scholarly journals Seroprevalence of HCMV among Pregnant Women and Its relation to CD4 and CRP

2018 ◽  
pp. 166-171
Author(s):  
Staar Mohammed Qader
Keyword(s):  
Pregnant Women ◽  
Host Specificity ◽  
Intrauterine Infection ◽  
Etiological Agent ◽  
Igg Antibodies ◽  
Viral Pathogen ◽  
Cerebellar Malformation ◽  
Medical Laboratories ◽  
Developmental Retardation ◽  
Cd4 Percentage

The HCMV is a widespread viral pathogen characterized by strict host specificity and is limited to humans. It has been described as an important etiological agent of intrauterine infection in during the pregnancy, which may lead to some serious results such as miscarriage, cerebellar malformation stillbirth, and fetus developmental retardation. The study carried out in Kirkuk governorate from the December 2017 to May 2018 for study the relation of CD4 percentage and CRP with HCMV seropositive pregnant women. The number of pregnant women under study was two hundred women attending to some private medical laboratories in Kirkuk. The pregnant women were examined for the seroprevalence of HCMV IgM and IgG antibodies by using VIDAS technique. The results were (81 %), (9%) and (6%) for HCMV-IgG, HCMV-IgM and for both IgG & IgM at the same time respectively. The highest rates (41.66%) of decreased CD4 percentage were within seropositive pregnant women for both IgG & IgM at same time, while the highest rates (16.66%)of CRP positive were found within HCMV-IgM seropositive group.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

Ultrasound and clinical-morphological evaluation of fetal-placental complex of pregnant women with intrauterine infection

GYNECOLOGY ◽  
2015 ◽  
Vol 17 (5) ◽  
pp. 10-13
Author(s):  
S.M. Voevodin ◽  
◽  
T.V. Shemanaeva ◽  
A.I. Shchegolev ◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Infection ◽  
Morphological Evaluation

scholarly journals Seroprevalence of rubella-specific IgM and IgG antibodies among pregnant women in a Catholic Hospital in Yaoundé, Cameroon

2018 ◽  
Vol 12 (3) ◽  
pp. 1123
Author(s):  
Anna Aret Eno ◽  
Louise Stéphanie Makemgue ◽  
Daves Stéphane Tonye III ◽  
Cheikh Saad Bouh Boye ◽  
Abdoulaye Seck ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Igg Antibodies ◽  
Catholic Hospital

Parvovirus infection in children and pregnant women

2021 ◽  
Vol 19 (2) ◽  
pp. 119-125
Author(s):  
E.V. Mikhailova ◽  
◽  
T.K. Chudakova ◽  
D.Yu. Levin ◽  
A.V. Romanovskaya ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Ex Vivo ◽  
Parvovirus B19 ◽  
Virus Transmission ◽  
Intrauterine Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Minute Virus Of Mice ◽  
Gestation Age ◽  
B19 Parvovirus ◽  
Minute Virus

Parvovirus (PV) is a widespread infection, despite the fact that this pathogen was discovered only recently. The therapeutic effect of PV, in particular its oncolytic activity, is being actively studied now. Notably, PVs causing infections in animals, such as rat PV H-1, caninae PV, and rodent protoparvovirus (minute virus of mice) suppress oncogenesis in these animals. There is an ex vivo evidence of rat glioblastoma and gliosarcoma sensitivity to PV. The affinity of PV B19 to P-antigen located primarily on the membranes of erythroid cells is crucial for the disease pathogenesis. The teratogenic effect of PV B19 is associated with its ability to infect placental cells (P-antigen is present on the cells of chorionic villi and surface of the trophoblast). PV infection can be acquired or congenital, typical or atypical. The outcome of intrauterine infection with PV B19 largely depends on the gestation age when the infection occurred. Women infected during the second trimester are at higher risk of vertical transmission and severe intrauterine pathology with a poor outcome than those infected during the third trimester. Constant contact with young children significantly increases the risk of PV B19 infection among pregnant women with no immunity to this virus. Serum is the most convenient biomaterial for detecting both PV DNA and virus-specific antibodies. One test for anti-PV IgG using enzyme-linked immunosorbent assay is sufficient to determine the immune status of a patient. Polymerase chain reaction with amniotic fluid is used to diagnose intrauterine infection with PV B19. Blood components and products should be checked for PV B19. High frequency of PV B19 detection in the blood of donors necessitates the development of special measures aimed at prevention of virus transmission. Key words: pregnant women, children, parvovirus B19, parvovirus infection

