scholarly journals Glycemic Variation in Patients of Acute Coronary Syndrome with Hyperglycaemia and its Relationship with Oxidative Stress: A Pilot Study

2020 ◽  
Vol 07 (03) ◽  
pp. 16-19
Author(s):  
Kuldeep Kumar ◽  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Glycemic Variability ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Glycemic Status ◽  
Coronary Syndrome ◽  
The Relationship

Aim:The aim of this study was to establish the relationship between the glycemic variation in patients of Acute Coronary Syndrome (ACS) with hyperglycemia, oxidative stress and pre-discharge assessment of glycemic status by Oral Glucose Tolerance Test (OGTT). Materials and Method: Nineteen non-diabetic patients who presented with acute coronary syndrome with random blood sugar ≥200 mg/dl were recruited and glycemic variation was measured using CGMS followed by measurement of 8-isoprostanes PG-2alpha as a marker of oxidative stress, and pre-discharge OGTT was done to know the glycemic status at the time of discharge. Result: Mean MAGE (A parameter of glycemic variation) was 106.92±22.66 and mean 8-isoprostanes level was 206.05±179.57. There was no relationship between these two values. On doing OGTT, out of 19 non diabetic patients 11 turned out to be frank diabetic and 8 were having impaired glucose tolerance after OGTT, none were euglycemic. Conclusion:The study highlighted the issue of hyperglycaemia in ACS patients and their abnormal glucose tolerance in the short term, most of them turning to be frankly diabetic and being totally asymptomatic till the time of index event, although no correlation was found between glycemic variability and oxidative stress.

Oral Glucose Tolerance Test and Acute Coronary Syndrome

2010 ◽  
Vol 63 (3) ◽  
pp. 374-375
Author(s):  
Manuel F. Jiménez-Navarro ◽  
Jesús M. de la Hera-Galarza ◽  
Maria J. Molina-Mora ◽  
Ernesto Hernández-Martín
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Coronary Syndrome

scholarly journals Glycemic Status During Acute Coronary Syndrome of Non-Diabetic Patients

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 697-699
Author(s):  
Md Zillur Rahman ◽  
Nazmun Nahar ◽  
Md Azizul Hoque ◽  
Md Moksedur Rahman ◽  
Md Daharul Islam ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Fasting Blood Glucose ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Acute Hyperglycemia ◽  
Coronary Syndrome ◽  
Study Population ◽  
Glucose Abnormalities

The risk of diabetes mellitus and coronary heart disease is high among South-Asian population. In this study, our objective was to measure blood glucose level during acute coronary syndrome of previously known nondiabetic patients that will give the information about the frequency of acute hyperglycemia in acute coronary syndrome (ACS) among Bangladeshi population. It is an observational cross sectional study performed in Rajshahi Medical College Hospital (RMCH). A total of 248 non-diabetic subjects with ACS got admitted into hospital. Fasting blood glucose (FBS) and standard oral glucose tolerance test (OGTT ) within 3 days of ACS were done. This study was done to find out glucose abnormalities among ACS patients. Out of 248 study population, 135 (54.44%) had glucose abnormalities. Male was 87.10% (216). Among male, IGT (prediabetic) was 31.94% (69) and diabetic 24.54% (53). Mean age (±SD) of our study population was 51.71±11.84 years. Normal glucose tolerance (NGT) was found in 45.6% (113) cases, IGT (prediabetic) and diabetic were detected among 30.6% (76) and 23.8% (59) cases respectively. Non-diabetic Bangladeshi patients showed a high prevalence of hyperglycemia in acute coronary syndrome (ACS). We should create awareness about a new risk factor- acute hyperglycemia during acute coronary syndrome and take appropriate and effective measures to reduce morbidity as well as mortality as a consequence of acute hyperglycemia during ACS with or without diabetes.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 697-699

scholarly journals Oral glucose tolerance test predicts increased carotid plaque burden in patients with acute coronary syndrome

