Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease

2006 ◽  
Vol 67 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Jonathan M. Levine ◽  
Craig G. Ruaux ◽  
Robert L. Bergman ◽  
Joan R. Coates ◽  
Jörg M. Steiner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinase ◽  
Intervertebral Disk ◽  
Matrix Metalloproteinase 9 ◽  
Spinal Cord Trauma ◽  
Metalloproteinase 9

scholarly journals Assessment of Nogo-66 Receptor 1 Function In Vivo After Spinal Cord Injury

Neurosurgery ◽  
2014 ◽  
Vol 75 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Jing Tong ◽  
Yi Ren ◽  
Xiaowei Wang ◽  
Vassilios G. Dimopoulos ◽  
Henry N. Kesler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Matrix Metalloproteinase ◽  
Functional Recovery ◽  
Axon Regeneration ◽  
Matrix Metalloproteinase 9 ◽  
Mutant Mice ◽  
Locomotor Function ◽  
Cord Injury ◽  
Metalloproteinase 9

Abstract BACKGROUND: Neuronal Nogo-66 receptor 1 (NgR1) has attracted attention as a converging point for mediating the effects of myelin-associate inhibitory ligands in the central nervous system, establishing the growth-restrictive environment, and limiting axon regeneration after traumatic injury. OBJECTIVE: To investigate the factors that may be contributing to the discrepancy in the importance of NgR1, which has been undermined by several studies that have shown the lack of substantial axon regeneration after spinal cord injury (SCI) in NgR1-knockout or -knockdown animal models. METHODS: We used mice carrying either a homozygous or heterozygous null mutation in the NgR1 gene and subjected them to either a moderate or severe SCI. RESULTS: Locomotor function assessments revealed that the level of functional recovery is affected by the degree of injury suffered. NgR1 ablation enhanced local collateral sprouting in the mutant mice. Reactive astrocytes and chondroitin sulfate proteoglycans (CSPGs) are upregulated surrounding the injury site. Matrix metalloproteinase-9, which has been shown to degrade CSPGs, was significantly upregulated in the homozygous mutant mice compared with the heterozygous or wild-type mice. However, CSPG levels remained higher in the homozygous compared with the heterozygous mice, suggesting that CSPG-degrading activity of matrix metalloproteinase-9 may require the presence of NgR1. CONCLUSION: Genetic ablation of NgR1 may lead to significant recovery in locomotor function after SCI. The difference in locomotor recovery we observed between the groups that suffered various degrees of injury suggests that injury severity may be a confounding factor in functional recovery after SCI.

Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis

Cytokine ◽  
2010 ◽  
Vol 51 (3) ◽  
pp. 294-297 ◽  
Author(s):  
Oranuch Sanpool ◽  
Pewpan M. Intapan ◽  
Tongjit Thanchomnang ◽  
Taweesak Santivarangkana ◽  
Kanigar Niwattayakul ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinase ◽  
Plasminogen Activator ◽  
Matrix Metalloproteinase 9 ◽  
Eosinophilic Meningitis ◽  
Metalloproteinase 9

scholarly journals Cerebrospinal Fluid Matrix Metalloproteinase-9 Level in Children with Bacterial Meningitis

2017 ◽  
Vol 63 (1) ◽  
pp. 29-33
Author(s):  
AYAKO TSUMITA ◽  
KAORU OBINATA ◽  
SHIGEAKI INOUE ◽  
TOMOYUKI NAKAZAWA ◽  
KENICHIRO KANEKO ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count

2000 ◽  
Vol 110 (1-2) ◽  
pp. 244-251 ◽  
Author(s):  
Maryna Yushchenko ◽  
Frank Weber ◽  
Michael Mäder ◽  
Ulrike Schöll ◽  
Malgorzata Maliszewska ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinase ◽  
Cell Count ◽  
Matrix Metalloproteinase 9 ◽  
Human Cerebrospinal Fluid ◽  
Metalloproteinase 9
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