Effectiveness of pregravid preparation in women of high infectious risk

2018 ◽  
pp. 31-35
Author(s):  
T.G. Romanenko ◽  
◽  
O.M. Sulimenko ◽  
Keyword(s):  
High Risk ◽  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Risk Group ◽  
Intrauterine Infection ◽  
Vaginal Candidiasis ◽  
Placental Dysfunction ◽  
Infectious Risk ◽  
Group I ◽  
Group Ii

The article presents the results of the effectiveness of the combined antimicrobial drug Guinex Forte, the effect of which is caused by metronidazole and miconazole, and the Orgil tablets at the stage of pregravid preparation in women of high-risk group, with regard to the development of placental insufficiency of infectious genesis and intrauterine infection. The objective: is to demonstrate the effectiveness of pregravid preparation for the normalization of vaginal biocenosis in pregnant women of high infectious risk. Materials and methods. 150 pregnant women were investigated, of which 100 with a high risk of infectious risk for placental dysfunction and intrauterine infection: Group I – 50 pregnant women who did not undergo pregravid preparation; Group II – 50 pregnant women who planned pregnancy and conducted pregravid preparation for prevention and treatment of bacterial vaginosis and vaginal candidiasis; Control group consisted of 50 pregnant women who gave birth again, without obstetrical and extragenital pathology in history. per vaginum. Results. In pregnant women in Group II, an intermediate type of dysbiosis was 1.2 times less likely than in pregnant women of group I, and vice versa, normocenosis was achieved 9.7 times more often in pregnant women who received pregravid preparation. After the therapy in the pregravid period, in pregnant women of group II in the first trimester of pregnancy quantitative and qualitative indices of biocenosis of the vagina were approaching, in most cases, to normal. In general, the spectrum of the microflora decreased from 21 to 14 species due to the reduction of pathogenic forms of staphylococci, streptococci, enterobacteria, E. coli, klebsiela, cornebacteria and clostridia. In patients of group II, the concentration of representatives of resident flora increased (lactobacillus Lg 5.06±0.7 CFU / ml and bifidobacterium-Lg 4.4±0.6 CFU / ml) and close to normal. Conclusion. Our proposed scheme of therapy and prevention of dysbiotic conditions in the pregravid period, in women of high infectious risk group led to a decrease in bacterial contamination of maternity paths of pregnant women in group II, which contributes to the restoration of vaginal microbiocenosis and positively affects the course of pregnancy, the condition of the fetus and the newborn. Key words: pregravid preparation, bacterial vaginosis, vulvovaginal candidiasis, placental dysfunction of infectious genesis, intrauterine infection.

Antibody Testing of Infants Born to Asymptomatic COVID-19 Positive Mothers

2021 ◽  
Vol 16 (10) ◽  
pp. 3-7
Author(s):  
Tonya Robinson ◽  
Nicole Pozzi ◽  
Saeed Jortani
Keyword(s):  
Pregnant Women ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Igg Antibodies ◽  
Rt Pcr ◽  
Antibody Testing ◽  
University Of Louisville ◽  
Specific Igg ◽  
Negative Conclusion ◽  
Future Management

Awareness of SARS-COV-2 IgG may contribute to the management of asymptomatic RT PCR COVID-19 positive pregnant women, their newborns, and future vaccination practices. Objective: Characterize COVID testing results of asymptomatic COVID-19 positive pregnant women and their infants. Our assumption/hypothesis maintained that all infants born to asymptomatic COVID-19 positive mothers would have detectable SARS-CoV-2 specific IgG. Study Design: Retrospective chart review. Clinical demographics/COVID-19 testing of maternal/infant dyads were reviewed/collected for reporting purposes. Setting: Center for Women and Infants (CWI), University of Louisville Hospital, Louisville, KY Participants: Asymptomatic COVID-19 positive pregnant women/infant dyads admitted to the CWI between June 2020 to February 2021. Results: 36 COVID-19 positive asymptomatic mother/37 infant dyads (one set of twins) reviewed. 38% of the mother/infant dyads were positive for SARS-CoV-2 IgG, while 27% of mother/infant dyads were negative for IgG. A COVID-19 positive mother of twins was IgG negative, but both twins were positive. Two mothers in this study group had developed significant COVID-19 disease at 28w4d gestation and 34w0d gestation. Both required intensive care but recovered, and their pregnancies were maintained until 37w4d and 39w3d gestation, respectively. By the time of delivery, both mothers had negative COVID-19 RT PCR testing, but both infants were positive for SARS-CoV-2 IgG antibodies. COVID-19 RT PCR testing on both of these infants at 24 and 48 hours of age was negative. Conclusion: SARS-CoV-2 IgG is passively transferred to the infant during pregnancy of asymptomatic positive COVID-19 mothers however appears variable and/or possibly based on the ability of IgG detection with current testing. Further investigation of the immune system’s response to the SARS-CoV-2 virus during pregnancy can direct future management/treatment during pregnancy, especially in the wake of vaccination for the virus during pregnancy and emerging variants.