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183839 ◽  
Author(s):  
Thorarinn A. Bjarnason ◽  
Steinar O. Hafthorsson ◽  
Linda B. Kristinsdottir ◽  
Erna S. Oskarsdottir ◽  
Thor Aspelund ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Carotid Plaque ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Plaque Burden ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Coronary Syndrome

Detection of glucose metabolism disorders in coronary patients enrolled in cardiac rehabilitation: Is glycated haemoglobin useful? Data from the prospective REHABDIAB study

2018 ◽  
Vol 25 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Sopio Tatulashvili ◽  
Bénédicte Patois-Vergès ◽  
Amandine Nguyen ◽  
Marie-Cécile Blonde ◽  
Bruno Vergès
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Cardiac Rehabilitation ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Glycated Haemoglobin ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Coronary Syndrome

Introduction Diabetes and pre-diabetes are highly prevalent in patients with a history of acute coronary syndrome. This is why screening for glucose metabolism disorders is recommended in patients following an acute coronary syndrome. The aim of our study was to determine whether glycated haemoglobin alone compared with the oral glucose tolerance test could allow effective screening for glucose metabolism disorders in acute coronary syndrome patients undergoing cardiac rehabilitation. Patients and methods Among 347 patients with a recent history of acute coronary syndrome enrolled in our cardiac rehabilitation centre, 267 patients without previously known diabetes were recruited for this prospective study with performance of both oral glucose tolerance test and glycated haemoglobin measurement. The patients were divided into three groups: newly diagnosed diabetes mellitus, pre-diabetes and normoglycaemia according to the oral glucose tolerance test and glycated haemoglobin results. The results obtained with glycated haemoglobin were compared with those obtained with the oral glucose tolerance test, considered as the reference. Results For the diagnosis of diabetes, glycated haemoglobin had a sensitivity of 72% and a specificity of 100%. Positive and negative predictive values were high at 100% and 96%, respectively. However, for the diagnosis of pre-diabetes the sensitivity of glycated haemoglobin was low at 64% as were the specificity (53%) and the positive predictive values (37%). Glycated haemoglobin overdiagnosed pre-diabetes (52% vs 30%, p < 0.0001). For the diagnosis of normoglycaemia, the sensitivity of glycated haemoglobin was also low (48%). Conclusion According to our study, glycated haemoglobin has low sensitivity and specificity for the detection of pre-diabetes in patients with coronary disease enrolled in cardiac rehabilitation, and glycated haemoglobin over-diagnoses pre-diabetes in comparison with the oral glucose tolerance test.

scholarly journals 16 Impaired glucose tolerance and cardiovascular outcomes after an acute coronary syndrome—the important role of 1-h plasma glucose at the oral glucose tolerance test

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Viola Zywicki ◽  
Paola Capozza ◽  
Paolo Caravelli ◽  
Raffaele De Caterina
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Coronary Syndrome ◽  
Group A ◽  
Group B ◽  
Group D

