Free Circulating Dna

Marbofloxacin Disposition After Intravenous Administration of a Single Dose in Wild Mallard Ducks (Anas platyrhynchos)

2012 ◽  
Vol 26 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Marino Garcia-Montijano ◽  
J. Julio de Lucas ◽  
Casilda Rodríguez ◽  
Fernando González ◽  
Manuel Ignacio San Andrés ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Anas Platyrhynchos ◽  
Wild Mallard
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