scholarly journals Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion

2008 ◽  
Vol 173 (3) ◽  
pp. 653-664 ◽  
Author(s):  
Akitoshi Nakashima ◽  
Arihiro Shiozaki ◽  
Subaru Myojo ◽  
Mika Ito ◽  
Mikiko Tatematsu ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Spontaneous Abortion ◽  
Killer Cells ◽  
Uterine Natural Killer Cells ◽  
Extravillous Trophoblasts ◽  
Uterine Natural Killer

scholarly journals Cannabinoid Signalling in Immune–Reproductive Crosstalk during Human Pregnancy

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 267
Author(s):  
Harmeet Gurm ◽  
Jeremy A. Hirota ◽  
Sandeep Raha
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Cannabinoid Receptors ◽  
Synthetic Cannabinoids ◽  
Endocannabinoid System ◽  
Therapeutic Benefit ◽  
Killer Cells ◽  
Uterine Natural Killer Cells ◽  
Extravillous Trophoblasts ◽  
Uterine Natural Killer

Despite the intricate involvement of the endocannabinoid system in various physiological processes, it remains one of the most under-studied biological systems of the human body. The scope of endocannabinoid signalling is widespread, ranging from modulation of immune responses in innate and adaptive immunity to gestational processes in female physiology. Cannabinoid receptors are ubiquitously distributed in reproductive tissues and are thought to play a role in regulating the immune–reproductive interactions required for successful pregnancy, specifically among uterine natural killer cells and placental extravillous trophoblasts. The use of cannabis during pregnancy, however, can perturb endocannabinoid homeostasis through effects mediated by its major constituents, Δ-9-tetrahydrocannabinol and cannabidiol. Decidualization of the endometrium, invasion, and angiogenesis may be impaired as a consequence, leading to clinical complications such as miscarriage and preeclampsia. In this review, the crosstalk between endocannabinoid signalling in uterine natural killer cells and placental extravillous trophoblasts will be examined in healthy and complicated pregnancies. This lays a foundation for discussing the potential of targeting the endocannabinoid system for therapeutic benefit, particularly with regard to the emerging field of synthetic cannabinoids.

scholarly journals Uterine Natural Killer Cells Severely Decrease in Number at Gestation Day 6 in Mice1

2013 ◽  
Vol 89 (4) ◽  
Author(s):  
Akiko Takashima ◽  
Fumio Ishikawa ◽  
Taku Kuwabara ◽  
Yuriko Tanaka ◽  
Toshihiko Kinoshita ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
Uterine Natural Killer Cells ◽  
Uterine Natural Killer
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