scholarly journals Articular manifestations in acromegaly: diagnostic and therapeutic implications of the coexistence of acromegalic arthropathy and rheumatoid arthritis

2021 ◽  
Author(s):  
G. Horta-Baas
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Implications ◽  
Acromegalic Arthropathy

Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications

Toxicology ◽  
2021 ◽  
Vol 461 ◽  
pp. 152909
Author(s):  
Ramkumar Katturajan ◽  
Vijayalakshmi S ◽  
Mahabookhan Rasool ◽  
Sabina Evan Prince
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Implications ◽  
Rheumatoid Arthritis Treatment ◽  
Molecular Toxicity

scholarly journals Metabolic Syndrome in Rheumatoid Arthritis

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Iván Ferraz-Amaro ◽  
Carlos González-Juanatey ◽  
Raquel López-Mejias ◽  
Leyre Riancho-Zarrabeitia ◽  
Miguel A. González-Gay
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chronic Conditions ◽  
Essential Feature ◽  
Unanswered Question ◽  
Biologic Therapies ◽  
Therapeutic Implications ◽  
Beneficial Effects ◽  
The Metabolic Syndrome

Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic conditions including obesity, diabetes mellitus, atherosclerosis, and RA. Adipokines may play a role in the development of atherogenesis in patients with RA. Biologic therapies, such as TNF-αantagonists, that block proinflammatory cytokines have beneficial effects on the insulin resistance that is often observed in patients with RA.

scholarly journals Efficient Treatment of Rheumatoid Arthritis by Degradable LPCE Nano-Conjugate-Delivered p65 siRNA

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 162
Author(s):  
Xiaohua Chen ◽  
Bailing Zhou ◽  
Yan Gao ◽  
Kaiyu Wang ◽  
Jieping Wu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
High Efficiency ◽  
Cartilage Damage ◽  
Efficient Treatment ◽  
New Approach ◽  
Therapeutic Implications ◽  
Interfering Rna ◽  
Light Chain Enhancer ◽  
Made In

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide, causing severe cartilage damage and disability. Despite the recent progress made in RA treatment, limitations remain in achieving early and efficient therapeutic intervention. Advanced therapeutic strategies are in high demand, and siRNA-based therapeutic technology with a gene-silencing ability represents a new approach for RA treatment. In this study, we created a cationic delivery micelle consisting of low-molecular-weight (LMW) polyethylenimine (PEI)–cholesterol–polyethylene glycol (PEG) (LPCE) for small interfering RNA (siRNA)-based RA gene therapy. The carrier is based on LMW PEI and modified with cholesterol and PEG. With these two modifications, the LPCE micelle becomes multifunctional, and it efficiently delivered siRNA to macrophages with a high efficiency greater than 70%. The synthesized LPCE exhibits strong siRNA protection ability and high safety. By delivering nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 siRNA, the p65 siRNA/LPCE complex efficiently inhibited macrophage-based cytokine release in vitro. Local administration of the p65 siRNA/LPCE complex exhibited a fast and potent anti-inflammatory effect against RA in a mouse model. According to the results of this study, the functionalized LPCE micelle that we prepared has potential gene therapeutic implications for RA.

scholarly journals Therapeutic implications of autoantibodies in rheumatoid arthritis

RMD Open ◽  
2016 ◽  
Vol 2 (1) ◽  
pp. e000009 ◽  
Author(s):  
Daniel Aletaha ◽  
Stephan Blüml
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Implications

The endocannabinoid system and its therapeutic implications in rheumatoid arthritis

2015 ◽  
Vol 26 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Huan Gui ◽  
Qiang Tong ◽  
Wenchun Qu ◽  
Chen-Mei Mao ◽  
Sheng-Ming Dai
Keyword(s):  
Rheumatoid Arthritis ◽  
Endocannabinoid System ◽  
Therapeutic Implications

scholarly journals Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Alessia Alunno ◽  
Mirko Manetti ◽  
Sara Caterbi ◽  
Lidia Ibba-Manneschi ◽  
Onelia Bistoni ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Th17 Cells ◽  
Current Knowledge ◽  
Cell Subset ◽  
Treg Cells ◽  
Lymphocyte Subpopulations ◽  
Therapeutic Targeting ◽  
Therapeutic Implications ◽  
T Lymphocyte Subpopulations

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA. In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated. This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder.

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