scholarly journals Psychiatric Aspects of Epilepsy

2021 ◽  
Vol 03 (3&4) ◽  
pp. 15-20
Author(s):  
Surabhi Sharma ◽  
Keyword(s):  
Psychiatric Comorbidity ◽  
Seizure Control ◽  
Early Recognition ◽  
Holistic Approach ◽  
Brain Regions ◽  
Seizure Threshold ◽  
Neurological Functioning ◽  
Patients With Epilepsy ◽  
The Brain

A seizure is defined as transient change in neurological functioning which is characterised by hypersynchronous discharges of neurons in the brain regions whereas epilepsy is defined as a syndrome consisting of various recurrent seizures and it is associated with the psychological and neuropathological effects. Early recognition and management of psychiatric disorders in patients with epilepsy is extremely important, because it improves the quality of life and aids in better seizure control. Newer antiepileptics with less interaction with psychotropics and less behavioural manifestations should be used for management of epilepsy; and psychotropics having low potential for lowering seizure threshold are generally preferred. A holistic approach to assess psychiatric comorbidity and judicious use of medicine can help in comprehensive patient care planning and reduced health burden.

scholarly journals The effects of epileptic seizures upon quality of life

2009 ◽  
Vol 15 (3) ◽  
pp. 110-113 ◽  
Author(s):  
Priscila Camile Barioni Salgado ◽  
Fernando Cendes
Keyword(s):  
Quality Of Life ◽  
Seizure Frequency ◽  
Seizure Control ◽  
Epileptic Seizures ◽  
Anxiety And Depression ◽  
Co Morbidity ◽  
Item Quality ◽  
Patients With Epilepsy ◽  
And Control

OBJECTIVE: understand the psychological considerations of the relationship between the effect of seizures upon the patients' perception of seizure control, depression, anxiety and quality of life (QoL). METHODS: 151 adult patients with epilepsy diagnosed for over two years were interviewed and responded the 31-Item Quality of Life in Epilepsy (QOLIE-31), the Trait Form of the State/Trait Anxiety Inventory (STAI II) and the Beck Depression Inventory (BDI). RESULTS: 45 patients were depressed (29.8%) and 29 (19.2%) had anxiety. Depression scores ranged from 0 to 49 (M=7.4; SD=8.9) and anxiety scores ranged from 19 to 69 (M=41.5, SD=11.9). Total QoL score was correlated to seizure control (p<0.001), perception of epilepsy control (p<0.001), anxiety (p<0.001), and depression (p=0.003). The perception of epilepsy control was correlated to seizure control (p<0.001), seizure frequency (p=0.001), anxiety (p<0.001) and depression (p<0.001). Seizure control was associated to anxiety (p=0.033) and depression (p<0.001). There was co-morbidity between anxiety and depression (p<0.001). CONCLUSION: This study highlights the importance of the seizure frequency and control to the evaluation of perception of epilepsy control and shows that anxiety and depression in epilepsy are predicted by seizure-related (seizure frequency and control) and psychosocial aspects (perception of control and QoL) together.

PECULIARITIES OF MOTIVATION-NEEDED SPHERE OF PATIENTS WITH EPILEPSY: CLINICAL AND PSYCHOLOGICAL ASPECT

2021 ◽  
pp. 103-109
Author(s):  
Tokareva N.G. ◽  
Ignatieva O.I.
Keyword(s):  
Psychological Research ◽  
Simple Complex ◽  
Complex Partial Seizures ◽  
Prophylactic Measures ◽  
Change Motivation ◽  
Patient Will ◽  
Quality Of Medical Care ◽  
Patients With Epilepsy ◽  
The Brain

