scholarly journals The effect of colostral immunoglobulin supplement on the passive immunity, growth and health of neonatal calves

1994 ◽  
Vol 3 (5) ◽  
pp. 421-428
Author(s):  
Juha Nousiainen ◽  
Hannu Korhonen ◽  
Eeva-Liisa Syväoja ◽  
Sami Savolainen ◽  
Hannu Saloniemi ◽  
...  
Keyword(s):  
Absorption Rate ◽  
Post Partum ◽  
Live Weight ◽  
Dairy Calves ◽  
Passive Immunity ◽  
Control Group ◽  
Serum Igg ◽  
Neonatal Calves ◽  
Colostrum Feeding

Neonatal dairy calves were randomly allotted to three colostrum feeding regimens with increasing intakes of immunoglobulins (Ig) on the first day of life. The control group was fed one litre of pooled colostrum (Ig intake 19.5 g). In two experimental groups, the pooled colostrum was supplemented with 0.5 or 1.5 litres of commercial Ig-concentrate, giving a total Ig intake of 52.7 and 119.0 g, respectively. Serum IgG, IgM and IgA levels increased linearly (p < 0.001) on day 2 post partum with the increasing Ig intake. The calculated mean Ig-absorption rate was 61% and decreased linearly for IgM (p = 0.051) and IgG (p = 0.078) with increasing Ig intake. At the highest Ig intake, serum IgG remained above 10 g/l during 30 days post partum. In the experimental groups, serum IgM and IgA decreased sharply during the first week of life and were relatively constant thereafter. In the control group, however, there was an increase in serum IgM after one week post partum, perhaps due to the in situ production of Ig. With the increasing Ig intake there was a small and non-significant tendency for better live weight gain (p = 0.286) and a lower incidence of diarrhoea (p = 0.421) during the first four weeks of life. It is concluded that the Ig-product tested is well absorbed during 24 hours post partum and it can be used either as a supplement to maternal colostrum when its quality is poor, or as a substitute when colostrum is not available.

scholarly journals Genome wide association study of passive immunity and disease traits in beef-suckler and dairy calves on Irish farms

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Dayle Johnston ◽  
Robert Mukiibi ◽  
Sinéad M. Waters ◽  
Mark McGee ◽  
Carla Surlis ◽  
...  
Keyword(s):  
Genome Wide Association Study ◽  
Association Studies ◽  
Dairy Calves ◽  
Genome Wide Association ◽  
Passive Immunity ◽  
Genome Wide Association Studies ◽  
Serum Igg ◽  
Genome Wide ◽  
Beef Suckler ◽  
Genome Wide Significance

Abstract Calves with lower concentrations of immunoglobulin G (IgG) in their blood, have a greater risk of developing diseases. There is a lack of knowledge on genetic markers known to be associated with immunological variability or disease resistance. Therefore, the objective of this study was to identify SNP markers associated with passive immunity measures (serum IgG, serum protein, albumin, globulin and total protein concentrations, total solids Brix percentage, zinc sulphate turbidity units) and disease (pneumonia, diarrhoea, crude illness) traits in Irish commercial beef-suckler and dairy calves through genome wide association studies (GWAS). Genotyping was performed on DNA samples from beef-suckler (n = 698) and dairy (n = 1178) calves, using the IDBv3 chip. Heritability of passive immunity associated traits (range 0.02–0.22) and the disease traits (range 0.03–0.20) were low-to-moderate. Twenty-five and fifteen SNPs approached genome wide significance (P < 5 × 10−5) for the passive immunity and the disease traits, respectively. One SNP “ARS-BFGL-BAC-27914” reached Bonferroni genome wide significance (P < 1.15 × 10−6) for an association with serum IgG concentration in beef calves. Further work will evaluate these SNPs in larger cattle populations and assess their contribution to genomic selection breeding strategies, aimed towards producing more disease resistant livestock.

scholarly journals PSVI-21 Evaluation of passive immunity transfer and performance of calves receiving different sources of immunoglobulins

