scholarly journals Zika Virus: An Emerging Mosquito-Borne Disease Threat in Kerala

2021 ◽  
Vol 53 (03) ◽  
pp. 201-212
Author(s):  
MS Sasi ◽  
Keyword(s):  
Vector Control ◽  
Zika Virus ◽  
Critical Level ◽  
Preliminary Investigation ◽  
Scale Up ◽  
Local Health ◽  
Age Group ◽  
Entomological Surveillance ◽  
Aedes Mosquitoes ◽  
Health Institutions

First laboratory confirmed Zika case in Kerala was reported in Thiruvananthapuram, on 8th July 2021. Since then, 68 ZIKV positive cases have been reported from Kerala, with majority of cases from Thiruvananthapuram Corporation area. Based on the preliminary investigation, micro containment zones were identified and detailed investigation was carried out in these areas. Entomological surveillance indicated that all the three species of Aedes mosquitoes - Ae. aegypti, Ae. albopictus and Ae. vittatus were present in the survey areas. The Aedes larval indices were found above the critical level. The most preferred habitats of Aedes mosquitoes were water stagnated areas in cemented floor of the newly constructing buildings followed by cement tanks/cement pits and discarded tires. ZIKV could be detected from all the three Aedes mosquitoes collected from the micro containment zones. Trasovarial transmission of ZIKV could be noted in this outbreak. Vector control was intensified with the active participation of local bodies and local health institutions. The epidemiological study showed most of the Zika positive cases has fever, rash and conjunctivitis and in majority of cases, the duration of the illness lasts only for 2-3 days. The females were more affected. The most affected age group was 21-30 followed by 31-40. Among the 68 ZIKV positive cases, 7 (10.29%) were pregnant women. No major anomaly was detected in ZIKV positive cases; however there is a need to scale up surveillance and vector control activities to prevent further outbreaks in Kerala and elsewhere.

scholarly journals Control of Aedes aegypti in a remote Guatemalan community vulnerable to dengue, chikungunya and Zika virus: Prospective evaluation of an integrated intervention of web-based health worker training in vector control, low-cost ecological ovillantas, and community engagement

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 598
Author(s):  
Gerard Ulibarri ◽  
Angel Betanzos ◽  
Mireya Betanzos ◽  
Juan Jacobo Rojas
Keyword(s):  
Community Engagement ◽  
Vector Control ◽  
Zika Virus ◽  
Health Personnel ◽  
Mosquito Control ◽  
Health Workers ◽  
Low Cost ◽  
Local Health ◽  
Worker Training ◽  
Integrated Intervention

Objective: To study the effectiveness of an integrated intervention of health worker training, a low-cost ecological mosquito ovitrap, and community engagement on Aedes spp. mosquito control over 10 months in 2015 in an urban remote community in Guatemala at risk of dengue, chikungunya and Zika virus transmission. Methods: We implemented a three-component integrated intervention consisting of: web-based training of local health personnel in vector control, cluster-randomized assignment of ecological ovillantas or standard ovitraps to capture Aedes aegypti mosquito eggs, and community engagement to promote participation of community members and health personnel in the understanding and maintenance of ovitraps for mosquito control. The intervention was implemented in local collaboration with the Ministry of Health’s Vector Control Programme, and in international collaboration with the National Institute of Public Health in Mexico. Findings: Eighty percent of the 25 local health personnel enrolled in the training programme received accreditation of their improved knowledge of vector control. Significantly more eggs were trapped by  ecological ovillantas than standard ovitraps over the 10 month (42 week) study period (t=5.2577; p<0.05). Among both community members and health workers, the levels of knowledge, interest, and participation in community mosquito control and trapping increased. Recommendations for enhancing and sustaining community mosquito control were identified. Conclusion: Our three-component integrated intervention proved beneficial to this remote community at risk of mosquito-borne diseases such as dengue, chikungunya, and Zika. The combination of training of health workers, low-cost ecological ovillanta to destroy the second generation of mosquitoes, and community engagement ensured the project met local needs and fostered collaboration and participation of the community, which can help improve sustainability. The ovillanta intervention and methodology may be modified to target other species such as Culex, should it be established that such mosquitoes carry Zika virus in addition to Aedes.

