scholarly journals Interferon-γ Prevents Death of Bystander Neurons during CD8 T Cell Responses in the Brain

2009 ◽  
Vol 174 (5) ◽  
pp. 1799-1807 ◽  
Author(s):  
Kirsten Richter ◽  
Jürgen Hausmann ◽  
Peter Staeheli
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Interferon Γ ◽  
Cell Responses ◽  
The Brain

154 Interferon-gamma prevents death of bystander neurons during CD8 T-cell responses in the brain

Cytokine ◽  
2008 ◽  
Vol 43 (3) ◽  
pp. 272
Author(s):  
Kirsten Richter ◽  
Jürgen Hausmann ◽  
Peter Staeheli
Keyword(s):  
T Cell ◽  
Interferon Gamma ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
The Brain

Ex Vivo Analysis of Human Antigen-Specific CD8+ T-Cell Responses: Quality Assessment of Fluorescent HLA-A2 Multimer and Interferon-γ ELISPOT Assays for Patient Immune Monitoring

2004 ◽  
Vol 27 (4) ◽  
pp. 298-308 ◽  
Author(s):  
Daniel E. Speiser ◽  
Mikaël J. Pittet ◽  
Philippe Guillaume ◽  
Norbert Lubenow ◽  
Eric Hoffman ◽  
...  
Keyword(s):  
T Cell ◽  
Quality Assessment ◽  
Ex Vivo ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Interferon Γ ◽  
Immune Monitoring ◽  
Cell Responses

scholarly journals Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

2005 ◽  
Vol 201 (7) ◽  
pp. 1053-1059 ◽  
Author(s):  
Jason K. Whitmire ◽  
Joyce T. Tan ◽  
J. Lindsay Whitton
Keyword(s):  
T Cells ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Interferon Γ ◽  
Current Evidence ◽  
Cell Responses ◽  
Acute Viral Infection

Interferon-γ (IFNγ) is important in regulating the adaptive immune response, and most current evidence suggests that it exerts a negative (proapoptotic) effect on CD8+ T cell responses. We have developed a novel technique of dual adoptive transfer, which allowed us to precisely compare, in normal mice, the in vivo antiviral responses of two T cell populations that differ only in their expression of the IFNγ receptor. We use this technique to show that, contrary to expectations, IFNγ strongly stimulates the development of CD8+ T cell responses during an acute viral infection. The stimulatory effect is abrogated in T cells lacking the IFNγ receptor, indicating that the cytokine acts directly upon CD8+ T cells to increase their abundance during acute viral infection.

scholarly journals Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 236-242 ◽  
Author(s):  
Katayoun Rezvani ◽  
Agnes S. M. Yong ◽  
Stephan Mielke ◽  
Bipin N. Savani ◽  
Laura Musse ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Residual Disease ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Interferon Γ ◽  
Antigenic Peptides ◽  
Myeloid Malignancies ◽  
Cell Responses

We describe the safety and immunogenicity of a combined vaccine of 2 leukemia-associated antigenic peptides, PR1 and WT1. Eight patients with myeloid malignancies received one subcutaneous dose each of PR1 and WT1 vaccines in Montanide adjuvant, with granulocyte-macrophage colony-stimulating factor. Patients were reviewed weekly for 4 weeks to monitor toxicity and immunologic responses. Toxicity was limited to grades 1 to 2. Using peptide/HLA-A*0201 tetramers and intracellular interferon-γ staining, CD8+ T cells against PR1 or WT1 were detected in 8 of 8 patients after a single vaccination. To monitor the kinetics of vaccine-induced CD8+ T-cell responses and disease regression after vaccination, absolute PR1 and WT1+CD8+ T-cell numbers and WT1 expression were studied weekly after vaccination. Responses occurred as early as 1 week after vaccination. After vaccination, the emergence of PR1 or WT1+CD8+ T cells was associated with a decrease in WT1 mRNA expression as a marker of minimal residual disease, suggesting a vaccine-driven antileukemia effect. Conversely, loss of response was associated with reappearance of WT1 transcripts (P < .01). This is the first demonstration that a combined PR1 and WT1 vaccine is immunogenic. These results support further studies of combination immunization strategies in leukemia patients. This study is registered at http://clinicaltrials.gov as NCT00313638.

Development of an orthotopic HCC mouse model for analysis of tumor-specific CD8 T cell responses

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
D Ostroumov ◽  
MP Manns ◽  
S Kubicka ◽  
F Kühnel ◽  
T Wirth
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

Analysis of Successful Virus-Specific CD8+ T Cell Responses in acute HBV infection

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
E Panther ◽  
B Bengsch ◽  
T Böttler ◽  
N Nazarova ◽  
HC Spangenberg ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Hbv Infection ◽  
Cell Responses
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