Epilepsy is a common neuropsychiatric disease in which a number of personality characteristics change. Motivation takes one of the main places in the structure of the patient's personality. Motivation largely determines human behavior, is an important component, since it helps to understand the features and directions of human activity. A motive is an impulse to activity, which is associated with the goal of satisfying the arisen desires. Only by understanding how the patient's motivational-need sphere is arranged, it is possible to determine the patient's role, the degree of his participation in treatment-and-prophylactic measures, as well as influence the formation of motivation, motivate the sick person for educational activities, labor, production activities, etc. The study of the characteristics of the patient's motivational-need sphere is necessary in order to understand how the patient's motivation is formed in the treatment process, how important it is in his life and whether the patient will be able to effectively manage life, enjoy reality, successfully look and plan the future, precisely based on his own motive. That is why the problem of motivation is very relevant at the present time. This work analyzes the features of the motivational-need-related sphere of patients with epilepsy. The study included 317 patients aged 18 to 65 years with focal forms of epilepsy, whose structure was dominated by simple, complex partial seizures. Verification of the diagnosis in the examined patients was carried out on the basis of the results of clinical neurological, psychopathological, pathopsychological, electroencephalographic examination and computed tomography of the brain. The study used a methodology for assessing the level of claims: V. Gerbachevsky's questionnaire. Clinical and psychological research of patients with epilepsy made it possible to substantiate the choice of 2 clusters: the first cluster included able-bodied working patients – n=131 (41.3%), the second cluster - non-working patients – n=186 (58.7%). In the 1st cluster, indicators on the scales "Level of mobilization of efforts", "Regularity of results", "Cognitive motive" prevail, in the 2nd cluster indicators on the scale "Avoidance" prevail. Taking into account the motivational-need-oriented orientation of the patient is an important component in the construction of therapeutic programs aimed at improving the quality of medical care.

Exploring Ripple Waves in the Human Brain

2021 ◽  
pp. 155005942110343
Author(s):  
Shunsuke Takagi
Keyword(s):  
Memory Function ◽  
Brain Regions ◽  
Sharp Waves ◽  
Neural Activities ◽  
Human Hippocampus ◽  
Electrode Recording ◽  
Intracranial Recording ◽  
Patients With Epilepsy ◽  
The Brain ◽  
High Frequency Oscillatory

Ripples are brief (<150 ms) high-frequency oscillatory neural activities in the brain with a range of 140 to 200 Hz in rodents and 80 to 140 Hz in humans. Ripples are regarded as playing an essential role in several aspects of memory function, mainly in the hippocampus. This type of ripple generally occurs with sharp waves and is called a sharp-wave ripple (SPW-R). Extensive research of SPW-Rs in the rodent brain while actively awake has also linked the function of these SPW-Rs to navigation and decision making. Although many studies with rodents unveiled SPW-R function, research in humans on this subject is still sparse. Therefore, unveiling SPW-R function in the human hippocampus is warranted. A certain type of ripples may also be a biomarker of epilepsy. This type of ripple is called a pathological ripple (p-ripple). p-ripples have a wider range of frequency (80-500 Hz) than SPW-Rs, and the range of frequency is especially higher in brain regions that are intrinsically linked to epilepsy onset. Brain regions producing ripples are too small for scalp electrode recording, and intracranial recording is typically needed to detect ripples. In addition, SPW-Rs in the human hippocampus have been recorded from patients with epilepsy who may have p-ripples. Differentiating SPW-Rs and p-ripples is often not easy. We need to develop more sophisticated methods to record SPW-Rs to differentiate them from p-ripples. This paper reviews the general features and roles of ripple waves.

scholarly journals Medicinal Marijuana for Epilepsy: A Case Series Study

2014 ◽  
Vol 41 (6) ◽  
pp. 753-758 ◽  
Author(s):  
Lady Diana Ladino ◽  
Lizbeth Hernández-Ronquillo ◽  
José Francisco Téllez-Zenteno
Keyword(s):  
Psychiatric Comorbidity ◽  
Seizure Control ◽  
Previous History ◽  
Case Series ◽  
Tobacco Consumption ◽  
Drug Resistant ◽  
Concurrent Use ◽  
Case Series Study ◽  
Drug Resistant Epilepsy ◽  
Patients With Epilepsy

