scholarly journals The Reconstruction of the Proto-Semitic Genitive Ending and a Suggestion on its Origin

2021 ◽  
Vol 9 (1) ◽  
pp. 66-82
Author(s):  
Benjamin Suchard
Keyword(s):  
Bound State ◽  
Final Position ◽  
Hypothetical Scenario ◽  
Singular Noun ◽  
Genitive Case

The Proto-Semitic genitive ending on triptotic nouns is commonly reconstructed as *-im (unbound state)/*-i (bound state). In Akkadian, however, this case ending is long -ī- before pronominal suffixes. Since the length of this vowel is unexplained, I argue that it is original and that the Akkadian bound state ending -i should also be reconstructed as long *-ī, explaining its retention in word-final position. This form seems more original than Proto-West-Semitic *-i. Hence, the Proto-Semitic bound state genitive ending should also be reconstructed as *-ī. Through internal reconstruction supported by the parallel of kinship terms like *ʔab-um ‘father’, I arrive at a pre-Proto-Semitic reconstruction of the genitive ending as *-ī-m (unbound), *-ī (bound). This paper then explores a hypothetical scenario where the genitive ending *-ī is derived from the adjectivizing ‘nisbe’ suffix through reanalysis of adjectival constructions like *bayt-u śarr-ī ‘the/a royal house’ as construct chains with meanings like ‘the/a king’s house’; with the addition of mimation and the resultant vowel shortening, this yielded the Proto-Semitic construction with a genitive, *bayt-u śarr-im. The genitive case failed to develop with diptotic nouns because they did not take mimation and in the dual and plural because the nisbe adjective was derived from the uninflected (singular) noun stem; hence, these categories all retain the more original contrast between the nominative and and an undifferentiated oblique case.

CRYO-Electron Microscopy of the Acto-Myosin-ATP Complex

1990 ◽  
Vol 48 (1) ◽  
pp. 248-249
Author(s):  
John Trinickt ◽  
Howard White
Keyword(s):  
Electron Microscopy ◽  
Atp Hydrolysis ◽  
Myosin Head ◽  
Bound State ◽  
Cross Linking ◽  
Weakly Bound ◽  
Cryo Electron Microscopy ◽  
Myosin Subfragment 1 ◽  
Attached State ◽  
High Fraction

The primary force of muscle contraction is thought to involve a change in the myosin head whilst attached to actin, the energy coming from ATP hydrolysis. This change in attached state could either be a conformational change in the head or an alteration in the binding angle made with actin. A considerable amount is known about one bound state, the so-called strongly attached state, which occurs in the presence of ADP or in the absence of nucleotide. In this state, which probably corresponds to the last attached state of the force-producing cycle, the angle between the long axis myosin head and the actin filament is roughly 45°. Details of other attached states before and during power production have been difficult to obtain because, even at very high protein concentration, the complex is almost completely dissociated by ATP. Electron micrographs of the complex in the presence of ATP have therefore been obtained only after chemically cross-linking myosin subfragment-1 (S1) to actin filaments to prevent dissociation. But it is unclear then whether the variability in attachment angle observed is due merely to the cross-link acting as a hinge.We have recently found low ionic-strength conditions under which, without resorting to cross-linking, a high fraction of S1 is bound to actin during steady state ATP hydrolysis. The structure of this complex is being studied by cryo-electron microscopy of hydrated specimens. Most advantages of frozen specimens over ambient temperature methods such as negative staining have already been documented. These include improved preservation and fixation rates and the ability to observe protein directly rather than a surrounding stain envelope. In the present experiments, hydrated specimens have the additional benefit that it is feasible to use protein concentrations roughly two orders of magnitude higher than in conventional specimens, thereby reducing dissociation of weakly bound complexes.

When Death Is Compelling

2015 ◽  
Vol 46 (6) ◽  
pp. 352-360 ◽  
Author(s):  
Simon Schindler ◽  
Marc-André Reinhard
Keyword(s):  
Terror Management Theory ◽  
Mortality Salience ◽  
Terror Management ◽  
Management Theory ◽  
Control Group ◽  
Norms And Values ◽  
Hypothetical Scenario ◽  
The Face ◽  
Scenario Study ◽  
Norm Of Reciprocity

Abstract. Research on terror management theory has found evidence that people under mortality salience strive to live up to activated social norms and values. Recently, research has shown that mortality salience also increases adherence to the norm of reciprocity. Based on this, in the current paper we investigated the idea that mortality salience influences persuasion strategies that are based on the norm of reciprocity. We therefore assume that mortality salience should enhance compliance for a request when using the door-in-the-face technique – a persuasion strategy grounded in the norm of reciprocity. In a hypothetical scenario (Study 1), and in a field experiment (Study 2), applying the door-in-the-face technique enhanced compliance in the mortality salience condition compared to a control group.