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 431-432
Author(s):  
Cristiane Tomaluski ◽  
Marina Coelho ◽  
Sophia Dondé ◽  
Ariany Toledo ◽  
João Pedro Bernardes ◽  
...  
Keyword(s):  
Block Design ◽  
Passive Immunity ◽  
Total Serum Protein ◽  
Total Serum ◽  
Feeding Period ◽  
Serum Igg ◽  
Randomized Block Design ◽  
Colostrum Feeding ◽  
And Performance ◽  
Milk Feeding

Abstract The efficiency in the passive immunity transfer (PIT) is directly associated with the production cost and productivity of the animals. When fresh maternal colostrum (FC) is not available, frozen colostrum or colostrum replacer (CR) are alternatives to avoid failures in PIT (FPIT). Thirty-nine Holstein calves were used in a randomized block design with gender, weight and date of birth as blocking effect, and distributed in treatments: 1) feeding of 10% BW of CF; 2) feeding of 10% BW of FC; 3) 1.5 dose of a CR (SCCL®, Saskatoon, Canada). Animals received 6L/d of milk until 56d of life when they were subjected to gradual weaning until the end of the study (63d). Feed intake and health was monitored daily, and weight and blood samples were weekly taken. The Brix value at 24h of life was higher in animals receiving maternal colostrum when compared to CR (FC: 9.52a; Frozen: 10.68a; CR: 8.23b; P &lt; 0.01). The immunoglobulins intake was higher (P &lt; 0.01) for calves fed with maternal colostrum (FC or Frozen), which may explain the differences observed in the apparent efficiency of absorption (P = 0.02). The colostrum protocols affected the serum IgG concentration assessed at 24h (FC: 26.65b; Frozen: 35.69a; CR: 16.93c; P &lt; 0.01); however, no treatment resulted in FPIT, with values of serum IgG above 10g/L. Starter intake increased during the milk-feeding period (P &lt; 0.01), with no effects of colostrum feeding. ADG was influenced by treatments (P = 0.01), with higher gains for calves fed FC, resulting in higher final BW (P = 0.04). During the milk-feeding period, plasma glucose and total serum protein were higher for FC than for CR calves, with no differences for calves fed frozen colostrum. Feeding FC resulted in heavier animals at weaning; however, the frozen colostrum and CR used in this study are adequate alternatives, with no FTIP observed.

Predicting colostrum and calf blood components based on refractometry

2021 ◽  
pp. 1-7
Author(s):  
Do T. Hue ◽  
John L. Williams ◽  
Kiro Petrovski ◽  
Cynthia D. K. Bottema
Keyword(s):  
Serum Protein ◽  
Total Protein ◽  
Post Partum ◽  
Calf Serum ◽  
Passive Immunity ◽  
Gamma Glutamyl Transferase ◽  
Fat Percentage ◽  
Serum Igg ◽  
Newborn Calves ◽  
Glutamyl Transferase

Abstract Provision of good quality colostrum is essential for the passive immunity and nutrition of newborn calves. In order to better predict the quality of colostrum and the transfer of passive immunity, the relationships between colostrum components and between calf serum components were examined in this study. Samples of bulk tank milk, colostrum pooled from several cows 0–4 d postpartum, and colostrum collected from individual cows twice daily for 3 d post-partum were compared. With the exception of fat percentage, there were strong correlations between the levels of the components in the pooled colostrum and in the individual cow colostrum collected 0–1 d postpartum. The correlations between total solids as measured by Brix refractometry and total protein, immunoglobulin G (IgG), lactose % and protein % in colostrum within 1 d postpartum and pooled colostrum were 0.92, 0.90, −0.88 and 0.98, respectively. These high correlations enabled these colostrum components to be accurately predicted from Brix % and therefore, the volume of colostrum required to feed neonate calves can be optimised based on Brix refractometry to avoid failure of passive immunity transfer. To assess whether the components obtained from colostrum were correlated in calf blood, newborn calves were separated from their dams before suckling and blood sampled before feeding (day 0), and on days 1 and 7, after receiving colostrum or milk twice a day. The correlations between glucose, total protein, IgG, and gamma-glutamyl transferase (GGT) levels in the calf blood were lower than the correlations observed between the colostrum components. The highest correlation was between serum protein measured by refractometer and serum IgG within one week postpartum. GGT activity was not a good indicator of serum IgG levels. However, serum protein refractometer measurements predicted serum IgG level with high accuracy, providing an on-farm test to determine that calves have received sufficient passive immunity and colostrum components.

