scholarly journals Inhibition of Inducible Nitric Oxide Controls Pathogen Load and Brain Damage by Enhancing Phagocytosis of Escherichia coli K1 in Neonatal Meningitis

2010 ◽  
Vol 176 (3) ◽  
pp. 1292-1305 ◽  
Author(s):  
Rahul Mittal ◽  
Ignacio Gonzalez-Gomez ◽  
Kerstin A. Goth ◽  
Nemani V. Prasadarao
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Brain Damage ◽  
Neonatal Meningitis ◽  
Pathogen Load ◽  
Escherichia Coli K1 ◽  
Inducible Nitric Oxide

Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney

2001 ◽  
Vol 59 (3) ◽  
pp. 893-904 ◽  
Author(s):  
Mirjana Poljakovic ◽  
Maj-Lis Svensson ◽  
Catharina Svanborg ◽  
Kjell Johansson ◽  
Bengt Larsson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Use of Diagnostic Microarrays for Determination of Virulence Gene Patterns of Escherichia coli K1, a Major Cause of Neonatal Meningitis

2005 ◽  
Vol 43 (3) ◽  
pp. 1024-1031 ◽  
Author(s):  
B. Korczak ◽  
J. Frey ◽  
J. Schrenzel ◽  
G. Pluschke ◽  
R. Pfister ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Virulence Gene ◽  
Neonatal Meningitis ◽  
Escherichia Coli K1

scholarly journals Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney

2001 ◽  
Vol 59 (3) ◽  
pp. 893-904 ◽  
Author(s):  
Mirjana Poljakovic ◽  
Maj-Lis Svensson ◽  
Catharina Svanborg ◽  
Kjell Johansson ◽  
Bengt Larsson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Virulence patterns of Escherichia coli K1 strains associated with neonatal meningitis.

1997 ◽  
Vol 35 (11) ◽  
pp. 2981-2982 ◽  
Author(s):  
E Bingen ◽  
S Bonacorsi ◽  
N Brahimi ◽  
E Denamur ◽  
J Elion
Keyword(s):  
Escherichia Coli ◽  
Neonatal Meningitis ◽  
Escherichia Coli K1

scholarly journals O -Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli -Containing Vacuoles in Macrophage-Like Cells

2021 ◽  
Author(s):  
Jinghua Yang ◽  
Wei Ma ◽  
Yuanyuan Wu ◽  
Hui Zhou ◽  
Siyu Song ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Innate Immunity ◽  
Antibiotic Therapy ◽  
Polysialic Acid ◽  
Neonatal Meningitis ◽  
Lysosomal Degradation ◽  
Content Type ◽  
Mortality And Morbidity ◽  
E Coli ◽  
Escherichia Coli K1

Escherichia coli K1 is a leading cause of neonatal meningitis. The mortality and morbidity of this disease remain significantly high despite antibiotic therapy.

scholarly journals IL-10 administration reduces PGE-2 levels and promotes CR3-mediated clearance of Escherichia coli K1 by phagocytes in meningitis

2010 ◽  
Vol 207 (6) ◽  
pp. 1307-1319 ◽  
Author(s):  
Rahul Mittal ◽  
Ignacio Gonzalez-Gomez ◽  
Ashok Panigrahy ◽  
Kerstin Goth ◽  
Richard Bonnet ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Ex Vivo ◽  
Morphological Changes ◽  
Neonatal Meningitis ◽  
Prostaglandin E ◽  
Antibody Treatment ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Escherichia Coli K1

Ineffectiveness of antibiotics in treating neonatal Escherichia coli K1 meningitis and the emergence of antibiotic-resistant strains evidently warrants new prevention strategies. We observed that administration of interleukin (IL)-10 during high-grade bacteremia clears antibiotic-sensitive and -resistant E. coli from blood of infected mice. Micro-CT studies of brains from infected animals displayed gross morphological changes similar to those observed in infected human neonates. In mice, IL-10, but not antibiotic or anti-TNF antibody treatment prevented brain damage caused by E. coli. IL-10 administration elevated CR3 expression in neutrophils and macrophages of infected mice, whereas infected and untreated mice displayed increased expression of FcγRI and TLR2. Neutrophils or macrophages pretreated with IL-10 ex vivo exhibited a significantly greater microbicidal activity against E. coli compared with cells isolated from wild-type or IL-10−/− mice. The protective effect of IL-10 was abrogated when CR3 was knocked-down in vivo by siRNA. The increased expression of CR3 in phagocytes was caused by inhibition of prostaglandin E-2 (PGE-2) levels, which were significantly increased in neutrophils and macrophages upon E. coli infection. These findings describe a novel modality of IL-10–mediated E. coli clearance by diverting the entry of bacteria via CR3 and preventing PGE-2 formation in neonatal meningitis.

Sign in / Sign up

Export Citation Format

Share Document