Mislocalization of the Initial and Final Position of a Moving Stimulus

2000 ◽  
Author(s):  
Jochen Musseler ◽  
Sonja Stork ◽  
Dirk Kerzel ◽  
J. Scott Jordan
Keyword(s):  
Final Position ◽  
Moving Stimulus

The interpretation of singular nouns in the scope of an event-distributive quantifier

2019 ◽  
Vol 5 (1) ◽  
pp. 1-9
Author(s):  
Piotr Gulgowski
Keyword(s):  
Present Experiment ◽  
Multiple Objects ◽  
Multiple Events ◽  
Singular Noun ◽  
Distributive Operator

Abstract Singular nouns in the scope of a distributive operator have been shown to be treated as conceptually plural (Patson and Warren, 2010). The source of this conceptual plurality is not fully clear. In particular, it is not known whether the concept of plurality associated with a singular noun originates from distributing over multiple objects or multiple events. In the present experiment, iterative expressions (distribution over events) were contrasted with collective and distributive sentences using a Stroop-like interference technique (Berent, Pinker, Tzelgov, Bibi, and Goldfarb, 2005; Patson and Warren, 2010). A trend in the data suggests that event distributivity does not elicit a plural interpretation of a grammatically singular noun, however the results were not statistically significant. Possible causes of the non-significant results are discussed.

Binding Mechanism and Structural Insights into the Identified Protein Target of Covid-19 with In-Vitro Effective Drug Ivermectin

2020 ◽  
Author(s):  
Parth Sarthi Sen Gupta ◽  
Satyaranjan Biswal ◽  
Saroj Kumar Panda ◽  
Abhik Kumar Ray ◽  
Malay Kumar Rana
Keyword(s):  
Ternary Complex ◽  
Bound State ◽  
Molecular Target ◽  
Cooperative Interaction ◽  
Effective Drug ◽  
Rna Dependent Rna Polymerase ◽  
Protein Target ◽  
Ternary Complex Formation ◽  
Structural Insights

<p>While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by ~5000 folds within 48 hours, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro effective drug are unknown yet. Among 12 different COVID-19 targets studied here, the RNA dependent RNA polymerase (RdRp) with RNA and Helicase NCB site show the strongest affinity to Ivermectin amounting -10.4 kcal/mol and -9.6 kcal/mol, respectively. Molecular dynamics of corresponding protein-drug complexes reveals that the drug bound state of RdRp with RNA has better structural stability than the Helicase NCB site, with MM/PBSA free energy of -135.2 kJ/mol, almost twice that of Helicase (-76.6 kJ/mol). The selectivity of Ivermectin to RdRp is triggered by a cooperative interaction of RNA-RdRp by ternary complex formation. Identification of the target and its interaction profile with Ivermectin can lead to more powerful drug designs for COVID-19 and experimental exploration. </p>

The impact of a physician’s recommendation and gender on informed decision making: A randomized controlled study in a simulated decision situation

2020 ◽  
Author(s):  
Marie Eggeling ◽  
Anna Meinhardt ◽  
Ulrike Cress ◽  
Joachim Kimmerle ◽  
Martina Bientzle
Keyword(s):  
Decision Making ◽  
Cruciate Ligament ◽  
Treatment Options ◽  
General Information ◽  
Treatment Preference ◽  
Controlled Study ◽  
Treatment Preferences ◽  
Hypothetical Scenario ◽  
And Gender ◽  
The Impact