scholarly journals Економічна ефективність додаткового введення «Лізину» та «Метіоніну» до ЗНМ за годівлі телят-молочників

2018 ◽  
pp. 99-102
Author(s):  
Г. Л. Лисенко ◽  
К. Д. Бучковська
Keyword(s):  
Economic Efficiency ◽  
Live Weight ◽  
Dairy Calves ◽  
Economic Research ◽  
Milk Replacer ◽  
Control Group ◽  
Group I ◽  
Milk Substitute ◽  
Feed Costs ◽  
The Cost

Вивчено вплив додаткового ведення лізину та метіоніну до ЗНМ на прирости телят-молочників та встановлено економічну ефективність. Дослід проводився на шести групах телят: І група – контроль, яка отримувала основний раціон з вмістом 1,95 г лізину та 0,49 г метіоніну у складі ЗНМ (на 100 г ЗНМ); у ІІ і ІІІ групах вміст лізину становив 2,24 г та 2,44 г відповідно, вміст метіоніну у цих групах не змінювався та становив 0,49 г;  ІV–V групи отримували 0,56 г та 0,61 г метіоніну відповідно, а вміст лізину не змінювався від фактичного (1,95 г); VІ група отримувала одночасно лізин та метіонін, вміст цих амінокислот становив 2,34 г та 0,59 г відповідно. Розрахунок економічної ефективності введення лізину та метіоніну до ЗНМ показав, зростання витрат основних кормів на 1 кг приросту у ІІ, ІІІ, ІV, V групах та зниження у VІ групі. Собівартість 1 кг приросту в II, III, IV та V групах зросла на 12,24, 17,30, 28,15 та 3,86 грн, що у % становило: 18,6, 26,3, 42,8 та 5,9 відповідно, додаткове введення одночасно лізину та метіоніну до ЗНМ у VІ групі знизило собівартість 1 кг приросту на 2,87 грн, що становить 4,4 %. The effect of additional lysine and methionine management on the growth of calves and milk producers has been studied and economic efficiency has been established. The scientific and economic research was conducted at «Druzhba-Nova» ALLC in Chernihiv region. For the experiment, 6 groups of calves were formed at the age of 3 weeks, with 20 heads in each. The groups were selected according to the principle of para-analogues, taking into account the age, gender and live weight of calves. The conditions for keeping calves of the control group and the subjects did not differ. The calves were fed three times a day. During the whole experiment, calves of the control group received the main diet, animals in experimental groups were fed lysine and methionine in the form of powder mass to the milk replace in the morning feeding. Group I – control, receiving the main diet containing 1.95 g of lysine and 0.49 g of methionine in the milk substitute (per 100 g of milk replacer); in the II and III groups, the content of lysine was 2.24 g and 2.44 g, respectively, the content of methionine in these groups did not change and was 0.49 g; IV–V groups received 0.56 g and 0.61 g of methionine, respectively, and the lysine content did not change from the actual one (1.95 g); VІ group received a collection of lysine and methionine, the content of these amino acids amounted to 2.34 g and 0.59 g, respectively. The economic efficiency of the introduction of lysine and methionine into the diet of dairy calves was determined by calculating feed costs by 1 kg of increment and cost of 1 kg of growth. In order to calculate the cost, prices for the first quarter of 2017 were used. It was established that at the additional introduction of lysine and methionine, the cost of 1 kg of growth in the II, III, IV and V groups was increased by 12.24, 17.30, 28.15 and 3.86 UAH, which in % was 18.6, 26.3, 42.8 and 5.9 respectively. However, it should be noted that the additional addition of lysine and methionine to milk replacer cost less than the cost of 1 kg increase of 2.87 UAH, which is 4.4 %.