Abstract Aims 2-h plasma glucose (PG) ≥140 mg/dl but &lt;200 mg/dl at the oral glucose tolerance test (OGT), defined as impaired glucose tolerance (IGT), has been reported as related to adverse cardiovascular outcomes in non-diabetic patients. The added value of 1-h plasma glucose (PG) ≥155 mg/dl at the OGTT is unknown. We investigated the value of 1-h PG in IGT patients admitted for an acute coronary syndrome (ACS) in relation to in hospital outcome. Methods and results Among 109 patients admitted to Coronary Care Unit for an ACS, with both no previous diagnosis of diabetes and first-line in-hospital screening with glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) negative for either diabetes and prediabetes, OGTT was performed. On the basis of the OGTT results, 21 patients (19.3%) were newly diagnosed diabetes. The remaining 88 patients were divided into: Group A: ‘fully glucose tolerant’, with 1 h PG-OGTT &lt;155 mg/dl and 2 h PG-OGTT &lt;140 mg/dl; Group B: ‘early-impaired IGT’ with 1 h-PG at OGTT ≥155 mg/dl and 2 h-PG &lt;140 mg/dl; Group C: ‘late impaired-IGT’, with 1 h-PG at OGTT &lt;155 mg/dl and 2 h PG-OGTT ≥140 mg/dl; and Group D: ‘fully impaired IGT’, with 1 h-PG at OGTT ≥155 mg/dl and 2 h PG-OGTT ≥140 mg/dl. In this analysis we compared the four groups as to cardiac markers and days of hospitalization by the Kruskal–Wallis test and correcting multiple comparisons with the Bonferroni’s adjustment. On the basis of the OGTT results, 12 patients (13.5%) belonged to Group A, 32 (39%) to Group B, 8 (9%) to Group C, and 35 (39%) patients to Group D. Group D patients had significant higher Hs-TnT at admission compared to Group A (P = 0.013), Group B (P = 0.023), and Group C (P = 0.005). Group D patients featured significant higher Hs-TnT peak compared to Group A (P = 0.016) and Group B (P = 0.005). Patients in Group D had a longer hospitalization compared to Group A (P = 0.005). Conclusions In the setting of ACS, compared to non-diabetic patients with a normal OGTT, only IGT patients characterized by both 1 h-PG ≥155 mg/dl and 2 h PG ≥ 140 mg/dl had more severe myocardial injury and longer hospitalization. These results suggest that, within currently defined IGT patients, 1 h-PG importantly contributes to assessing cardiac risk.

scholarly journals TNFα Mediates the Interaction of Telomeres and Mitochondria Induced by Hyperglycemia: A Rural Community-Based Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Lu Lyu ◽  
Shuli He ◽  
Huabing Zhang ◽  
Wei Li ◽  
Jingbo Zeng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glucose Tolerance ◽  
Rural Community ◽  
Rural China ◽  
Inflammatory Factors ◽  
Oral Glucose ◽  
Sod Activity ◽  
Cross Sectional ◽  
Mitochondrial Dna Copy Number ◽  
The Relationship

This study is aimed at evaluating the relationship between leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) in a noninterventional rural community of China with different glucose tolerance statuses. In addition, we investigate whether the indicators of oxidative stress and inflammation were involved and identify mediators among them. A total of 450 subjects in rural China were included and divided into two groups according to a 75 g oral glucose tolerance test (OGTT): the abnormal glucose metabolism (AGM, n=257, 57.1%) group and the normal glucose tolerance (NGT, n=193, 42.9%) group. Indicators of oxidative stress (superoxide dismutase (SOD) and glutathione reductase (GR)) and inflammatory indices (tumor necrosis factor α (TNFα) and interleukin-6 (IL-6)) were all determined by ELISA. LTL and mtDNAcn were measured using a real-time PCR assay. Linear regressions were used to adjust for covariates that might affect the relationship between LTL and mtDNAcn. Mediation analyses were utilized to evaluate the mediators. In the AGM, LTL was correlated with mtDNAcn (r=0.214, p=0.001), but no correlation was found in the NGT. The association between LTL and mtDNAcn was weakened after adjusting for inflammatory factors in the AGM (p=0.087). LTL and mtDNAcn were both inversely related to HbA1c, IL-6, TNFα, and SOD activity. Mediation analysis demonstrated that TNFα was a significant mediator in the telomere-mitochondrial interactome in the AGM. This result suggests that inflammation and oxidative stress may play a vital role in telomere shortening as well as mitochondrial dysfunction. In the subjects with hyperglycemia, a significant positive correlation is observed between LTL and mtDNAcn, which is probably mediated by TNFα. TNFα may be considered a potential therapeutic target against aging-related disease in hyperglycemia.

scholarly journals Association of Isoprostanes-Related Oxidative Stress with Vulnerability of Culprit Lesions in Diabetic Patients with Acute Coronary Syndrome

2019 ◽  
Vol 60 (2) ◽  
pp. 271-279 ◽  
Author(s):  
Gong Su ◽  
Tao Zhang ◽  
Hong-Xia Yang ◽  
Wen-Long Dai ◽  
Tao Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Diabetic Patients ◽  
Coronary Syndrome
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