Neuro-AIDS: Current status and Challenges to Antiretroviral Drug Therapy (ART) for Its Treatment.

2020 ◽  
Vol 15 ◽  
Author(s):  
Smita P. Kakad ◽  
Sanjay J. Kshirsagar
Keyword(s):  
Nervous System ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Sensory Neuropathy ◽  
Current Status ◽  
Viral Reservoir ◽  
Viral Reservoirs ◽  
Highly Active ◽  
Aids Therapy ◽  
The Brain

Introduction: The infiltration of HIV into the brain alters the functions of the nervous system known as NeuroAIDS. It leads to neuronal defects clinically manifested by motor and cognitive dysfunctions. Materials/Methods: Current antiretroviral therapy can prevent viral replication but cannot cure the disease completely. HAART-Highly active antiretroviral therapy used for the treatment of HIV infection. Challenges in neuro-AIDS therapy are as shown in the graphical abstract. One of the challenges is latent viral reservoirs like the brain; which acts as a sanctuary site for viruses. Nearly ~50% of HIV patients show neuropathological signs. Nervous system related disorders including AIDS dementia, sensory neuropathy, and myelopathy have a 25% of prevalence in patients having access to a highly active combination antiretroviral therapy. Results/Conclusions: Brain is one of the viral sanctuary sites for HIV. The current need of neuro-AIDS therapy is to target the brain as a viral reservoir. Drugs should cross or bypass the blood-brain barrier to reach the brain with effective concentrations. Current research on novel drug delivery approaches may prove helpful to treat neuro-AIDS and related disorders effectively.

IMPROVING EIGENSPACE-BASED FUZZY LOGIC SYSTEM USING A LINEAR INTERPOLATION SCHEME FOR SPEECH PATTERN RECOGNITION

2013 ◽  
Vol 37 (3) ◽  
pp. 611-620
Author(s):  
Ing-Jr Ding ◽  
Chih-Ta Yen
Keyword(s):  
Pattern Recognition ◽  
Fuzzy Logic ◽  
Recognition Performance ◽  
Linear Interpolation ◽  
Fuzzy Logic System ◽  
Interpolation Scheme ◽  
Speech Pattern ◽  
Eigen Value ◽  
Target Speaker ◽  
Logic System

The Eigen-FLS approach using an eigenspace-based scheme for fast fuzzy logic system (FLS) establishments has been attempted successfully in speech pattern recognition. However, speech pattern recognition by Eigen-FLS will still encounter a dissatisfactory recognition performance when the collected data for eigen value calculations of the FLS eigenspace is scarce. To tackle this issue, this paper proposes two improved-versioned Eigen-FLS methods, incremental MLED Eigen-FLS and EigenMLLR-like Eigen-FLS, both of which use a linear interpolation scheme for properly adjusting the target speaker’s Eigen-FLS model derived from an FLS eigenspace. Developed incremental MLED Eigen-FLS and EigenMLLR-like Eigen-FLS are superior to conventional Eigen-FLS especially in the situation of insufficient data from the target speaker.

scholarly journals LI Detector: a framework for sensitive colony-based screens regardless of the distribution of fitness effects

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Saurin Bipin Parikh ◽  
Nelson Castilho Coelho ◽  
Anne-Ruxandra Carvunis
Keyword(s):  
Linear Interpolation ◽  
Colony Growth ◽  
Relative Fitness ◽  
Environment Interaction ◽  
Nutrient Distribution ◽  
Underlying Distribution ◽  
Fitness Effects ◽  
Fitness Value ◽  
Genetic Perturbations ◽  
Surface Irregularities