scholarly journals Salivary IgG levels in neonatal calves and its association to serum IgG: an observational pilot study

2019 ◽  
Vol 3 (1) ◽  
pp. 589-593 ◽  
Author(s):  
Julie Føske Johnsen ◽  
Matteo Chincarini ◽  
Åse Margrethe Sogstad ◽  
Liv Sølverød ◽  
Marie Vatne ◽  
...  
Keyword(s):  
Pilot Study ◽  
Calf Serum ◽  
Passive Transfer ◽  
Dairy Calves ◽  
Strong Positive Correlation ◽  
Adult Cattle ◽  
Future Studies ◽  
Neonatal Calf ◽  
Serum Igg ◽  
Neonatal Calves

Abstract The diagnosis of inadequate transfer of colostrum immunoglobulin G (IgG) to calf serum, often known as failure of passive transfer (&lt;10 g/L IgG1 at 24 to 48 h), necessitates blood sampling from the calf and in some instances the presence of a veterinarian. Sampling saliva is both less invasive and easy for the producer. Previous research has shown that quantification of saliva IgG is possible in juvenile and adult cattle. The objectives of this observational pilot study were to investigate whether IgG can be quantified in neonatal calf saliva, if it is correlated to serum IgG concentrations, and if the indirect quantification of saliva IgG is achievable by use of a digital refractometer. Paired blood and saliva samples were collected from 20 healthy dairy calves aged 1 to 3 d. In these samples, IgG was quantified directly with single radial immunodiffusion and indirectly by use of a digital refractometer indicating Brix % (a subsample of n = 12 saliva samples). A strong positive correlation (r = 0.7, P &lt; 0.001) between saliva IgG (mean ± SD; 0.2 ± 0.11 g/L) and serum IgG (32.1 ± 11.94 g/L) was found. Saliva IgG ranged from the lowest detectable value, 0.1 g/L (n = 6 samples) to 0.6 g/L. Saliva Brix (1.2 ± 0.69%) was not significantly correlated to serum IgG (n = 12, r = 0.43, P = 0.155); however, it was significantly correlated to saliva IgG (n = 12, r = 0.7, P = 0.018) and Brix in serum (n = 12, r = 0.7, P = 0.013). We conclude that IgG was quantifiable in most of the saliva samples. For saliva IgG to be of any value with regards to detecting failure of passive transfer, future studies should investigate methods that can detect IgG &lt;0.1 g/L. The results indicate that saliva IgG can be used to predict serum IgG at levels above 10 g/L, which may warrant further exploration of the use of saliva in the surveillance of failure of passive transfer. The results of the current pilot study did not support the potential usage of a Brix % refractometer to quantify saliva IgG.

scholarly journals The effect of a Forest Biomass Supplement on Morphophysiological Parameters of Calves

2021 ◽  
Vol 34 (2) ◽  
pp. 184-192
Author(s):  
Vladimir V. Zaitsev ◽  
Ivan N. Mayorov ◽  
Lilia M. Zaitseva ◽  
Vasily P. Korotky ◽  
Viktor A. Ryzhov ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Forest Biomass ◽  
Live Weight ◽  
Blood Analysis ◽  
Dairy Calves ◽  
Natural Resistance ◽  
Control Group ◽  
Black And White ◽  
Whole Milk ◽  
Positive Effect

