scholarly journals Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases

2009 ◽  
Vol 174 (5) ◽  
pp. 1921-1930 ◽  
Author(s):  
Hannes Neuwirt ◽  
Martin Puhr ◽  
Frédéric R. Santer ◽  
Martin Susani ◽  
Wolfgang Doppler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Cytokine Signaling ◽  
Human Prostate Cancer ◽  
Suppressor Of Cytokine Signaling ◽  
Down Regulation ◽  
Cyclin Dependent Kinases ◽  
Inhibitory Function ◽  
Growth Inhibitory

scholarly journals Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer

2006 ◽  
Vol 169 (6) ◽  
pp. 2199-2208 ◽  
Author(s):  
Ilaria Bellezza ◽  
Hannes Neuwirt ◽  
Constanze Nemes ◽  
Ilaria T. Cavarretta ◽  
Martin Puhr ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Cytokine Signaling ◽  
Human Prostate Cancer ◽  
Suppressor Of Cytokine Signaling ◽  
Proliferation And Apoptosis

Increased expression of δ-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer

2005 ◽  
Vol 36 (10) ◽  
pp. 1037-1048 ◽  
Author(s):  
Qun Lu ◽  
Larry J. Dobbs ◽  
Christopher W. Gregory ◽  
George W. Lanford ◽  
Monica P. Revelo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Down Regulation ◽  
E Cadherin

scholarly journals Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 488 ◽  
Author(s):  
Yeong-Seon Won ◽  
Kwon-Il Seo
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Mtor Signaling ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Down Regulation ◽  
Cycle Arrest

Prostate cancer is the most common cancer in Western countries. Recently, Asian countries are being affected by Western habits, which have had an important role in the rapid increase in cancer incidence. Sanggenol L (San L) is a natural flavonoid present in the root barks of Morus alba, which induces anti-cancer activities in ovarian cancer cells. However, the molecular and cellular mechanisms of the effects of sanggenol L on human prostate cancer cells have not been elucidated. In this study, we investigated whether sanggenol L exerts anti-cancer activity in human prostate cancer cells via apoptosis and cell cycle arrest. Sanggenol L induced caspase-dependent apoptosis (up-regulation of PARP and Bax or down-regulation of procaspase-3, -8, -9, Bid, and Bcl-2), induction of caspase-independent apoptosis (up-regulation of AIF and Endo G on cytosol), suppression of cell cycle (down-regulation of CDK1/2, CDK4, CDK6, cyclin D1, cyclin E, cyclin A, and cyclin B1 or up-regulation of p53 and p21), and inhibition of PI3K/Akt/mTOR signaling (down-regulation of PI3K, p-Akt, and p-mTOR) in prostate cancer cells. These results suggest the induction of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in response to sanggenol L in prostate cancer cells.

Down-regulation of Hsp27 radiosensitizes human prostate cancer cells

2006 ◽  
Vol 13 (9) ◽  
pp. 1221-1225 ◽  
Author(s):  
SHAHRAM TEIMOURIAN ◽  
RAZIEH JALAL ◽  
MOSTAFA SOHRABPOUR ◽  
BAHRAM GOLIAEI
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Down Regulation

Growth inhibitory activity of lemnabourside on human prostate cancer cells

Life Sciences ◽  
2002 ◽  
Vol 70 (7) ◽  
pp. 843-853 ◽  
Author(s):  
W.K. Liu ◽  
N.L.Y. Wong ◽  
H.M. Huang ◽  
J.K.C. Ho ◽  
W.H. Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity
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