scholarly journals ASSOCIATION BETWEEN SMOKING BEHAVIOUR AND GLYCOHEMOGLOBINE LEVELS AMONG ADULT JAVANESE INDONESIAN SMOKERS

2020 ◽  
Vol 17 (2) ◽  
pp. 76-85
Author(s):  
Christine Patramurti ◽  
Fenty Fenty
Keyword(s):  
Research Finding ◽  
Smoking Behaviour ◽  
Multiple Correlation Coefficient ◽  
Impaired Glucose Metabolism ◽  
Multiple Correlation ◽  
Β Cell ◽  
Smoking Duration ◽  
Whole Blood Sample ◽  
Hba1c Levels

Nicotine, the active compound in cigarettes, can cause impaired glucose metabolism by increasing insulin resistance as well as decreasing insulin secretion in β cell pancreas. This condition can increase the risk of type 2 diabetes in human. This study aims to evaluate the effect of smoking behaviour, determined by Cigarette per Day (CPD) and smoking duration, on glychohemoglobine (HbA1c) levels of Javanese Indonesian smokers. 30 smokers were studied consisting of 7 smokers with <10 CPD, 19 smokers with 11-20 CPD and 4 smokers with 21-30 CPD. They had been smoking for more than 10 years. The whole blood sample was used to examine the HbA1c levels. The HbA1c levels were tested at Bethesda Hospital's clinic laboratories using Architect 600 instrument. The results showed that CPD and smoking duration significantly influenced HbA1c, in which F count was > F table (370.541> 3.354) with significance < 0.05 (2.35. 10-20 < 0.05) and multiple correlation coefficient (R) of 0.982. Therefore, based on this research finding, it was concluded that longer smoking duration and higher CPD caused higher smokers’ HbA1c level.

scholarly journals Therapeutic efficacy and safety of initial triple combination of metformin, sitagliptin, and lobeglitazone in drug-naïve patients with type 2 diabetes: initial triple study

2020 ◽  
Vol 8 (1) ◽  
pp. e000807
Author(s):  
Soo Lim ◽  
Eu Jeong Ku ◽  
Seo Young Lee ◽  
Ji Hyun Lee ◽  
Jie-Eun Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Function ◽  
Therapy Group ◽  
Efficacy And Safety ◽  
Β Cell ◽  
Β Cell Function ◽  
Conventional Therapy Group ◽  
Drug Naïve ◽  
Hba1c Levels

ObjectiveTo compare the efficacy and safety of an initial triple therapy using metformin, a dipeptidyl peptidase-4 (DPP4) inhibitor, and thiazolidinedione with a stepwise approach using sulfonylurea and metformin in new-onset, drug-naïve patients with type 2 diabetes.Research design and methodsAmong drug-naïve patients with 9.0%–12.0% glycated hemoglobin (HbA1c) but no hyperglycemic symptoms, 100 subjects who started triple medications (metformin 1000 mg/day, sitagliptin 100 mg/day, and lobeglitazone 0.5 mg/day) were selected as an initial triple therapy group. Age and body mass index-matched subjects (n=100) who started glimepiride (≥2 mg/day with uptitration) and metformin (≥1000 mg/day with uptitration) were selected as a conventional therapy group. We investigated changes in HbA1c level, dynamic indexes for insulin sensitivity and β-cell function, and hypoglycemia.ResultsAfter 12 months of treatment, HbA1c levels decreased significantly in both groups: from 10.7%±1.0% to 6.7%±1.3% in the triple group, and from 10.5%±1.0% to 7.3%±1.2% in the conventional therapy group. At 12 months, achievement of the HbA1c target (<7.0%) was higher in the triple group than in the conventional group (70% vs 52%, p<0.01). Dynamic indexes related to β-cell function and insulin sensitivity improved, and albuminuria reduced significantly only in the triple group. Hypoglycemia was more common in the conventional group.ConclusionsInitial triple combination therapy with the DPP4 inhibitor, metformin, and thiazolidinedione showed a higher achievement of the target HbA1c goal with a lower risk of hypoglycemia, better restoration of β-cell function, and multiple metabolic benefits, implying durable glycemic control. This strategy may be useful for patients presenting with type 2 diabetes and high HbA1c levels.

