scholarly journals CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

2010 ◽  
Vol 177 (5) ◽  
pp. 2549-2562 ◽  
Author(s):  
Sungho Lee ◽  
Nicholas H. Varvel ◽  
Megan E. Konerth ◽  
Guixiang Xu ◽  
Astrid E. Cardona ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Microglial Activation ◽  
Beta Amyloid ◽  
Amyloid Deposition

scholarly journals Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 870 ◽  
Author(s):  
Raluca Stefanescu ◽  
Gabriela Dumitriṭa Stanciu ◽  
Andrei Luca ◽  
Luminita Paduraru ◽  
Bogdan-Ionel Tamba
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Metabolites ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Beta Amyloid ◽  
Thioflavin T ◽  
Amyloid Angiopathy ◽  
Transgenic Mouse Models ◽  
Study Results

Alzheimer’s disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal toxicity. They are prone to aggregation, yielding oligomers and fibrils through the inter-molecular binding between the amino acid sequences (17–42) of multiple amyloid-beta molecules. Additionally, amyloid deposition causes cerebral amyloid angiopathy. The present study aims to identify, in the existing literature, natural plant derived products possessing inhibitory properties against aggregation. The studies searched proved the anti-aggregating effects by the thioflavin T assay and through behavioral, biochemical, and histological analysis carried out upon administration of natural chemical compounds to transgenic mouse models of Alzheimer’s disease. According to our present study results, fifteen secondary metabolites from plants were identified which presented both evidence coming from the thioflavin T assay and transgenic mouse models developing Alzheimer’s disease and six additional metabolites were mentioned due to their inhibitory effects against fibrillogenesis. Among them, epigallocatechin-3-gallate, luteolin, myricetin, and silibinin were proven to lower the aggregation to less than 40%.

scholarly journals Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Cell Reports ◽  
2018 ◽  
Vol 22 (3) ◽  
pp. 832-847 ◽  
Author(s):  
Brad A. Friedman ◽  
Karpagam Srinivasan ◽  
Gai Ayalon ◽  
William J. Meilandt ◽  
Han Lin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Microglial Activation ◽  
Expression Profiles

P4-367: Sigmoidal kinetics of BETA-AMYLOID deposition: Twenty-year interval between normality and fully developed Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_21) ◽  
pp. S787-S787
Author(s):  
Victor Villemagne ◽  
Kathryn Ellis ◽  
Pierrick Bourgeat ◽  
Belinda Brown ◽  
Gareth Jones ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Amyloid Deposition ◽  
Sigmoidal Kinetics ◽  
Kinetics Of

[P2-197]: AMYLOID DEPOSITION, TAU AGGREGATION AND MICROGLIAL ACTIVATION CORRELATE WITH VASCULAR BURDEN IN VIVO IN ALZHEIMER'S DISEASE

2017 ◽  
Vol 13 (7S_Part_14) ◽  
pp. P681-P682 ◽  
Author(s):  
Melanie Dani ◽  
Zhen Fan ◽  
Melanie Wood ◽  
Ruth Mizoguchi ◽  
Richard Morgan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Microglial Activation ◽  
Amyloid Deposition ◽  
Tau Aggregation ◽  
Vascular Burden
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