scholarly journals Tumor Necrosis Factor-Induced Neutrophil Adhesion Occurs Via Sphingosine Kinase-1-Dependent Activation of Endothelial α5β1 Integrin

2010 ◽  
Vol 177 (1) ◽  
pp. 436-446 ◽  
Author(s):  
Wai Y. Sun ◽  
Stuart M. Pitson ◽  
Claudine S. Bonder
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Sphingosine Kinase ◽  
Neutrophil Adhesion ◽  
Sphingosine Kinase 1 ◽  
Α5β1 Integrin ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor Induces the Loss of Sphingosine Kinase-1 by a Cathepsin B-dependent Mechanism

2005 ◽  
Vol 280 (17) ◽  
pp. 17196-17202 ◽  
Author(s):  
Tarek A. Taha ◽  
Kazuyuki Kitatani ◽  
Jacek Bielawski ◽  
Wonhwa Cho ◽  
Yusuf A. Hannun ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Cathepsin B ◽  
Tumor Necrosis ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Necrosis Factor ◽  
Dependent Mechanism

scholarly journals Tumor necrosis factor-α exerts pro-myogenic action in C2C12 myoblasts via sphingosine kinase/S1P2signaling

FEBS Letters ◽  
2007 ◽  
Vol 581 (23) ◽  
pp. 4384-4388 ◽  
Author(s):  
Chiara Donati ◽  
Paola Nincheri ◽  
Francesca Cencetti ◽  
Elena Rapizzi ◽  
Marta Farnararo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Sphingosine Kinase ◽  
C2c12 Myoblasts ◽  
Factor Α ◽  
Necrosis Factor

ANTIBODY AGAINST NEUTROPHIL ADHESION COMPLEX CDW18 DOES NOT IMPROVE SURVIVAL OR PREVENT CARDIOPULMONARY ABNORMALITIES AFTER TUMOR NECROSIS FACTOR INFUSION IN DOGS

1990 ◽  
Vol 18 (Supplement) ◽  
pp. S259
Author(s):  
Peter Q. Eichacker ◽  
Dale Gruber ◽  
Tamyra Mouginis ◽  
William D. Hoffman ◽  
Steven M. Banks ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Neutrophil Adhesion ◽  
Adhesion Complex ◽  
Necrosis Factor

scholarly journals The Extracellular Adherence Protein from Staphylococcus aureus Inhibits Neutrophil Binding to Endothelial Cells

2004 ◽  
Vol 72 (10) ◽  
pp. 6164-6167 ◽  
Author(s):  
Axana Haggar ◽  
Cecilia Ehrnfelt ◽  
Jan Holgersson ◽  
Jan-Ingmar Flock
Keyword(s):  
Staphylococcus Aureus ◽  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Neutrophil Adhesion ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Adhesion Assays

ABSTRACT Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.

scholarly journals Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling.

2011 ◽  
Vol 286 (49) ◽  
pp. 42785.1-42785 ◽  
Author(s):  
Pu Xia ◽  
Lijun Wang ◽  
Paul A. B. Moretti ◽  
Nathaniel Albanese ◽  
Fugui Chai ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Sphingosine Kinase ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-α-stimulated Cell Proliferation Is Mediated through Sphingosine Kinase-dependent Akt Activation and Cyclin D Expression

2006 ◽  
Vol 282 (2) ◽  
pp. 863-870 ◽  
Author(s):  
Julie Radeff-Huang ◽  
Tammy M. Seasholtz ◽  
Jenny W. Chang ◽  
Jeffrey M. Smith ◽  
Colin T. Walsh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Sphingosine Kinase ◽  
Cyclin D ◽  
Akt Activation ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 ◽  
Vol 110 (2) ◽  
pp. 529-540 ◽  
Author(s):  
G A Zimmerman ◽  
T M McIntyre ◽  
M Mehra ◽  
S M Prescott
Keyword(s):  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Platelet Activating Factor ◽  
Neutrophil Adhesion ◽  
Necrosis Factor Alpha ◽  
A Cell ◽  
Paf Receptor ◽  
Factor Alpha ◽  
Necrosis Factor

The binding of neutrophils (polymorphonuclear leukocytes [PMNs]) to endothelial cells (ECs) presents special requirements in the regulation of intercellular adhesion. ECs that are stimulated by certain agonists, including thrombin and cytokines (tumor necrosis factor alpha, interleukin-1), generate molecular signals that induce the adhesion of PMNs (endothelial cell-dependent neutrophil adhesion). Our experiments demonstrate that the mechanism of binding induced by thrombin is distinct from that induced by the cytokines based on the time courses, the requirement for protein synthesis, and differential binding of HL60 promyelocytic leukemia cells to ECs activated by the two classes of agonists. The rapid EC-dependent PMN adhesion (initiated in minutes) that occurs when the ECs are stimulated by thrombin is temporally coupled with the accumulation of platelet-activating factor, a biologically active phosphoglyceride that remains associated with ECs and that activates PMNs by binding to a cell surface receptor. A portion of the newly synthesized platelet-activating factor (PAF) is on the EC surface, as demonstrated by experiments in which the rate of hydrolysis of PAF synthesized by activated ECs was accelerated by extracellular PAF acetylhydrolase. When ECs were treated with exogenous PAF they became adhesive for PMNs; the PMN binding was prevented by incubating the ECs with PAF acetylhydrolase or by treating the PMNs with competitive PAF receptor antagonists. Thus PAF associated with the EC plasma membrane induces PMN binding, an observation supported by experiments in which PAF in model membranes (liposomes) stimulated rapid PMN adhesion to ECs and to cell-free surfaces. In addition, competitive antagonists of the PAF receptor inhibited the binding of PMNs to ECs activated by thrombin and other rapidly acting agonists, but not to ECs activated by tumor necrosis factor alpha, indicating that PAF that is endogenously synthesized by ECs can mediate neutrophil adhesion. These experiments demonstrate a novel mechanism by which a cell-associated phospholipid, PAF, can serve as a signal for an intercellular adhesive event.

scholarly journals Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 ◽  
Vol 277 (10) ◽  
pp. 7996-8003 ◽  
Author(s):  
Pu Xia ◽  
Lijun Wang ◽  
Paul A. B. Moretti ◽  
Nathaniel Albanese ◽  
Fugui Chai ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Sphingosine Kinase ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Postanoxic T Lymphocyte–Endothelial Cell Interactions Induce Tumor Necrosis Factor-α Production and Neutrophil Adhesion

2000 ◽  
Vol 86 (12) ◽  
pp. 1237-1244 ◽  
Author(s):  
Satoshi Kokura ◽  
Robert E. Wolf ◽  
Toshikazu Yoshikawa ◽  
D. Neil Granger ◽  
Tak Yee Aw
Keyword(s):  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
T Lymphocyte ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cell Interactions ◽  
Neutrophil Adhesion ◽  
Factor Α ◽  
Necrosis Factor
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