scholarly journals Preliminary results on the control of Aedes spp. in a remote Guatemalan community vulnerable to dengue, chikungunya and Zika virus: community participation and use of low-cost ecological ovillantas for mosquito control

F1000Research ◽  
2017 ◽  
Vol 5 ◽  
pp. 598 ◽  
Author(s):  
Gerard Ulibarri ◽  
Angel Betanzos ◽  
Mireya Betanzos ◽  
Juan Jacobo Rojas
Keyword(s):  
Community Engagement ◽  
Vector Control ◽  
Zika Virus ◽  
Health Personnel ◽  
Mosquito Control ◽  
Health Workers ◽  
Low Cost ◽  
Local Health ◽  
Community Members ◽  
Integrated Intervention

Objective: To study the effectiveness of an integrated intervention of health worker training, a low-cost ecological mosquito ovitrap, and community engagement on Aedes spp. mosquito control over 10 months in 2015 in an urban remote community in Guatemala at risk of dengue, chikungunya and Zika virus transmission. Methods: We implemented a three-component integrated intervention consisting of: web-based training of local health personnel in vector control, cluster-randomized assignment of an ecological modified ovitrap (ovillantas: ovi=egg, llanta=tire) or standard ovitraps to capture Aedes spp. mosquito eggs (no efforts have been taken to determine the exact Aedes species at this moment), and community engagement to promote participation of community members and health personnel in the understanding and maintenance of ovitraps for mosquito control. The intervention was implemented in local collaboration with Guatemala’s  Ministry of Health’s Vector Control Programme, and in international collaboration with the National Institute of Public Health in Mexico. Findings: Eighty percent of the 25 local health personnel enrolled in the training programme received accreditation of their improved knowledge of vector control. When ovillantas were used in a cluster of ovitraps (several in proximity), significantly more eggs were trapped by  ecological ovillantas than standard ovitraps over the 10 month (42 week) study period (t=5.2577; p<0.05). Repetitive filtering and recycling of the attractant solution (or water) kept the ovillanta clean, free from algae growth. Among both community members and health workers, the levels of knowledge, interest, and participation in community mosquito control and trapping increased. Recommendations for enhancing and sustaining community mosquito control were identified. Conclusion: Our three-component integrated intervention proved beneficial to this remote community at risk of mosquito-borne diseases such as dengue, chikungunya, and Zika. The combination of training of health workers, cluster use of low-cost ecological ovillanta to destroy the second generation of mosquitoes, and community engagement ensured the project met local needs and fostered collaboration and participation of the community, which can help improve sustainability. The ovillanta intervention and methodology may be modified to target other species such as Culex, should it be established that such mosquitoes carry Zika virus in addition to Aedes.

scholarly journals Preliminary results on the control of Aedes spp. in a remote Guatemalan community vulnerable to dengue, chikungunya and Zika virus: community participation and use of low-cost ecological ovillantas for mosquito control

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 598 ◽  
Author(s):  
Gerard Ulibarri ◽  
Angel Betanzos ◽  
Mireya Betanzos ◽  
Juan Jacobo Rojas
Keyword(s):  
Community Engagement ◽  
Vector Control ◽  
Zika Virus ◽  
Health Personnel ◽  
Mosquito Control ◽  
Health Workers ◽  
Low Cost ◽  
Local Health ◽  
Community Members ◽  
Integrated Intervention

