p38 MAPK Inhibitor Administration Provides Protection against Acute Lung Injury in Rats with Intestinal Ischemia Reperfusion Via Downregulating Interlukin-6 Expression

2016 ◽  
Vol 3 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Liu-Lin Xiong ◽  
Yun-Xia Zuo ◽  
Chao-Zhi Luo ◽  
Jie Yu ◽  
Qing-Jie Xia ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
P38 Mapk ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
P38 Mapk Inhibitor ◽  
Intestinal Ischemia Reperfusion ◽  
Mapk Inhibitor

scholarly journals Corrigendum to: Acute Lung Injury in A Rat Model Of Intestinal Ischemia-Reperfusion: The Potential Time Depended Role Of Phospholipases

2021 ◽  
Vol 263 ◽  
pp. 291
Author(s):  
Georgia Kostopanagiotou ◽  
Efthimios Avgerinos ◽  
Konstantinos Kostopanagiotou ◽  
Nikolaos Arkadopoulos ◽  
Ioanna Andreadou ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

scholarly journals Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation

2018 ◽  
Vol 46 (2) ◽  
pp. 781-792 ◽  
Author(s):  
DongDong Chai ◽  
Lei Zhang ◽  
SiWei Xi ◽  
YanYong Cheng ◽  
Hong Jiang ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Vegf Expression ◽  
Intestinal Ischemia Reperfusion ◽  
Cd31 Expression

Background/Aims: Nuclear erythroid 2-related factor-2 (Nrf2) is a major stress-response transcription factor that has been implicated in regulating ischemic angiogenesis. We investigated the effects of Nrf2 in regulating revascularization and modulating acute lung injury. Methods: The expression of Nrf2 and sirtuin1 (Sirt1) was assessed in lung tissue by western blotting and immunofluorescence staining after intestinal ischemia/reperfusion (IIR) in Nrf2–/– and wild-type (WT) mice. The involvement of Nrf2 in angiogenesis, cell viability, and migration was investigated in human pulmonary microvascular endothelial cells (PMVECs). Additionally, the influence of Nrf2 expression on NOX pathway activation was measured in PMVECs after oxygen–glucose deprivation/reoxygenation. Results: We found activation and nuclear accumulation of Nrf2 in lung tissue after IIR. Compared to IIR in WT mice, IIR in Nrf2–/– mice significantly enhanced leukocyte infiltration and collagen deposit, and inhibited endothelial cell marker CD31 expression. Nrf2 upregulation and translocation into the nucleus stimulated by Sirt1 overexpression exhibited remission of histopathologic changes and enhanced CD31 expression. Nrf2 knockdown repressed non-phagocytic cell oxidase 4 (NOX4), hypoxia-inducible factor (HIF-1α) and vascular endothelial growth factor (VEGF) expression after IIR. Nrf2 upregulation by Sirt1 enhances NOX4, HIF-1α and VEGF expression after IIR in WT mice. Furthermore, Nrf2 knockdown suppressed cell viability, capillary tube formation and cell migration in PMVECs after oxygen–glucose deprivation/reoxygenation and also inhibited NOX4, HIF-1 and VEGF expression. Moreover, NOX4 knockdown in PMVECs decreased the levels of VEGF, HIF-1α and angiogenesis. Conclusion: Nrf2 stimulation by Sirt1 plays an important role in sustaining angiogenic potential through NOX4-mediated gene regulation.

scholarly journals Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jee Hyun Kim ◽  
Jihye Kim ◽  
Jaeyoung Chun ◽  
Changhyun Lee ◽  
Jong Pil Im ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

scholarly journals Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

Aging ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 12943-12959 ◽  
Author(s):  
Hui Dong ◽  
Zhuanzhuan Qiang ◽  
Dongdong Chai ◽  
Jiali Peng ◽  
Yangyang Xia ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

scholarly journals Author Correction: Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jee Hyun Kim ◽  
Jihye Kim ◽  
Jaeyoung Chun ◽  
Changhyun Lee ◽  
Jong Pil Im ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion
Sign in / Sign up

Export Citation Format

Share Document