Abstract Microbial growth characteristics have long been used to investigate fundamental questions of biology. Colony-based high-throughput screens enable parallel fitness estimation of thousands of individual strains using colony growth as a proxy for fitness. However, fitness estimation is complicated by spatial biases affecting colony growth, including uneven nutrient distribution, agar surface irregularities, and batch effects. Analytical methods that have been developed to correct for these spatial biases rely on the following assumptions: (1) that fitness effects are normally distributed, and (2) that most genetic perturbations lead to minor changes in fitness. Although reasonable for many applications, these assumptions are not always warranted and can limit the ability to detect small fitness effects. Beneficial fitness effects, in particular, are notoriously difficult to detect under these assumptions. Here, we developed the linear interpolation-based detector (LI Detector) framework to enable sensitive colony-based screening without making prior assumptions about the underlying distribution of fitness effects. The LI Detector uses a grid of reference colonies to assign a relative fitness value to every colony on the plate. We show that the LI Detector is effective in correcting for spatial biases and equally sensitive toward increase and decrease in fitness. LI Detector offers a tunable system that allows the user to identify small fitness effects with unprecedented sensitivity and specificity. LI Detector can be utilized to develop and refine gene–gene and gene–environment interaction networks of colony-forming organisms, including yeast, by increasing the range of fitness effects that can be reliably detected.

scholarly journals THU0617-HPR TOWARDS A UNIVERSAL DEFINITION OF DISEASE ACTIVITY SCORES THRESHOLDS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 551.1-551
Author(s):  
N. Foulquier ◽  
B. Chevet ◽  
G. Carvajal Alegria ◽  
L. Saraux ◽  
V. Devauchelle-Pensec ◽  
...  
Keyword(s):  
Literature Review ◽  
Disease Activity ◽  
Mobile Application ◽  
Inflammatory Diseases ◽  
Smart Phone ◽  
Linear Interpolation ◽  
Publication Date ◽  
Cutaneous Manifestations ◽  
Manual Search ◽  
Universal Definition

Background:For rheumatologists monitoring patients with various diseases and dealing with multiple scores with different maximum values (9 for RA-DAS, 6.4 for AS-DAS and 60 for PMR-AS) and values thresholds to characterize the different levels of disease activity (low, intermediate and high) can be a tedious task. The same problematic could arise in other specialty than rheumatology. Normalization of these scores seems to be necessary to facilitate daily clinical practice (1).Objectives:To indentify and standardize scores of activity of inflammatory diseases.Methods:We conducted a literature review on activity criteria using both a manual approach and the BIBOT software (2) published in English between 1.1.1975 and 31.12.2018. Within all extracted disease activity scores, we selected those with cut off values in four classes (remission, low, moderate and high disease activity). We used a linear interpolation to map all these disease activity scores to our new score, the AS-135, and developed a smart-phone application to perform the conversion automatically.Results:1068 articles were analyzed by BIBOT, 86 were excluded on the basis of the language used for their writing and 11 were excluded on the basis of their publication date. 599 were selected based on their titles, abstracts and keywords. 108 activity criteria from various fields (rheumatology, dermatology, gastroenterology, psychiatry, neurology and pneumology) were identified, but it is in rheumatology that we find separation into four classes. 10 scores met our inclusion criteria and were implemented in the Android app. These are: DAS28 (ESR), DAS28 (CRP), SDAI, ASDAS (ESR), ASDAS (CRP), ESSDAI, SLEDAI-2K, DAPSA, PMR-AS (ESR) and PMR-AS (CRP). We built the AS135 score modification for each selected score using a linear interpolation of the existing criteria. It was defined on the interval [0,10] and values 1, 3 and 5 were used as thresholds. These arbitrary thresholds are then associated with the thresholds of the existing criteria and an interpolation can be calculated, allowing the conversion of the existing criteria into AS135 criterion. We have finally created a mobile application that allows each user to obtain both the original value of the activity criterion.Conclusion:We have created a mobile application that allows any user to obtain in a simple way the level of disease activity, whatever the criterion used to describe it, since the application returns, in addition to the value of the activity criterion calculated from data returned by the physician, the transformation of this value into AS135 criterion and its interpretation in terms of level of activity of the pathology. The application is now available for Android devices and we plan to start developing a version for iOS devices.References:[1]Saraux L, Devauchelle-Pensec V, Saraux A. Plea for standardization of disease activity scores. Rheumatol Oxf Engl. 2019 Aug 1;58(8):1500–1[2]Orgeolet L, Foulquier N, Misery L, Redou P, Pers J-O, Devauchelle-Pensec V, et al. Can artificial intelligence replace manual search for systematic literature? Review on cutaneous manifestations in primary Sjögren’s syndrome. Rheumatol Oxf Engl. 2019 Aug 31;Disclosure of Interests:None declared

scholarly journals MorphOT: transport-based interpolation between EM maps with UCSF ChimeraX