Objective: To study the effectiveness of an integrated intervention of health worker training, a low-cost ecological mosquito ovitrap, and community engagement on Aedes spp. mosquito control over 10 months in 2015 in an urban remote community in Guatemala at risk of dengue, chikungunya and Zika virus transmission. Methods: We implemented a three-component integrated intervention consisting of: web-based training of local health personnel in vector control, cluster-randomized assignment of an ecological modified ovitrap (ovillantas: ovi=egg, llanta=tire) or standard ovitraps to capture Aedes spp. mosquito eggs (no efforts have been taken to determine the exact Aedes species at this moment), and community engagement to promote participation of community members and health personnel in the understanding and maintenance of ovitraps for mosquito control. The intervention was implemented in local collaboration with Guatemala’s  Ministry of Health’s Vector Control Programme, and in international collaboration with the National Institute of Public Health in Mexico. Findings: Eighty percent of the 25 local health personnel enrolled in the training programme received accreditation of their improved knowledge of vector control. When ovillantas were used in a cluster of ovitraps (several in proximity), significantly more eggs were trapped by  ecological ovillantas than standard ovitraps over the 10 month (42 week) study period (t=5.2577; p<0.05). Repetitive filtering and recycling of the attractant solution (or water) kept the ovillanta clean, free from algae growth. Among both community members and health workers, the levels of knowledge, interest, and participation in community mosquito control and trapping increased. Recommendations for enhancing and sustaining community mosquito control were identified. Conclusion: Our three-component integrated intervention proved beneficial to this remote community at risk of mosquito-borne diseases such as dengue, chikungunya, and Zika. The combination of training of health workers, cluster use of low-cost ecological ovillanta to destroy the second generation of mosquitoes, and community engagement ensured the project met local needs and fostered collaboration and participation of the community, which can help improve sustainability. The ovillanta intervention and methodology may be modified to target other species such as Culex, should it be established that such mosquitoes carry Zika virus in addition to Aedes.

scholarly journals Challenging the status quo: results of an acceptability and feasibility study of hypertensive disorders of pregnancy (HDP) management pathways in Indonesian primary care

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fitriana Murriya Ekawati ◽  
Ova Emilia ◽  
Jane Gunn ◽  
Sharon Licqurish ◽  
Phyllis Lau
Keyword(s):  
Primary Care ◽  
Health Care Professionals ◽  
Primary Care Practice ◽  
Scale Up ◽  
Primary Care Providers ◽  
Care Practice ◽  
Local Health ◽  
Care Providers ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

Abstract Background Hypertensive disorders of pregnancy (HDP) are the leading cause of maternal mortality in Indonesia. Focused HDP management pathways for Indonesian primary care practice have been developed from a consensus development process. However, the acceptability and feasibility of the pathways in practice have not been explored. This study reports on the implementation process of the pathways to determine their acceptability and feasibility in Indonesian practice. Methods The pathways were implemented in three public primary care clinics (Puskesmas) in Yogyakarta province for a month, guided by implementation science frameworks of Medical Research Council (MRC) and the Practical Robust Implementation and Sustainability Model (PRISM). The participating providers (general practitioners (GPs), midwives, and nurses) were asked to use recommendations in the pathways for a month. The pathway implementation evaluations were then conducted using clinical audits and a triangulation of observations, focus groups (FGs), and interviews with all of the participants. Clinical audit data were analysed descriptively, and qualitative data were analysed using a mix of the inductive-deductive approach of thematic analysis. Results A total of 50 primary care providers, four obstetricians, a maternal division officer in the local health office and 61 patients agreed to participate, and 48 of the recruited participants participated in evaluation FGs or interviews. All of the providers in the Puskesmas attempted to apply recommendations from the pathways to various degrees, mainly adopting preeclampsia risk factor screenings and HDP monitoring. The participants expressed that the recommendations empowered their practice when it came to HDP management. However, their practices were challenged by professional boundaries and hierarchical barriers among health care professionals, limited clinical resources, and regulations from the local health office. Suggestions for future scale-up studies were also mentioned, such as involving champion obstetricians and providing more patient education toolkits. Conclusion The HDP management pathways are acceptable and feasible in Indonesian primary care. A further scale-up study is desired and can be initiated with investigations to minimise the implementation challenges and enhance the pathways’ value in primary care practice.

scholarly journals Rosuvastatin cocrystals: an attempt to modulate physicochemical parameters

