scholarly journals Branchial cleft cyst presenting as metastatic squamous carcinoma in fine needle aspirates: report of three cases

2013 ◽  
Vol 3 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Murat Songu
Keyword(s):  
Squamous Carcinoma ◽  
Branchial Cleft Cyst ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Branchial Cleft

p53 Immunolocalization in Cell Block Preparations of Squamous Lesions of the Neck: An Adjunct to Fine-Needle Aspiration Diagnosis of Malignancy

1999 ◽  
Vol 123 (5) ◽  
pp. 421-425
Author(s):  
Kamal K. Khurana ◽  
Ibrahim Ramzy ◽  
Luan D. Truong
Keyword(s):  
Fine Needle Aspiration ◽  
P53 Protein ◽  
Needle Aspiration ◽  
Protein Accumulation ◽  
Branchial Cleft Cyst ◽  
Cytologic Diagnosis ◽  
Fine Needle ◽  
Squamous Cells ◽  
Branchial Cleft

Abstract Objective.—Mutations of the p53 tumor suppressor gene, with consequent nuclear p53 protein accumulation, are among the most common genetic abnormalities in human cancers. The purpose of this study was to determine the utility of p53 immunostaining as an adjunct to the diagnosis of malignancy in fine-needle aspirations of squamous lesions of the neck. Materials and Methods.—Using a monoclonal antibody to the p53 protein and a standard avidin-biotin complex technique, immunostaining was performed on paraffin-embedded cell blocks of 20 cases with the following cytologic diagnoses: (1) metastatic squamous cell carcinoma (SCC) (7 cases); (2) atypical squamous cells, SCC cannot be excluded (7 cases); and (3) cytologic findings consistent with branchial cleft cyst (6 cases). Tissue or clinical follow-up was available in all cases. Results.—Five (71%) of 7 cases with an unequivocal cytologic diagnosis of metastatic SCC were positive for p53 protein. Tissue follow-up confirmed metastatic SCC in all of these 7 cases. Of the 7 cases with cytologic diagnosis of atypical squamous cells, 2 were negative and 5 (71%) were positive for p53 protein. Subsequent excisional biopsies in these cases revealed metastatic SCC (6 cases) and branchial cleft cyst (1 case). The squamous cells in all 5 cases with cytologic findings consistent with branchial cleft cyst were negative for p53 protein; tissue follow-up confirmed the diagnoses of branchial cleft cyst in 4 cases. In the remaining 2 cases excision was not performed, as the cystic lesion was completely decompressed and, clinically, no recurrences were identified at 14 and 8 months of follow-up. Conclusions.—Our findings suggest that p53 immunostaining is helpful in differentiating benign and malignant squamous lesions. While negative staining for p53 does not exclude malignancy, positive immunostaining may aid in accurate fine-needle aspiration diagnosis of malignancy in cytomorphologically equivocal squamous lesions of the neck.

scholarly journals Papillary Thyroid Microcarcinoma with a Large Cystic Dilated Lymph Node Metastasis to the Neck Mimicking a Branchial Cleft Cyst: A Potential Pitfall

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Osman Ilkay Ozdamar ◽  
Gul Ozbilen Acar ◽  
Cigdem Kafkasli ◽  
M. Tayyar Kalcioglu ◽  
Tulay Zenginkinet ◽  
...  
Keyword(s):  
Young Adult ◽  
Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Cystic Mass ◽  
Papillary Thyroid ◽  
Branchial Cleft Cyst ◽  
Fine Needle ◽  
Branchial Cleft

