scholarly journals The relationship between the nitric oxide synthase gene and the risk of hypertension defi ned according to ambulatory blood pressures

SA Heart ◽  
2017 ◽  
Author(s):  
Geoffrey Candy ◽  
Danelle Badenhorst ◽  
Elena Libhaber ◽  
Pinhas Sareli ◽  
Gavin R. Norton ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Pressures ◽  
Oxide Synthase ◽  
Ambulatory Blood Pressures ◽  
The Relationship

The Relationship Between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele

2016 ◽  
Vol 20 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Cigdem Yuce Kahraman ◽  
Sener Tasdemir ◽  
Ibrahim Sahin ◽  
Ebru Marzioglu Ozdemir ◽  
Oguzhan Yaralı ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
The Relationship

Nitric oxide in exhaled gas and tetrahydrobiopterin in plasma after exposure to hyperoxia

2020 ◽  
Vol 47 (1) ◽  
pp. 197-202
Author(s):  
Ronja Hesthammer ◽  
◽  
Stian Dahle ◽  
Jon Peder Storesund ◽  
Torunn Eide ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Healthy Subjects ◽  
Blood Samples ◽  
Time Points ◽  
Hyperoxic Exposure ◽  
Oxide Synthase ◽  
The Relationship

The fraction of nitric oxide in exhaled gas (FENO) is decreased after exposure to hyperoxia in vivo, although the mechanisms for this decrease is not clear. A key co-factor for nitric oxide synthase (NOS), tetrahydrobiopterin (BH4), has been shown to be oxidized in vitro when exposed to hyperoxia. We hypothesized that the decrease of FENO is due to decreased enzymatic generation of NO due to oxidation of BH4. The present study was performed to investigate the relationship between levels of FENO and plasma BH4 following hyperoxic exposure in humans. Two groups of healthy subjects were exposed to 100% oxygen for 90 minutes. FENO was measured before and 10 minutes (n = 13) or 60 minutes (n = 14) after the exposure. Blood samples were collected at the same time points for quantification of biopterin levels (BH4, BH2 and B) using LC-MS/MS. Each subject was his or her own control, breathing air for 90 minutes on a separate day. Hyperoxia resulted in a 28.6 % decrease in FENO 10 minutes after exposure (p < 0.001), confirming previous findings. Moreover, hyperoxia also caused a 14.2% decrease in plasma BH4 (p = 0.012). No significant differences were observed in the group measured 60 minutes after exposure. No significant correlation was found between the changes in FENO and BH4 after the hyperoxic exposure (r = 0.052, p = 0.795), this might be due to the recovery of BH4 being faster than the recovery of FENO.

scholarly journals Regulation of iNOS on Immune Cells and Its Role in Diseases

2018 ◽  
Vol 19 (12) ◽  
pp. 3805 ◽  
Author(s):  
Qingjie Xue ◽  
Yingchun Yan ◽  
Ruihua Zhang ◽  
Huabao Xiong
Keyword(s):  
Nitric Oxide ◽  
T Cells ◽  
Nitric Oxide Synthase ◽  
Immune Cells ◽  
Laboratory Research ◽  
Experimental Animals ◽  
Using Data ◽  
Oxide Synthase ◽  
The Relationship ◽  
Inducible Nitric Oxide

In recent years, there have been many studies on the function of nitric oxide synthase (NOS) in experimental animals and humans. This review analyzes and explores the relationship between inducible nitric oxide synthase (iNOS) and T cells, macrophages, and dendritic cell et al. differentiation using data based on laboratory research, highlighting recent NOS laboratory research. Our insights into research prospects and directions are also presented.

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