scholarly journals Cutaneous leiomyomas: a clinicpathological and epidemiological review

2021 ◽  
Author(s):  
A.D. Agulló Pérez ◽  
M.A. Resano Abárzuza ◽  
A. Córdoba Iturriagagoitia ◽  
G. Aisa Rivera ◽  
A. Patiño García ◽  
...  
Keyword(s):  
Cutaneous Leiomyomas

A Case of Multiple Cutaneous Leiomyomas with Uterine Myomas

2016 ◽  
Vol 78 (1) ◽  
pp. 36-39
Author(s):  
Keiko SAKAMOTO ◽  
Miki KOHNO ◽  
Akari SHIGYO ◽  
Masutaka FURUE
Keyword(s):  
Uterine Myomas ◽  
Cutaneous Leiomyomas

Familial Multiple Cutaneous Leiomyomas

Dermatology ◽  
1995 ◽  
Vol 191 (4) ◽  
pp. 295-298 ◽  
Author(s):  
M.A. Fernández-Pugnaire ◽  
V. Delgado-Florencio
Keyword(s):  
Cutaneous Leiomyomas

scholarly journals A Case of Reed Syndrome with a Novel Mutation in the Fumarate Hydratase Gene

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Christin B. Laufer ◽  
Layne B. Green ◽  
Darren E. Whittemore
Keyword(s):  
Novel Mutation ◽  
Fumarate Hydratase ◽  
Uterine Fibroids ◽  
Papillary Renal Cell Carcinoma ◽  
Young Female ◽  
Cancer Predisposition Syndrome ◽  
Dermatology Clinic ◽  
Underlying Malignancy ◽  
History Of ◽  
Cutaneous Leiomyomas

Reed syndrome is a heritable cancer predisposition syndrome that can easily be missed due to its simple presentation of tender red papules. We present a young female with a history of uterine fibroids who presented to the dermatology clinic with several painful pink papules that had been previously evaluated by multiple physicians. Biopsy results were diagnostic for cutaneous leiomyomas, raising clinical suspicion for Reed syndrome. She was found to have a novel heterozygote mutation in her fumarate hydratase gene, supporting the diagnosis. This case demonstrates the importance of rendering a proper workup for seemingly innocent skin complaints as they could be associated with an underlying malignancy. Despite the fact that up to 16% of patients can develop aggressive type 2 papillary renal cell carcinoma, there are currently no consensus guidelines on screening or patient management.

scholarly journals Rare Leiomyoma of the Tunica Dartos: A Case Report with Clinical Relevance for Malignant Transformation and HLRCC

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Robert C. Bell ◽  
Evan T. Austin ◽  
Stacy J. Arnold ◽  
Frank C. Lin ◽  
Jonathan R. Walker ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Renal Cell ◽  
Cell Cancer ◽  
Surgical Excision ◽  
High Rate ◽  
Case Presentation ◽  
Increased Risk ◽  
The Right ◽  
Cutaneous Leiomyomas

Background. Genital leiomyomas fall under the broader category of cutaneous leiomyomas, which are rare smooth muscle neoplasms accounting for 5% of all leiomyomas. Genital leiomyomas arising from the dartos muscle are exceedingly rare with fewer than 30 cases reported in the literature. They are typically benign and adequately treated with simple surgical excision; however, previously reported cases of malignant transformation and a possible link to the hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome warrant closer follow-up.Case Presentation. We report a case of a 47-year-old male refugee from Rwanda found to have a mobile, pea-sized, mildly painful scrotal lesion near the left penoscrotal junction and 1.5 cm indeterminate vascular mass in the right kidney. Surgical excision of the scrotal nodule was performed and the diagnosis of a dartoic leiomyoma was rendered. The presence of moderate nuclear atypia, rare mitotic activity, and close surgical margins prompted a wide reexcision. We report the surgical approach, pathologic findings, and clinical follow-up related to this scrotal lesion.Conclusion. Scrotal leiomyomas demonstrate a high rate of recurrence and pose a risk for malignant transformation. They may also indicate an underlying autosomal dominant syndrome associated with increased risk for development of an aggressive form of renal cell carcinoma. When discovered, management should include surgical excision, screening for syndromic features, and routine follow-up.

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