High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men

2014 ◽  
Vol 46 (14) ◽  
pp. 497-504 ◽  
Author(s):  
Kumpei Tanisawa ◽  
Tomoko Ito ◽  
Xiaomin Sun ◽  
Ryuken Ise ◽  
Satomi Oshima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cell Function ◽  
Glycated Hemoglobin ◽  
Β Cell ◽  
Japanese Men ◽  
Polygenic Risk ◽  
Β Cell Function ◽  
Hba1c Levels

High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 diabetes mellitus (T2DM) and improved β-cell function; genetic factors also determine these risks. This cross-sectional study investigated whether CRF modifies the association of polygenic risk of T2DM with glucose metabolism in nondiabetic Japanese men. Fasting plasma glucose, insulin, and glycated hemoglobin (HbA1c) levels were measured in 174 Japanese men (age: 20–79 yr). β-Cell function and insulin resistance were evaluated by calculating HOMA-β and HOMA-IR, respectively. CRF was assessed by measuring maximal oxygen uptake (V̇o2max). Subjects were divided into the low and high CRF groups within each age group according to the median V̇o2max. Eleven single nucleotide polymorphisms (SNPs) associated with T2DM were analyzed and used to calculate genetic risk score (GRS); subjects were divided into the low, middle, and high GRS groups. The high GRS group had higher HbA1c levels than the low GRS group in both the low and high CRF groups ( P < 0.05). Furthermore, the individuals with a high GRS had a lower HOMA-β than those with a low GRS regardless of CRF ( P < 0.05). In multiple linear regression analysis, although GRS was a significant predictor of HbA1c ( β = 0.153, P = 0.025), V̇o2max was also associated with HbA1c ( β = −0.240, P = 0.041) independent of GRS. These results suggest that CRF is associated with HbA1c levels independent of GRS derived from T2DM-related SNPs; however, it does not modify the association of GRS with increased HbA1c or impaired β-cell function.

Visual Evoked-Response Correlates of Speechreading Performance in Normal-Hearing Adults

1983 ◽  
Vol 26 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Vincent J. Samar ◽  
Donald G. Sims
Keyword(s):  
Multiple Correlation Coefficient ◽  
Evoked Response ◽  
Multiple Correlation ◽  
Potential Significance ◽  
Visual Evoked Response ◽  
Latency Measure ◽  
Two Measures ◽  
Components Analysis ◽  
The Relationship ◽  
Visual Evoked

The relationship between the latency of the negative peak occurring at approximately 130 msec in the visual evoked-response (VER) and speechreading scores was investigated. A significant product-moment correlation of -.58 was obtained between the two measures, which confirmed the fundamental effect but was significantly weaker than that previously reported in the literature (-.90). Principal components analysis of the visual evoked-response waveforms revealed a previously undiscovered early VER component, statistically independent of the latency measure, which in combination with two other components predicted speechreading with a multiple correlation coefficient of S4. The potential significance of this new component for the study of individual differences in speechreading ability is discussed.

IMBALAN DAN GAYA KEPEMIMPINAN PENGARUHNYA TERHADAP KEPUASAN KERJA KARYAWAN DI BALAI BESAR INDUSTRI HASIL PERTANIAN BOGOR

2018 ◽  
Vol 1 (01) ◽  
pp. 17
Author(s):  
Ramlan Ruvendi
Keyword(s):  
Job Satisfaction ◽  
Multiple Regression ◽  
Correlation Coefficient ◽  
Analysis Of Variance ◽  
Partial Correlation ◽  
Multiple Correlation Coefficient ◽  
Multiple Correlation ◽  
Average Value ◽  
Partial Correlation Coefficient

The study was carried out to find out whether there were influence and correlation bet-ween : a) Reward received by the IRDABI’s employees on their job satisfaction. b) style of the leader-ship on the job satisfaction. c) Reward together with style of leadership on the job satisfaction of IR-DABI’s employees.The result of the study showed that there was significant correlation and influence between the reward on the job satisfaction with was shown by the value of partial correlation coefficient of 0.6185 and coefficient of multiple regression for reward variable (β1) of 0.412. The influence of variable for style of leadership on the job satisfaction was also significant with the partial correlation coefficient of 0.5495 and coefficient of multiple regression (β2) of 0.355.In the test of Analysis of Variance (ANOVA) on the equation of multiple regression show that F-value was bigger that F-table (F = 58.97 > F-table = 3.098) or the Probability Value smaller than 0.05. At showed that there was significant correlation and influence between reward variables all together with style of leadership on the job satisfaction of employees. The value of multiple correlation coefficient (R) was 0.751 and R Square (R2) was 0.564. Value of R Square (0.564) meant that 56.5% of variation pro-portion total of job satisfaction can be eliminated of equation of multiple regression was used as the es-timator rather than using average value of job satisfaction as the estimator.

INCRETIN AND DIABETES

2011 ◽  
pp. 5-10
Author(s):  
Huu Dang Tran
Keyword(s):  
Type 2 Diabetes ◽  
Cell Proliferation ◽  
Glycaemic Control ◽  
Animal Studies ◽  
Dipeptidyl Peptidase ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Glucose Sensitivity ◽  
Cell Glucose

The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes so drugs acting on incretins may improve glycaemic control. Incretins are metabolised by dipeptidyl peptidase, so selectively inhibiting this enzyme increases the concentration of circulating incretins. A similar effect results from giving an incretin analogue that cannot be cleaved by dipeptidyl peptidase. Studies have identified other actions including improvement in pancreatic β cell glucose sensitivity and, in animal studies, promotion of pancreatic β cell proliferation and reduction in β cell apoptosis.