Lateral cervical cystic mass in a young adult very rarely could be a first sign of an occult thyroid papillary microcarcinoma metastasis. In this paper, we presented a 37-year-old male patient whose preoperative 6 cm left lateral cervical cystic mass was initially diagnosed as branchial cleft cyst, but then the postoperative histopathological examination of the mass was revealed as papillary thyroid carcinoma metastasis. Preoperative fine needle aspiration biopsy was relevant with a branchial cleft cyst. In the left thyroid lobe there were 3 solid nodules with 4, 6, and 12 mm dimensions, respectively. One of the nodules had malignant well-differentiated cells diagnosed after fine needle aspiration biopsy. After total thyroidectomy, histopathologic evaluation of biopsy material’s showed papillary thyroid microcarcinomas. This case indicates that especially in a young adult lateral cervical cystic mass should be carefully considered preoperatively for the possibility of metastatic occult thyroid carcinoma, especially for papillary carcinoma in differential diagnosis, and evaluation of the thyroid gland should be taken into account.

Squamous carcinoma arising in a branchial cleft cyst: have you ever treated one? Will you?

2007 ◽  
Vol 122 (6) ◽  
pp. 547-550 ◽  
Author(s):  
K O Devaney ◽  
A Rinaldo ◽  
A Ferlito ◽  
C E Silver ◽  
J J Fagan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Carcinoma ◽  
Primary Site ◽  
Branchial Cleft Cyst ◽  
Cervical Metastases ◽  
Developmental Cyst ◽  
Branchial Cleft ◽  
The Subject

AbstractThe existence of primary branchiogenic carcinoma – that is, carcinoma arising in a pre-existing branchial cleft cyst (a benign developmental cyst) – has in recent decades been the subject of increasing scepticism. Recognition of the propensity of a variety of head and neck sites – including in particular the tonsil – to give rise to cervical metastases while the primary tumours themselves remain undetected has given rise to the idea that virtually all cystic carcinomas of the neck represent metastatic deposits, whether or not their primary sites are found. A diagnosis of primary branchiogenic carcinoma should be viewed with extreme scepticism, and every effort should be made (e.g. imaging, panendoscopy, elective tonsillectomy) to exclude the existence of a primary site elsewhere, before considering a diagnosis of primary branchiogenic carcinoma.

LYMPHOID INFILTRATION IN TOXIC GOITRES STUDIED WITH FINE NEEDLE ASPIRATION BIOPSY

1972 ◽  
Vol 71 (3) ◽  
pp. 480-490 ◽  
Author(s):  
Göran Nilsson
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Lymphoid Cells ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Needle Aspiration Biopsy ◽  
Lymphoid Infiltration ◽  
Long Acting

ABSTRACT Cytodiagnostic fine needle aspiration biopsy specimens from toxic goitres were studied for signs of lymphoid infiltration. Comparison with histological sections of specimens obtained by surgery showed that an excess of lymphoid cells in the aspirate smears corresponded to a large number of lymphoid foci in these sections. Excess of lymphoid cells in the fine needle aspirates was also positively correlated with the occurrence of circulating thyroid antibodies against thyroglobulin and/or cytoplasmic antigen, but not with the presence of the long-acting thyroid stimulating factor, LATS. It also varied with age in that it was most common in the youngest patients and in patients between 40–55 years, while lymphoid infiltration was seldom seen in patients over 55 years. A finding of practical clinical interest was that in toxic goitres with cytological signs of lymphoid infiltration hyperthyroidism had less tendency to recur after treatment with thiocarbamide drugs than in those without such signs.

The value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates (FNA-PTH) for preoperative localization of parathyroid lesions.

2014 ◽  
Author(s):  
Magdalena Kochman ◽  
Waldemar Misiorowski ◽  
Lucyna Papierska ◽  
Elzbieta Stachlewska-Nasfeter ◽  
Witold Chudzinski ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Preoperative Localization ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Parathyroid Lesions

Optimal formalin fixation and processing schedule of cell blocks from fine needle aspirates

Pathology ◽  
1989 ◽  
Vol 21 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Ignatius T.M. Kung ◽  
Rose W.S. Yuen ◽  
John K.C. Chan
Keyword(s):  
Formalin Fixation ◽  
Fine Needle ◽  
Fine Needle Aspirates
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