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Venkata Deepthi Vemuri ◽  
Srinivas Lankalapalli
Keyword(s):  
Physicochemical Properties ◽  
Dissolution Rate ◽  
Functional Groups ◽  
Preliminary Investigation ◽  
Scale Up ◽  
Solvent Evaporation ◽  
Molar Ratio ◽  
The Novel ◽  
Formulation Development ◽  
Hydrogen Bond Interaction

Abstract Background The meager physicochemical properties like low solubility and low dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development. In the present work, we explore the evolution of rosuvastatin cocrystal, which may offer the synergetic physico-chemical properties of the drug. Cocrystal crafting depends on two possible intermolecular interactions; heteromeric and the homomeric selection of compounds with complementary functional groups are contemplated as a possible cause of supramolecular synthons in cocrystal formation. Specifically, cocrystals of rosuvastatin with l-asparagine and l-glutamine with molar ratio (1:1) were fabricated by using slow solvent evaporation and slow evaporation techniques. Novel cocrystals of rosuvastatin-asparagine (RSC-C) and rosuvastatin-glutamine (RSC-G) cocrystals obtained by slow solvent evaporation were utilized for preliminary investigation and further scale-up was done by using the solvent evaporation technique. Results The novel cocrystals showed a new characteristic of powder X-ray diffraction, thermograms of differential scanning calorimetry, 1H liquid FT-NMR spectra, and scanning electron microscopy. These results signify the establishment of intermolecular interaction within the cocrystals. In both the novel cocrystals, rosuvastatin was determined to be engaged in the hydrogen bond interaction with the complementary functional groups of l-asparagine and l-glutamine. Compared with the pure rosuvastatin, RSC-C and RSC-G cocrystal showed 2.17-fold and 1.60-fold improved solubility respectively. The dissolution test showed that the RSC-C and RSC-G cocrystal exhibited 1.97-fold and 1.94-fold higher dissolution rate than the pure rosuvastatin in pH6.8 phosphate buffer respectively. Conclusion Modulation in the chemical environment, improvement in the solubility, and dissolution rate demonstrated the benefit of co-crystallization to improve the physicochemical properties of the drug. Graphical abstract

A Retrospective Descriptive Study on Death Due to Cyanide Poisoning Over a Period of 20 Years in Government Medical College, Thiruvananthapuram

2021 ◽  
Vol 8 (30) ◽  
pp. 2697-2701
Author(s):  
Sasikala K ◽  
Vitni Fernz ◽  
Abitha Raj B.T ◽  
Ajith V. Asok ◽  
Amritha Mathew ◽  
...  
Keyword(s):  
Social Sciences ◽  
Preliminary Investigation ◽  
Laboratory Data ◽  
Descriptive Study ◽  
Serial Killers ◽  
Age Group ◽  
Cyanide Poisoning ◽  
Microsoft Excel ◽  
Medical College ◽  
Pro Forma

BACKGROUND Cyanide is a rapidly acting poison which has been the suicidal agent of choice since time unknown. Its notoriety also extends to homicide, and it has often been used by serial killers. It is found in nature and is used in various industries, but is difficult to obtain nowadays as a result of strict policy implementation. METHODS All cases of cyanide poisoning over a period of 20 years from 2000 to 2019 were studied. Samples were sent for identification and quantification by GC-MS to the chemical examiner’s laboratory. Data was collected in pro forma and entered into Microsoft Excel and analysed using statistical package for social sciences (SPSS). RESULTS A total of 84 cases were studied over a period of 20 years. The majority of cases were recorded in the first decade of the study period. Most common age group involved was 31 to 40 years. Males comprised 84.9 % of the total. Majority were suicidal in nature, and 22.6 % were suicide pacts. The reason for committing suicide could not be found in 59.3 %. 67.9 % were found dead or brought dead to the hospital. In 24 % cases, the typical smell of bitter almonds was identified. Police were able to make out the presence of poison in 83.3 % during the preliminary investigation. CONCLUSIONS Males were the commonly affected. Ingestion of poison was the method of administration in all cases. Majority were suicides, and occurred in the residence of the victims. In majority of cases, police could identify the cause of death as poisoning. The characteristic smell could be identified only in a few cases. KEYWORDS Cyanide, Corrosion, Poisoning, Suicide

scholarly journals Modeling and Preparedness: The Transmission Dynamics of COVID-19 Outbreak in Provinces of Ecuador