2020 ◽  
Author(s):  
Arthur Ecoffet ◽  
Frédéric Poitevin ◽  
Khanh Dao Duc
Keyword(s):  
Optimal Transport ◽  
Three Dimensional ◽  
Linear Interpolation ◽  
The Other ◽  
Supplementary Information ◽  
Conformational Heterogeneity ◽  
Supplementary Data ◽  
Image Dataset ◽  
Standard Linear ◽  
Unique Potential

Abstract Motivation Cryogenic electron microscopy (cryo-EM) offers the unique potential to capture conformational heterogeneity, by solving multiple three-dimensional classes that co-exist within a single cryo-EM image dataset. To investigate the extent and implications of such heterogeneity, we propose to use an optimal-transport-based metric to interpolate barycenters between EM maps and produce morphing trajectories. Results While standard linear interpolation mostly fails to produce realistic transitions, our method yields continuous trajectories that displace densities to morph one map into the other, instead of blending them. Availability and implementation Our method is implemented as a plug-in for ChimeraX called MorphOT, which allows the use of both CPU or GPU resources. The code is publicly available on GitHub (https://github.com/kdd-ubc/MorphOT.git), with documentation containing tutorial and datasets. Supplementary information Supplementary data are available at Bioinformatics online.

An experimental study on optimal spark timing control for improved performance of a flex fuel vehicle engine

2019 ◽  
Vol 234 (5) ◽  
pp. 1294-1303
Author(s):  
Junsang Yoo ◽  
Taeyong Lee ◽  
Pyungsik Go ◽  
Yongseok Cho ◽  
Kwangsoon Choi ◽  
...  
Keyword(s):  
Empirical Equation ◽  
Interpolation Method ◽  
Linear Interpolation ◽  
Combustion Characteristics ◽  
Combustion Stability ◽  
Timing Control ◽  
Vehicle Engine ◽  
Spark Timing ◽  
Linear Interpolation Method ◽  
Blended Fuels

In the American continent, the most frequently used alternative fuel is ethanol. Especially in Brazil, various blends of gasoline–ethanol fuels are widely spread. The vehicle using blended fuel is called flexible fuel vehicle. Because of several selections for the blending ratios in gas stations, the fuel properties may vary after refueling depending on a driver’s selection. Also, the combustion characteristics of the flexible fuel vehicle engine may change. In order to respond to the flexible fuel vehicle market in Brazil, a study on blended fuels is performed. The main purpose of this study is to enhance performance of the flexible fuel vehicle engine to target Brazilian market. Therefore, we investigated combustion characteristics and optimal spark timings of the blended fuels with various blending ratios to improve the performance of the flexible fuel vehicle engine. As a tool for prediction of the optimal spark timing for the 1.6L flexible fuel vehicle engine, the empirical equation was suggested. The validity of the equation was investigated by comparing the predicted optimal spark timings with the stock spark timings through engine tests. When the stock spark timings of E0 and E100 were optimal, the empirical equation predicted the actual optimal spark timings for blended fuels with a good accuracy. In all conditions, by optimizing spark timing control, performance was improved. Especially, torque improvements of E30 and E50 fuels were 5.4% and 1.8%, respectively, without affecting combustion stability. From these results, it was concluded that the linear interpolation method is not suitable for flexible fuel vehicle engine control. Instead of linear interpolation method, optimal spark timing which reflects specific octane numbers of gasoline–ethanol blended fuels should be applied to maximize performance of the flexible fuel vehicle engine. The results of this study are expected to save the effort required for engine calibration when developing new flexible fuel vehicle engines and to be used as a basic strategy to improve the performance of other flexible fuel vehicle engines.

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