Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats

2016 ◽  
Vol 3 (2) ◽  
pp. 57-62
Author(s):  
Hai-Lin Zhao ◽  
Da-Qing Ma ◽  
Niccolò Terrando
Keyword(s):  
Postnatal Exposure

scholarly journals Neurotoxicological Examination of the Piglet Brain after Prenatal and Postnatal Exposure to Trichlorfon

1987 ◽  
Vol 28 (3-4) ◽  
pp. 313-320 ◽  
Author(s):  
Gunnar N. Berge ◽  
Frode Fonnum ◽  
Nils E. Søli ◽  
Erling Segnen
Keyword(s):  
Postnatal Exposure

scholarly journals Residue Levels of Organochlorine Pesticides in Breast Milk and Its Associations with Cord Blood Thyroid Hormones and the Offspring’s Neurodevelopment

2019 ◽  
Vol 16 (8) ◽  
pp. 1438 ◽  
Author(s):  
Cheng-Chih Kao ◽  
Danielle E. Que ◽  
Sayre J. Bongo ◽  
Lemmuel L. Tayo ◽  
Yi-Hsien Lin ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cord Blood ◽  
Negative Impact ◽  
Growth Hormones ◽  
Exposure Group ◽  
Linear Regression Models ◽  
Postnatal Exposure ◽  
Social Emotional ◽  
Neurodevelopmental Outcomes ◽  
Infant Neurodevelopment

Previous studies have demonstrated that organochlorine pesticide (OCP) exposure has a negative impact on the neurological function of infants. Only a few reports have investigated the thyroid and growth hormones and their relationship to neurodevelopment after human exposure to OCPs, especially in the case of infants. Our goal was to determine whether breastmilk OCP residues were associated with negative impacts and/or alterations in the neurodevelopment of infants among specific southern Taiwanese mother–breastfed infant pairs. Our subjects (n = 55 pairs) were recruited from southern Taiwan between 2007 and 2010. The thyroid and growth hormone levels in the cord blood samples collected after childbirth were determined. The breastmilk was gathered within one month after childbirth for the determination of OCP levels using a high-resolution gas chromatograph with mass spectrometry, and the neurodevelopment of 10–12-month-old infants was examined using the Bayley Scales of Infant and Toddler Development®, Third Edition (Bayley-III). It was observed that 4,4′-dichlorodiphenyl-dichloroethylene (4,4′-DDE) (mean = 10.3 ng/g lipid) was the most predominant OCP compound in the breastmilk samples. At higher concentrations (>75th percentile), specific OCPs were associated with significantly lower levels of thyroid and growth hormones than at lower concentrations (<75th percentile). Significantly higher odds ratios (ORs) were observed for binary cognitive (OR = 8.09, p = 0.025 for 4,4′-DDT), language (OR = 11.9, p = 0.013 for 4,4′-DDT) and social–emotional (OR = 6.06, p = 0.01 for trans-CHL) composite scores for specific OCPs belonging to the lower exposure group as compared to the higher OCP exposure group. The five domain Bayley-III infant neurodevelopment outcomes were negatively associated with specific OCPs in the breast milk samples based on the redundancy analysis (RDA) test. Bayley-III scales, which include cognitive, language, motor, social-emotional, and adaptive behavior scales, could be predicted by 4,4′-DDT, endrin, endosulfan I, heptachlor, or heptachlor epoxide using multivariate linear regression models with adjustment for maternal age, pre-pregnant BMI, parity, and infant gender. In conclusion, although our study showed that postnatal exposure to breast milk OCPs may be associated with infant neurodevelopmental outcomes and that prenatal exposure, if extrapolated from breastmilk levels, is associated with changes in thyroid and growth hormones that may have effects on neurodevelopment, these associations are only suggestive; thus, further studies are recommended for confirmation.

scholarly journals Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts

2021 ◽  
Author(s):  
Silvia Alemany ◽  
Claudia Avella-García ◽  
Zeyan Liew ◽  
Raquel García-Esteban ◽  
Kosuke Inoue ◽  
...  
Keyword(s):  
Attention Deficit ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Collaborative Study ◽  
Population Based ◽  
Autism Spectrum ◽  
European Population ◽  
Autism Spectrum Conditions ◽  
Adhd Symptoms ◽  
Postnatal Exposure

AbstractThe potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative study of six European population-based birth/child cohorts. A total of 73,881 mother–child pairs were included in the study. Prenatal and postnatal (up to 18 months) acetaminophen exposure was assessed through maternal questionnaires or interviews. ASC and ADHD symptoms were assessed at 4–12 years of age using validated instruments. Children were classified as having borderline/clinical symptoms using recommended cutoffs for each instrument. Hospital diagnoses were also available in one cohort. Analyses were adjusted for child and maternal characteristics along with indications for acetaminophen use. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. The proportion of children having borderline/clinical symptoms ranged between 0.9 and 12.9% for ASC and between 1.2 and 12.2% for ADHD. Results indicated that children prenatally exposed to acetaminophen were 19% and 21% more likely to subsequently have borderline or clinical ASC (OR = 1.19, 95% CI 1.07–1.33) and ADHD symptoms (OR = 1.21, 95% CI 1.07–1.36) compared to non-exposed children. Boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys. Postnatal exposure to acetaminophen was not associated with ASC or ADHD symptoms. These results replicate previous work and support providing clear information to pregnant women and their partners about potential long-term risks of acetaminophen use.

scholarly journals Pre- and Postnatal Exposure to Low Dose Glufosinate Ammonium Induces Autism-Like Phenotypes in Mice

2014 ◽  
Vol 8 ◽  
Author(s):  
Anthony Laugeray ◽  
Ameziane Herzine ◽  
Olivier Perche ◽  
Betty Hébert ◽  
Marine Aguillon-Naury ◽  
...  
Keyword(s):  
Low Dose ◽  
Postnatal Exposure ◽  
Glufosinate Ammonium
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