Liraglutide Therapy in a Prediabetic State: Rethinking the Evidence

2020 ◽  
Vol 16 (7) ◽  
pp. 699-715 ◽  
Author(s):  
Georgios S. Papaetis
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Current Evidence ◽  
Β Cell ◽  
Prediabetic State ◽  
New Therapeutic Approaches ◽  
Normal Glucose

Background: Prediabetes is defined as a state of glucose metabolism between normal glucose tolerance and type 2 diabetes. Continuous β-cell failure and death are the reasons for the evolution from normal glucose tolerance to prediabetes and finally type 2 diabetes. Introduction: The necessity of new therapeutic approaches in order to prevent or delay the development of type 2 diabetes is obligatory. Liraglutide, a long-acting GLP-1 receptor agonist, has 97% homology for native GLP-1. Identification of the trophic and antiapoptotic properties of liraglutide in preclinical studies, together with evidence of sustained β-cell function longevity during its administration in type 2 diabetes individuals, indicated its earliest possible administration during this disease, or even before its development, so as to postpone or delay its onset. Methods: Pubmed and Google databases have been thoroughly searched and relevant studies were selected. Results: This paper explores the current evidence of liraglutide administration both in humans and animal models with prediabetes. Also, it investigates the safety profile of liraglutide treatment and its future role to postpone or delay the evolution of type 2 diabetes. Conclusion: Liralgutide remains a valuable tool in our therapeutic armamentarium for individuals who are overweight or obese and have prediabetes. Future well designed studies will give valuable information that will help clinicians to stratify individuals who will derive the most benefit from this agent, achieving targeted therapeutic strategies.

scholarly journals Impact of type 2 diabetes and microvascular complications on mortality and cardiovascular outcomes in a multiethnic Asian population

2021 ◽  
Vol 9 (1) ◽  
pp. e001413
Author(s):  
Jonathan Yap ◽  
Kamalesh Anbalakan ◽  
Wan Ting Tay ◽  
Daniel Ting ◽  
Carol Yim Cheung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Population Based ◽  
Cardiovascular Outcomes ◽  
Microvascular Complication ◽  
The Impact ◽  
Hba1c Levels

IntroductionDiabetes mellitus is a growing public health epidemic in Asia. We examined the impact of type 2 diabetes, glycemic control and microvascular complications on mortality and cardiovascular outcomes in a multiethnic population-based cohort of Asians without prior cardiovascular disease.Research design and methodsThis was a prospective population-based cohort study in Singapore comprising participants from the three major Asian ethnic groups: Chinese, Malays and Indians, with baseline examination in 2004–2011. Participants with type 1 diabetes and those with cardiovascular disease at baseline were excluded. Type 2 diabetes, Hemoglobin A1c (HbA1c) levels and presence of microvascular complications (diabetic retinopathy and nephropathy) were defined at baseline. The primary outcome was all-cause mortality and major adverse cardiovascular events (MACEs), defined as a composite of cardiovascular mortality, myocardial infarction, stroke and revascularization, collected using a national registry.ResultsA total of 8541 subjects were included, of which 1890 had type 2 diabetes at baseline. Subjects were followed for a median of 6.4 (IQR 4.8–8.8) years. Diabetes was a significant predictor of mortality (adjusted HR 1.74, 95% CI 1.45 to 2.08, p<0.001) and MACE (adjusted HR 1.64, 95% CI 1.39 to 1.93, p<0.001). In those with diabetes, higher HbA1c levels were associated with increased MACE rates (adjusted HR (per 1% increase) 1.18, 95% CI 1.11 to 1.26, p<0.001) but not mortality (p=0.115). Subjects with two microvascular complications had significantly higher mortality and MACE compared with those with only either microvascular complication (adjusted p<0.05) and no microvascular complication (adjusted p<0.05).ConclusionDiabetes is a significant predictor of mortality and cardiovascular morbidity in Asian patients without prior cardiovascular disease. Among patients with type 2 diabetes, poorer glycemic control was associated with increased MACE but not mortality rates. Greater burden of microvascular complications identified a subset of patients with poorer outcomes.

scholarly journals Visceral Adiposity Index is associated with Insulin Resistance, impaired Insulin Secretion, and β-cell dysfunction in subjects at risk for Type 2 Diabetes

2021 ◽  
pp. 100013
Author(s):  
Froylan David Martínez-Sánchez ◽  
Valerie Paola Vargas-Abonce ◽  
Andrea Rocha-Haro ◽  
Romina Flores-Cardenas ◽  
Milagros Fernández-Barrio ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
At Risk ◽  
Insulin Secretion ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Β Cell ◽  
Cell Dysfunction ◽  
Impaired Insulin
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