scholarly journals Seroprevalence of rubella-specific IgM and IgG antibodies among pregnant women seen in a tertiary hospital in Nigeria

2015 ◽  
pp. 75
Author(s):  
Maryam Aminu ◽  
Okikiola Olajide ◽  
Abdullahi, Jibril Randawa ◽  
Daniel, Stephen Adejo
Keyword(s):  
Pregnant Women ◽  
Tertiary Hospital ◽  
Igg Antibodies

scholarly journals CD4 Percentage and Absolute CD4 Accuracy not Different in Predicting Viral Load of HIVInfected Mothers

2016 ◽  
Author(s):  
Ferry Santoso ◽  
Ketut Suwiyoga ◽  
I Gede M Putra
Keyword(s):  
Viral Load ◽  
Pregnant Women ◽  
Obstet Gynecol ◽  
Diagnostic Study ◽  
Consecutive Sampling ◽  
Significant Difference ◽  
Accuracy Difference ◽  
Cd4 Percentage ◽  
Sensitivity Specificity ◽  
Biology Laboratory

Objective: To determine the accuracy difference between CD4 percentage and absolute CD4 in predicting the viral load of HIV-infected pregnant women. Methods: This study is a diagnostic study involving 22 HIV-infected pregnant women who came for PMTCT at the Outpatient Clinic in Sanglah Hospital, from September 2011 until August 2012, who were randomly selected through consecutive sampling. Blood samples were collected to analyze the viral load, CD4, and complete blood count (CBC). Viral load examination was conducted using PCR in the molecular biology laboratory in the Faculty of Medicine University of Udayana. CD4 and CBC test was conducted in Sanglah Hospital Laboratory. Analysis was done with 2x2 table using SPSS for windows® version 17 to evaluate sensitivity, specificity and accuracy rate of CD4 percentage and absolute CD4 in predicting the viral load. Results: Data analysis shows that CD4 percentage had 75.0% sensitivity, 88.9% specificity, and accuracy of 86.4% for predicting the viral load in HIV-infected pregnant women. Meanwhile, absolute CD4 had 50.0% sensitivity, 77.8% specificity, and 72.7% accuracy. Chisquare test shows that there was no significant difference in the accuracy of CD4 percentage and absolute CD4 (p=0.457). Conclusion: CD4 percentage and absolute CD4 had high accuracy in predicting the viral load in HIV-infected pregnant women (86.4% and 72.7%). There was no significant difference of accuracy between the CD4 percentage and absolute CD4. [Indones J Obstet Gynecol 2015; 3-4: 230-233] Keywords: CD4, HIV-infected pregnant women, viral load

scholarly journals The influence of urogenital infections on pregnancy, condition of foetus and neonate

2002 ◽  
Vol 1 (1) ◽  
pp. 84-88
Author(s):  
T. V. Gabidulina ◽  
E. L. Timoshina ◽  
S. Yu. Yuryev ◽  
A. Sh. Makhmuthodzhayev
Keyword(s):  
Pregnant Women ◽  
Intrauterine Infection ◽  
Virus Infections ◽  
Urogenital Infections ◽  
Intrauterine Infections

It is proved that intrauterine infections influence negatively on the period of pregnancy, the condition of fetus and newborn on the example of isolated, chlamydeous and chlamydeous-virus infections. The schemes of treatment of pregnant women in these groups are determined. It is revealed that the percentage of the possibility and the degree of heaviness of intrauterine infection is lowing if the newborn were born by women who got the treatment in the period of pregnancy.

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