Objective: This study examined the influence of physicians’ recommendations and gender on the decision-making process in a preference-sensitive situation. Methods: N = 201 participants were put in a hypothetical scenario in which they suffered from a rupture of the anterior cruciate ligament (ACL). They received general information on two equally successful treatment options for this injury (surgery vs. physiotherapy) and answered questions regarding their treatment preference, certainty and satisfaction regarding their decision, and attitude toward the treatment options. Then participants watched a video that differed regarding physician’s recommendation (surgery vs. physiotherapy) and physician’s gender (female vs. male voice and picture). Afterward, they indicated again their treatment preference, certainty, satisfaction, and attitude, as well as the physician’s professional and social competence.Results: Participants changed their treatment preferences in the direction of the physician’s recommendation (P&lt;.001). Decision certainty (P&lt;.001) and satisfaction (P&lt;.001) increased more strongly if the physician’s recommendation was congruent with the participant’s prior attitude than if the recommendation was contrary to the participant’s prior attitude. Finally, participants’ attitudes toward the recommended treatment became more positive (surgery recommendation: P&lt;.001; physiotherapy recommendation: P&lt;.001). We found no influence of the physician’s gender on participants’ decisions, attitudes, or competence assessments.Conclusion: This research indicates that physicians should be careful with recommendations when aiming for shared decisions, as they might influence patients even if the patients have been made aware that they should take their personal preferences into account. This could be particularly problematic if the recommendation is not in line with the patient’s preferences.

INOVASI FONOLOGIS DENASALISASI DALAM ISOLEK BONAI ULAKPATIAN

2017 ◽  
Vol 6 (2) ◽  
pp. 235
Author(s):  
Yanti Riswara
Keyword(s):  
Historical Linguistic ◽  
Language Variation ◽  
Final Position ◽  
Process Data ◽  
Top Down ◽  
Linguistic Study ◽  
Oral Speech ◽  
Research Findings

The paper is aimed at describing a language variation, that is Ulakpatian Bonai isolect  in Riau Province. This is a kind of historical linguistic study which  is objected to describe a phonological inovation process of denasalisation among nasal phonemes at final positions or at close ultimate sillables in an isolect used by Bonai tribe in Ulakpatian, Rokan Hulu District,  Riau  Province.  Analysis  of  inavation is based on protomalayic (PM)  which  is reconstructed by Adelaar.The research applicates  top-down method of anaysis which are gaining  the  results by deductive process. Data of  this  research are oral  speech of Bonai people  based  on  200  Swadesh  words.  The  data  are  gathered  by  conversational  and listening  methods  which  applied  several  techniques.  The  results  of  the  analysis  are presented by formal and informal methods. The research findings reveal that the language of the tribe shows three kinds of denasalisation of phonological innovation at final position which  have  changed  the  nasal  phonemes  of  *PM  to  unnasal  ones  in  isolek  Bonai Ulakpatian: (*PM > BU) , i.e. 1) PM *n/-# > []/-#, 2) PM *m/-# > [p]/-#, dan 3) PM * /-# > [g]/-#.Abstrak  Makalah ini bertujuan untuk mendeskripsikan sebuah variasi bahasa, yaitu isolek Bonai Ulakpatian yang terdapat di Provinsi Riau. Kajian ini merupakan kajian linguistik historis yang memaparkan proses inovasi fonologis denasalisasi yang terjadi pada fonem-fonem nasal yang berada pada posisi akhir atau silabe ultima tertutup dalam sebuah isolek yang digunakan oleh suku Bonai di Desa Ulakpatian, Kabupaten Rokan Hulu. Analisis inovasi fonologis tersebut didasarkan pada protomalayik (PM) yang direkonstruksi oleh Adelaar. Kajian ini menerapkan mentode analisis top-down yang bersifat deduktif. Data penelitian merupakan data tuturan masyarakat suku Bonai yang mengacu pada 200 kosakata dasar yang dijadikan rujukan dalam penjaringan data kebahasaan. Data dikumpulkan dengan penerapan metode cakap dan metode simak dengan menggunakan teknik pancing dan teknik rekam. Data dideskripsikan secara fonetis dengan simbol IPA. Hasil penelitian disajikan dengan metode formal dan informal. Hasil penelitian menunjukkan bahwa isolek Bonai Ulakpatian memiliki tiga bentuk inovasi fonologis denasalisasi pada posisi akhir beberapa fonem nasal *PM menjadi taknasal pada isolek BU (*PM > BU) , yaitu 1) PM *n/-# > []/-#, 2) PM *m/-# > [p]/-#, dan 3) PM * /-# > [g]/-#.

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