AbstractObjective:To describe the social, clinical and use-patterns characteristics of medicinal marijuana use among patients with epilepsy (PWEs).Methods:Eighteen PWEs with prescriptions for medicinal marijuana from a Canadian adult-epilepsy clinic were included in this study.Results:Eighteen patients had a prescription of medicinal marijuana from a total population of 800 PWEs in our center (2.2%). Mean age of patients was 30±7.4 (19-50) years. Twelve (67%) patients were males. Eleven (61%) patients had drug-resistant epilepsy. Eleven (61%) patients suffered a psychiatric comorbidity and reported the use of illicit substances or heavy alcohol or tobacco consumption. Only two (11%) patients were married; the rest of patients (89%) were single or divorced. The drug use pattern was similar among patients. All patients asked for marijuana permission in the epilepsy clinic. Most (83%) had a previous history of marijuana smoking, with a mean of 6.6±3 (1-15) years. The mean consumption dose was 2.05±1.8 (0.5-8) grams per day. Ten (56%) patients reported withdrawal seizure exacerbation when they stopped the marijuana. Only two patients (11%) reported side effects, and all patients found medicinal marijuana very helpful for seizure control and improvement of mood disorder.Conclusions:PWEs using medicinal marijuana have a common profile. They are usually young single men with drug-resistant epilepsy and psychiatric comorbidity. Most used marijuana before formal prescription and all believe the drug was effective on their seizure control. Because of the concurrent use of other antiseizure medications, it is complex to estimate the actual effect of marijuana.

scholarly journals Effectiveness, safety and assessing the results of drug therapy in patients with epilepsy

2021 ◽  
Vol 13 (3) ◽  
pp. 306-310
Author(s):  
Article Editorial
Keyword(s):  
Quality Of Life ◽  
Drug Therapy ◽  
Antiepileptic Drugs ◽  
Psychiatric Comorbidity ◽  
Foreign Experience ◽  
History Of ◽  
Patients With Epilepsy

On June 26, 2021, a meeting of the experts of the Russian League Against Epilepsy (RLAE) was held, dedicated to the effectiveness, safety and assessing the results of drug therapy in patients with epilepsy. Having considered the history of the issue and guided by domestic and foreign experience, the participants discussed the problems associated with the use of various antiepileptic drugs for different forms of epilepsy in patients of different sex and age. Special attention was paid to psychiatric comorbidity in patients with epilepsy, increasing their compliance with treatment and quality of life. The article presents the Resolution of RLAE experts meeting adopted as a result of the discussion.

scholarly journals Psychiatric Comorbidity and Quality of Life in patients with Epilepsy

2020 ◽  
Vol 5 (7) ◽  
pp. 1-5
Author(s):  
E.G. Amer ◽  
H.A. Elghaiaty ◽  
T.M. Khattab ◽  
Y.M. El-Tabakh
Keyword(s):  
Quality Of Life ◽  
Psychiatric Comorbidity ◽  
Patients With Epilepsy

Effects of fasting during Ramadan on seizure control and quality of life in patients with epilepsy

2020 ◽  
Vol 112 ◽  
pp. 107440
Author(s):  
Khalid Alqadi ◽  
Omar Alghamdi ◽  
Fawzi Babtain ◽  
Hanan Ba'arma ◽  
Somaya Bajammal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Seizure Control ◽  
Patients With Epilepsy

scholarly journals Executive dysfunction in idiopathic epilepsy: the journey so far

2020 ◽  
Vol 8 (9) ◽  
pp. 3409
Author(s):  
Haritha Koganti ◽  
Vimala Colaco ◽  
Harsha Sundaramurthy ◽  
Shasthara Paneyala ◽  
Nemichandra S. C.
Keyword(s):  
Neurological Disorders ◽  
Seizure Control ◽  
Disease Process ◽  
Executive Dysfunction ◽  
Idiopathic Epilepsy ◽  
Keywords Epilepsy ◽  
Therapeutic Implications ◽  
Contributory Factors ◽  
Patients With Epilepsy

Epilepsy is one of the most common neurological disorders known to man with a high global prevalence. This disease process affects the overall quality of life. In recent times the concept of executive dysfunction in patients with epilepsy has emerged. This phenomenon has widespread therapeutic implications. This review hence aims to summarize our current understanding of the topic, highlighting the results of benchmark studies and outlining the aspects that require further research. The keywords epilepsy, executive dysfunction and cognitive retraining were used in the search engines of Pubmed and Google scholar and articles identified were extensively reviewed. The consensus of this review is that executive dysfunction is a phenomenon that occurs in patients with epilepsy irrespective of epilepsy type, however the magnitude varies with contributory factors which include poor seizure control. Furthermore, patients with cognitive dysfunction have a further decline over the course of the disease process, however longitudinal studies in regard to the same are lacking and there is a need for additional research in this regard.

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