TAY-SACHS DISEASE: DIAGNOSTIC, MODELING AND TREATMENT APPROACHES

2020 ◽  
Vol XV (1) ◽  
Author(s):  
V. Solovyeva ◽  
A. Shaimardanova ◽  
D. Chulpanova ◽  
K. Kitaeva ◽  
A. Rizvanov
Keyword(s):  
Treatment Approaches ◽  
Tay Sachs Disease ◽  
Diagnostic Modeling

Cytoplasmic Granules in Lymphocytes from Rats Dosed with SK&F 14336-D

1971 ◽  
Vol 29 ◽  
pp. 556-557
Author(s):  
T. G. Merrill ◽  
B. J. Payne ◽  
A. J. Tousimis
Keyword(s):  
Lipid Storage ◽  
Pokeweed Mitogen ◽  
Electron Microscopic ◽  
Cytoplasmic Granules ◽  
Storage Diseases ◽  
Tay Sachs Disease ◽  
Large Numbers ◽  
Microscopic Studies ◽  
Neurovisceral Lipidosis

Rats given SK&F 14336-D (9-[3-Dimethylamino propyl]-2-chloroacridane), a tranquilizing drug, developed an increased number of vacuolated lymphocytes as observed by light microscopy. Vacuoles in peripheral blood of rats and humans apparently are rare and are not usually reported in differential counts. Transforming agents such as phytohemagglutinin and pokeweed mitogen induce similar vacuoles in in vitro cultures of lymphocytes. These vacuoles have also been reported in some of the lipid-storage diseases of humans such as amaurotic familial idiocy, familial neurovisceral lipidosis, lipomucopolysaccharidosis and sphingomyelinosis. Electron microscopic studies of Tay-Sachs' disease and of chloroquine treated swine have demonstrated large numbers of “membranous cytoplasmic granules” in the cytoplasm of neurons, in addition to lymphocytes. The present study was undertaken with the purpose of characterizing the membranous inclusions and developing an experimental animal model which may be used for the study of lipid storage diseases.

New treatment approaches for lung cancer and impact on survival

2002 ◽  
Vol 29 (3 Suppl 8) ◽  
pp. 26-29 ◽  
Author(s):  
Hern[aacute]n Cort[eacute]s-Funes
Keyword(s):  
Lung Cancer ◽  
Treatment Approaches ◽  
Impact On Survival ◽  
New Treatment

Treatment approaches to complicated sternal wounds – a therapeutic algorithm

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
I Ennker ◽  
M Suprunov ◽  
B Kojcici ◽  
T Chaves ◽  
PM Vogt ◽  
...  
Keyword(s):  
Treatment Approaches ◽  
Therapeutic Algorithm
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