Breeding, preserving, and successfully rearing young animals resistant to various environmental influences is one of the main parameters of effective livestock management. The study aimed to study the indicators of natural resistance and the growth rate of calves under the influence of dietary supplements. The studies were carried out on four groups of black-and-white calves, 10 heads each, at the age of 2-5 months. The dairy calves of the control group were fed according to the ration adopted on the farm (basic ration, including cereal-legume hay, whole milk, milk replacer, concentrates, chalk, salt). In addition to the main diet, the animals of the experimental groups were given a dietary supplement. At 2-3, 3-4, and 4-5, months of age, calves were given 12-23, 19-38, and 23-47  g.head-1 of dietary supplement per day, respectively. The article deals with the effect of a forest biomass supplement on the morphophysiological parameters of calves. Biochemical blood analysis and the features of metabolic processes in the bodies of animals are studied. The results indicated that the use of a dietary supplement at a dosage of 30 g/head of cattle per day contributes to the highest increase (9.9%) in live weight gain of experimental animals and an improvement in natural resistance parameters (bactericidal activity of blood serum, phagocytic activity of neutrophils). Based on the data of biochemical and haematological blood tests, the authors conclude that the inclusion of a dietary supplement in the diet of calves has a positive effect on the indices of natural resistance and the course of nitrogen metabolism.

scholarly journals Maternal influences on oral and faecal microbiota maturation in neonatal calves in beef and dairy production systems

2020 ◽  
Author(s):  
Matthew Barden ◽  
Peter Richards-Rios ◽  
Erika Ganda ◽  
Luca Lenzi ◽  
Richard Eccles ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Post Partum ◽  
Farming System ◽  
Dairy Calves ◽  
Rrna Gene ◽  
Oral Microbiota ◽  
Faecal Microbiota ◽  
Gastrointestinal Microbiota ◽  
Early Maturation ◽  
Neonatal Calves

Abstract Background: The gastrointestinal microbiota of neonatal calves changes rapidly during the first weeks of life. The dam is considered an important source of microbes for the calf; consequently, the development of calf microbiota may vary with farming system due to differences between the contact the calf has with the dam. The objective of this study was to characterise the early maturation of oral and faecal microbiota in beef and dairy calves using high-throughput sequencing of the 16S rRNA gene. The microbiota of calves was compared to selected anatomical niches on their dams which were likely to contribute to the vertical transfer of microbes. Results: A total of 14,125 amplicon sequence variants (ASVs) were identified and taxonomically assigned. The oral microbiota of calves and their dams became more similar over the first four weeks of life. The faecal microbiota of four-week old calves was most similar to the oral microbiota of calves and adult cows but there was little similarity between the faecal microbiota of calves and cows. ASVs were identified in the oral microbiota of four-week old calves that were also at present cow niches at calving. Very few ASVs were present in the calf faecal microbiota at four-weeks of age that were present in any adult cow niche at calving. These results were observed in both beef and dairy calves. Conclusions: We did not observe any marked differences in the maturation of the oral and faecal microbiota between beef or dairy calves, despite dairy calves having very limited contact with their dam. This suggests the development of gastrointestinal microbiota in calves is not affected by continued vertical transmission of microbes from the dam. The oral microbiota of calves matured more quickly than the faecal microbiota and by four-weeks of age it was similar to the oral microbiota of adult cows. Although the calf faecal microbiota changed over the first four-weeks of life, it bore little resemblance to the faeces of adult cows. Any maternal influence on these changes presumably occurred immediately post-partum as there were few differences between the trends observed in beef and dairy calves.

Determination of neonatal serum immunoglobulin G concentrations associated with mortality during the first 4 months of life in dairy heifer calves

2015 ◽  
Vol 82 (4) ◽  
pp. 400-406 ◽  
Author(s):  
Munashe Chigerwe ◽  
Jill V Hagey ◽  
Sharif S Aly
Keyword(s):  
Immunoglobulin G ◽  
Dairy Farms ◽  
Dairy Calves ◽  
Serum Immunoglobulin ◽  
Passive Immunity ◽  
Likelihood Ratios ◽  
Probability Of Survival ◽  
Serum Igg ◽  
Dairy Heifer

