Ensemble Model Predictive Control Strategies Can Reduce Exercise Hypoglycemia in Type 1 Diabetes: In Silico Studies

2019 ◽  
Author(s):  
Jose Garcia-Tirado ◽  
Patricio Colmegna ◽  
John Corbett ◽  
Basak Ozaslan ◽  
Marc D. Breton
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
In Silico ◽  
Control Strategies ◽  
Ensemble Model ◽  
In Silico Studies

scholarly journals Closed-loop control with unannounced exercise for adults with type 1 diabetes using the Ensemble Model Predictive Control

2019 ◽  
Vol 80 ◽  
pp. 202-210 ◽  
Author(s):  
Jose Garcia-Tirado ◽  
John P. Corbett ◽  
Dimitri Boiroux ◽  
John Bagterp Jørgensen ◽  
Marc D. Breton
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Ensemble Model ◽  
Loop Control

scholarly journals Run-to-Run Tuning of Model Predictive Control for Type 1 Diabetes Subjects: In Silico Trial

2009 ◽  
Vol 3 (5) ◽  
pp. 1091-1098 ◽  
Author(s):  
Lalo Magni ◽  
Marco Forgione ◽  
Chiara Toffanin ◽  
Chiara Dalla Man ◽  
Boris Kovatchev ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Model Predictive Control ◽  
Predictive Control ◽  
In Silico ◽  
Insulin Pump ◽  
Artificial Pancreas ◽  
Arx Model ◽  
Starting Point

Background: The technological advancements in subcutaneous continuous glucose monitoring and insulin pump delivery systems have paved the way to clinical testing of artificial pancreas devices. The experience derived by clinical trials poses technological challenges to the automatic control expert, the most notable being the large interpatient and intrapatient variability and the inherent uncertainty of patient information. Methods: A new model predictive control (MPC) glucose control system is proposed. The starting point is an MPC algorithm applied in 20 type 1 diabetes mellitus (T1DM) subjects. Three main changes are introduced: individualization of the ARX model used for prediction; synthesis of the MPC law on top of the open-loop basal/bolus therapy; and a run-to-run approach for implementing day-by-day tuning of the algorithm. In order to individualize the ARX model, a sufficiently exciting insulin profile is imposed by splitting the premeal bolus into two smaller boluses (40% and 60%) injected 30 min before and 30 min after the meal. Results: The proposed algorithm was tested on 100 virtual subjects extracted from an in silico T1DM population. The trial simulates 44 consecutive days, during which the patient receives breakfast, lunch, and dinner each day. For 10 days, meals are multiplied by a random variable uniformly distributed in [0.5, 1.5], while insulin delivery is based on nominal meals. Moreover, for 10 days, either a linear increase or decrease of insulin sensitivity (±25% of nominal value) is introduced. Conclusions: The ARX model identification procedure offers an automatic tool for patient model individualization. The run-to-run approach is an effective way to auto-tune the aggressiveness of the closed-loop control law, is robust to meal variation, and is also capable of adapting the regulator to slow parameter variations, e.g., on insulin sensitivity.

Model Predictive Control of glucose concentration in subjects with type 1 diabetes: an in silico trial

2008 ◽  
Vol 41 (2) ◽  
pp. 4246-4251 ◽  
Author(s):  
L. Magni ◽  
D.M. Raimondo ◽  
C. Dalla Man ◽  
G. De Nicolao ◽  
B. Kovatchev ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Glucose Concentration ◽  
In Silico

scholarly journals Model Predictive Control of Type 1 Diabetes: An in Silico Trial

2007 ◽  
Vol 1 (6) ◽  
pp. 804-812 ◽  
Author(s):  
Lalo Magni ◽  
Davide M. Raimondo ◽  
Luca Bossi ◽  
Chiara Dalla Man ◽  
Giuseppe De Nicolao ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
In Silico

Meal Estimation in Nonlinear Model Predictive Control for Type 1 Diabetes

2010 ◽  
Vol 43 (14) ◽  
pp. 1052-1057 ◽  
Author(s):  
Dimitri Boiroux ◽  
Daniel A. Finan ◽  
John Bagterp Jørgensen ◽  
Niels Kjølstad Poulsen ◽  
Henrik Madsen
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Nonlinear Model ◽  
Nonlinear Model Predictive Control

scholarly journals Performance of the Omnipod Personalized Model Predictive Control Algorithm with Meal Bolus Challenges in Adults with Type 1 Diabetes

2018 ◽  
Vol 20 (9) ◽  
pp. 585-595 ◽  
Author(s):  
Bruce A. Buckingham ◽  
Mark P. Christiansen ◽  
Gregory P. Forlenza ◽  
R. Paul Wadwa ◽  
Thomas A. Peyser ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Control Algorithm ◽  
Model Predictive Control Algorithm
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