scholarly journals Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity

2009 ◽  
Vol 174 (5) ◽  
pp. 1575-1587 ◽  
Author(s):  
Sébastien André ◽  
David F. Tough ◽  
Sébastien Lacroix-Desmazes ◽  
Srini V. Kaveri ◽  
Jagadeesh Bayry
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Antigen Presenting Cells ◽  
Antigen Presenting

scholarly journals Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells

2020 ◽  
Vol 6 (40) ◽  
pp. eaba6584
Author(s):  
Tianzhen He ◽  
De Yang ◽  
Xiao-Qing Li ◽  
Mengmeng Jiang ◽  
Md Sahidul Islam ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Antigen Presenting Cells ◽  
Surface Expression ◽  
Pore Channel ◽  
Dependent Manner ◽  
Antigen Presenting

CD4+Foxp3+ regulatory T cells (Tregs) are pivotal for the inhibition of autoimmune inflammatory responses. One way to therapeutically harness the immunosuppressive actions of Tregs is to stimulate the proliferative expansion of TNFR2-expressing CD4+Foxp3+ Tregs via transmembrane TNF (tmTNF). Here, we report that two-pore channel (TPC) inhibitors markedly enhance tmTNF expression on antigen-presenting cells. Furthermore, injection of TPC inhibitors including tetrandrine, or TPC-specific siRNAs in mice, increases the number of Tregs in a tmTNF/TNFR2-dependent manner. In a mouse colitis model, inhibition of TPCs by tetrandrine markedly attenuates colon inflammation by expansion of Tregs. Mechanistically, we show that TPC inhibitors enhance tmTNF levels by disrupting surface expression of TNF-α–converting enzyme by regulating vesicle trafficking. These results suggest that the therapeutic potential of TPC inhibitors is mediated by expansion of TNFR2-expressing Tregs and elucidate the basis of clinical use in the treatment of autoimmune and other inflammatory diseases.

scholarly journals Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells

Hepatology ◽  
2005 ◽  
Vol 42 (1) ◽  
pp. 193-199 ◽  
Author(s):  
Christiane Wiegard ◽  
Christian Frenzel ◽  
Johannes Herkel ◽  
Karl-Josef Kallen ◽  
Edgar Schmitt ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Antigen Presenting Cells ◽  
Suppressor Activity ◽  
Murine Liver ◽  
Antigen Presenting
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