Cure Fraction Model for the Estimation of Long-term Survivors of HIV/AIDS Patients under Antiretroviral Therapy

2018 ◽  
Vol 50 (03) ◽  
pp. 1-10
Author(s):  
Arpan Kumar Thakur ◽  
Keyword(s):  
Antiretroviral Therapy ◽  
Aids Patients ◽  
Cure Fraction ◽  
Long Term Survivors ◽  
Hiv Aids

scholarly journals Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in southwestern China: a cohort study

2020 ◽  
Author(s):  
Yunxuan Huang ◽  
Oulu Zhou ◽  
Zhigang Zheng ◽  
Yuexiang Xu ◽  
Yi Shao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Mortality Risk ◽  
Hiv Positive ◽  
Aids Patients ◽  
Death Risk ◽  
Long Term Mortality ◽  
Hiv Aids

Abstract Objective To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study was performed in southwestern China. Methods The cohort was established based on HIV/AIDS patients on ART recruited in Guigang city, Guangxi, China, from January 2004 to December 2018. Participants were divided into ADE and non-ADE groups, and were followed-up every six months to observe treatment outcomes. Comparison of mortality between groups was performed using the log-rank test and Kaplan-Meier analysis. Cox proportional hazard regression was used to explore the risk factors of mortality. 1:1 propensity score matching (PSM) was used to balance confounding factors and adjust the mortality risk. Results Of 6,757 participants with 29,096.06 person-years of follow-up, 16.86% (1,139/6,757) belonged to ADE group while the others (83.14%) belonged to the non-ADE group. The most common cause of death by ADE was disseminated mycosis (31.65%), followed by recurrent severe bacterial pneumonia (28.48%), herpes zoster(17.72%), and extra-pulmonary tuberculosis (8.86%). The mortality of the ADE group was significantly higher than that of the non-ADE group [3.45/100 person-years (95% CI: 2.92-3.97) vs. 2.34/100 person-years (95%CI: 2.15-2.52), P<0.001]. The death risk of the ADE group was also higher than that of the non- ADE group [adjusted hazard ratio (aHR) =1.291, 95% CI: 1.061-1.571, P =0.011], which was confirmed by PSM analysis (aHR=1.581, 95% CI: 1.192-2.099, P =0.002). Cox analysis indicated that ADE, older age, male gender, previous non-use of cotrimoxazole, advanced WHO clinical stage, and low baseline CD4+ cell count were the risk factors for death. Conclusions Even on ART, the mortality risk of HIV positive individuals with ADE was higher than those without ADE. Active testing, earlier diagnosis, and timely therapy with ART may reduce the death risk of ADE.

Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy

2021 ◽  
Vol 147 ◽  
pp. 111269
Author(s):  
Gordana Dragović ◽  
Mladen Andjić ◽  
Boško Toljić ◽  
Djordje Jevtović ◽  
Relja Lukić ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
Telomere Length ◽  
Aids Patients ◽  
Relative Telomere Length ◽  
Combined Antiretroviral Therapy ◽  
Hiv Aids

scholarly journals Polymorphisms and Mutational Covariation Associated with Death in a Prospective Cohort of HIV/AIDS Patients Receiving Long-Term ART in China

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170139 ◽  
Author(s):  
Pengtao Liu ◽  
Yi Feng ◽  
Jianjun Wu ◽  
Suian Tian ◽  
Bin Su ◽  
...  
Keyword(s):  
Prospective Cohort ◽  
Aids Patients ◽  
Hiv Aids

scholarly journals Adherence to antiretroviral therapy among HIV/AIDS patients in the context of early treatment initiation in Vietnam

2018 ◽  
Vol Volume 12 ◽  
pp. 2131-2137 ◽  
Author(s):  
Hue Thi Mai ◽  
Le Minh Giang ◽  
Bach Xuan Tran ◽  
Ha Do ◽  
Carl Latkin ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Early Treatment ◽  
Treatment Initiation ◽  
Aids Patients ◽  
Hiv Aids
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