2020 ◽  
Author(s):  
Carlos Enrique Bustamante Orellana ◽  
Jordy Jose Cevallos Chavez ◽  
Cesar Montalvo ◽  
Jeff Sullivan ◽  
Edwin Michael ◽  
...  
Keyword(s):  
Population Density ◽  
Disease Burden ◽  
Critical Level ◽  
Local Health ◽  
Isolation Rate ◽  
Preparedness Planning ◽  
Local Health Care ◽  
Local Health Care System ◽  
Current Outbreak ◽  
The City

Coronavirus disease 2019 (COVID-19), a novel infectious disease first identified in December 2019 in the city of Wuhan of China, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease has become a pandemic in just a few months and spread globally with more than 2.89 million cases and 203,000 deaths across 185 countries, as of April 26th, 2020. Ecuador has reported one of the highest rates of COVID-19 in Latin America, with more than 10K cases and 500 deaths in a country of approximately 17 million people. The dynamics of the outbreak is being observed quite different in different provinces of Ecuador with high reported prevalence in some low population density provinces. In this study, we aim to understand variations in outbreaks between provinces and provide assistance in essential preparedness planning in order to respond effectively to ongoing COVID-19 outbreak. The study estimated the critical level of quarantine rate along with corresponding leakage in order to avoid overwhelming the local health care system. The results suggest that provinces with high population density can avoid a large disease burden provided they initiate early and stricter quarantine measures even under low isolation rate. To best of our knowledge, this study is first from the region to determine which provinces will need much preparation for current outbreak in fall and which might need more help.

scholarly journals Entomological Surveillance for Zika and Dengue Virus in Aedes Mosquitoes: Implications for Vector Control in Thailand

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 442
Author(s):  
Nathamon Kosoltanapiwat ◽  
Jarinee Tongshoob ◽  
Preeraya Singkhaimuk ◽  
Chanyapat Nitatsukprasert ◽  
Silas A. Davidson ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Vector Control ◽  
Mosquito Control ◽  
Case Reports ◽  
Dengue Case ◽  
Prevention Measures ◽  
Entomological Surveillance ◽  
Vector Borne Diseases ◽  
Envelope Sequence ◽  
Surveillance Programs

Entomological surveillance for arthropod-borne viruses is vital for monitoring vector-borne diseases and informing vector control programs. In this study, we conducted entomological surveillance in Zika virus endemic areas. In Thailand, it is standard protocol to perform mosquito control within 24 h of a reported dengue case. Aedes females were collected within 72 h of case reports from villages with recent Zika–human cases in Kamphaeng Phet Province, Thailand in 2017 and 2018. Mosquitoes were bisected into head-thorax and abdomen and then screened for Zika (ZIKV) and dengue (DENV) viruses using real-time RT-PCR. ZIKV RNA was detected in three samples from two female Ae. aegypti (1.4%). A partial envelope sequence analysis revealed that the ZIKV sequences were the Asian lineage identical to sequences from ZIKV-infected cases reported in Thailand during 2016 and 2017. Dengue virus-1 (DENV-1) and dengue virus-4 (DENV-4) were found in four Ae. aegypti females (2.8%), and partial capsid sequences were nearly identical with DENV-1 and DENV-4 from Thai human cases reported in 2017. Findings in the current study demonstrate the importance of entomological surveillance programs to public health mosquito-borne disease prevention measures and control.

scholarly journals National malaria vector control policy: an analysis of the decision to scale-up larviciding in Nigeria

2015 ◽  
Vol 31 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Kemi Tesfazghi ◽  
Jenny Hill ◽  
Caroline Jones ◽  
Hilary Ranson ◽  
Eve Worrall
Keyword(s):  
Vector Control ◽  
Malaria Vector ◽  
Scale Up ◽  
Control Policy ◽  
Malaria Vector Control
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