Colostral administration practices on dairy farms have significantly improved over the last 15–20 years resulting in prevalence of calves ingesting insufficient colostrum decreasing from 35–40% to 19%. Despite these improvements, the serum immunoglobulin G (IgG) concentration of ≥1000 g/dl and serum total protein (TP) concentrations of ≥5·2 g/dl are considered indicative of adequate transfer of immunity. We hypothesised that the current serum IgG concentrations of ≥1000 mg/dl is too low to indicate adequate transfer of colostral immunity on modern dairies. The objective of this study was to determine the serum IgG and TP concentrations indicating adequate transfer of passive immunity in dairy heifer calves. A cohort study of 1290 heifers from a calf raising facility for 48 dairy farms was performed. Heifers were assigned into strata based on serum IgG and TP concentrations. Mortality events were recorded for the heifers for 4 months. Interval likelihood ratios for mortality were calculated for heifers in each stratum of serum IgG or TP concentrations. Logistic regression to predict probability of mortality events was performed. Estimates of probability of survival were evaluated using survival analysis. Serum strata of ≤1500, 1501–2000 or >2500 were not significant predictors of mortality during the 120 d of rearing. Serum IgG concentration was not a significant predictor of hazard for mortality. In contrast to previous studies, serum IgG and TP concentrations of 2001–2500 mg/dl and 5·8–6·3 g/dl respectively, were considered optimum for indicating adequate passive transfer of colostral immunity in dairy calves based on the likelihood ratios. On dairies with optimum colostral feeding practices, serum IgG and TP concentrations of 2001–2500 mg/dl and 5·8–6·3 g/dl are recommended as endpoints to indicate adequate passive immunity in dairy calves.

scholarly journals 451 Late-Breaking: Saccharomyces cerevisiae boulardii stimulates immunoglobulin A production in the gut of neonate dairy calves

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 143-143
Author(s):  
Clothilde Villot ◽  
Leluo Guan ◽  
Andrew Skidmore ◽  
Eric Chevaux ◽  
Michael A Steele
Keyword(s):  
Immunoglobulin A ◽  
Treated Group ◽  
Dairy Calves ◽  
Control Group ◽  
Gene Expressions ◽  
Bull Calves ◽  
Rapid Changes ◽  
Neonatal Calves ◽  
Iga Production ◽  
Stimulation Of

Abstract Calves are born with a naïve immune system at birth and undergo rapid changes in terms of immunity. This study focused on evaluating the effect of S. boulardii CNCMI-1079 (SCB) supplementation from birth on immunoglobulin A (IgA) production in the gut of neonate dairy calves. Holstein bull calves (n = 20) were delivered naturally and immediately removed from the dam, and housed in individual straw-bedded pens with a random assignment to a treated group (supplementation with SCB: 10 × 109 CFU/d in each morning meal) or a control group (no supplementation). All the calves received two first meals of a standardized colostrum at 2 h and 12 h after birth followed by two meals per day of milk replacer (7.5% of birth BW; 260 g/kg CP; 160 g/kg crude fat, at 150g/L). Calves were euthanized at 7 d of age and samples from jejunum, ileum and colon were collected. The concentration of IgA and the gene expressions of polymeric Ig receptor (pIgR) and a receptor of plasma B cells (CD79α) were compared between the two groups and among the locations. The expression of CD79α was up-regulated in the ileum compared to jejunum and colon tissues (P &lt; 0.01), whereas pIgR down-regulated in the ileum compared to jejunum and colon (P &lt; 0.01). The supplementation of SCB increased the IgA concentration in the ileum and colon of treated calves compared to the control calves (respectively 1.98 ± 0.09 vs 1.18 ± 0.15 mg/g DM of ileum content, and 1.45 ± 0.14 vs 0.59 ± 0.06 mg/g DM of colon content, P &lt; 0.001). The results suggest that one of the mechanisms by which SCB exerts an immunoprotective effect in the gut is by stimulation of IgA’s secretion which may play a major role in mucosal protection in neonatal calves.

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

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