scholarly journals Remodeling of the Fetal Collecting Duct Epithelium

2010 ◽  
Vol 176 (2) ◽  
pp. 630-637 ◽  
Author(s):  
Michael J. Hiatt ◽  
Larissa Ivanova ◽  
Nuria Toran ◽  
Alice F. Tarantal ◽  
Douglas G. Matsell
Keyword(s):  
Collecting Duct ◽  
Duct Epithelium ◽  
Collecting Duct Epithelium

scholarly journals Ontogeny of Purinergic Receptor-Regulated Ca2+ Signaling in Mouse Cortical Collecting Duct Epithelium

2002 ◽  
Vol 12 (2-3) ◽  
pp. 75-82 ◽  
Author(s):  
Johannes Tschöp ◽  
Gerald Braun ◽  
Rene Borscheid ◽  
Michael Horster ◽  
Stephan Huber
Keyword(s):  
Purinergic Receptor ◽  
Collecting Duct ◽  
Cortical Collecting Duct ◽  
Duct Epithelium ◽  
Collecting Duct Epithelium

scholarly journals Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Peter Trnka ◽  
Michael J. Hiatt ◽  
Larissa Ivanova ◽  
Alice F. Tarantal ◽  
Douglas G. Matsell
Keyword(s):  
De Novo ◽  
Epithelial Mesenchymal Transition ◽  
Interstitial Fibrosis ◽  
Urinary Tract Obstruction ◽  
Collecting Duct ◽  
Obstructive Nephropathy ◽  
Primate Model ◽  
Mesenchymal Transition ◽  
Duct Epithelium ◽  
Collecting Duct Epithelium

Epithelial-mesenchymal transition (EMT) has emerged in recent years as an important process in the development of organ fibrosis in many human diseases. Our previous experience in a nonhuman primate model of obstructive nephropathy suggested that EMT of collecting duct epithelium contributes to the development of interstitial fibrosis. In this study we demonstrate for the first time in humans that obstructed fetal collecting duct epithelium undergoes transition to mesenchymal phenotype, characterized by decreased expression of epithelial markers, de novo expression of mesenchymal markers with subsequent loss of cell-cell interaction, disruption of the basement membrane, and increased deposition of extracellular matrix into the expanded interstitium of the obstructed kidney. The results of this study therefore support the previous findings from animal studies and suggest that EMT of the collecting duct epithelium might contribute to the development of interstitial fibrosis in human fetal obstructive nephropathy.

scholarly journals Histochemical markers reveal an unexpected heterogeneous composition of the renal embryonic collecting duct epithelium

1993 ◽  
Vol 44 (3) ◽  
pp. 527-536 ◽  
Author(s):  
Sabine Kloth ◽  
Joachim Aigner ◽  
Ernst Brandt ◽  
Roland Moll ◽  
Will W. Minuth
Keyword(s):  
Collecting Duct ◽  
Duct Epithelium ◽  
Collecting Duct Epithelium

Acute effects of brief ureteral stasis on urinary and renal papillary chloride concentration

1960 ◽  
Vol 199 (6) ◽  
pp. 1215-1218 ◽  
Author(s):  
Richard H. Kessler
Keyword(s):  
Water Movement ◽  
Collecting Duct ◽  
Chloride Concentration ◽  
Chloride Content ◽  
Contralateral Side ◽  
Acute Effects ◽  
Duct Epithelium ◽  
Collecting Duct Epithelium ◽  
Filtered Load

According to the countercurrent hypothesis urine tonicity depends largely on osmotic equilibrium of collecting duct fluid with the hypertonic interstitium of the papilla. One suggested role of ADH is that of regulating water permeability of collecting duct epithelium. In water deprivation ADH would facilitate water movement from collecting duct to the hypertonic papilla. Support for this hypothesis is offered here. These studies use the observation that ureteral clamping curtails glomerular filtration. Hence, the filtered load of NaCl from which papillary stores are derived is reduced. Accordingly, the chloride content of papillary tissues obtained from dog kidneys subsequent to several minutes of ureteral clamping was compared to those from the opposite kidney. In saline-loaded animals stasis uniformly lowered tissue chloride with the production of urine lower in chloride content and hypotonic to that of the contralateral side. These alterations were minimized following urinary stasis in animals loaded with water, mannitol or saline plus ADH.

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium

2010 ◽  
Vol 200 (4) ◽  
pp. 347-359 ◽  
Author(s):  
M. Steensgaard ◽  
P. Svenningsen ◽  
A. R. Tinning ◽  
T. D. Nielsen ◽  
F. Jørgensen ◽  
...  
Keyword(s):  
Serine Protease ◽  
High Resistance ◽  
Protease Activity ◽  
Collecting Duct ◽  
Duct Epithelium ◽  
Serine Protease Activity ◽  
Renal Collecting Duct ◽  
Collecting Duct Epithelium

scholarly journals Aldosterone modulates PNA binding cell isoforms within renal collecting duct epithelium

1993 ◽  
Vol 44 (3) ◽  
pp. 537-544 ◽  
Author(s):  
Will W. Minuth ◽  
Wolfgang Fietzek ◽  
Sabine Kloth ◽  
Joachim Aigner ◽  
Peter Herter ◽  
...  
Keyword(s):  
Collecting Duct ◽  
Duct Epithelium ◽  
Renal Collecting Duct ◽  
Collecting Duct Epithelium ◽  
Binding Cell
Sign in / Sign up

Export Citation Format

Share Document