scholarly journals Macrophage Migration Inhibitory Factor Is Up-Regulated in Human First-Trimester Placenta Stimulated by Soluble Antigen of Toxoplasma gondii, Resulting in Increased Monocyte Adhesion on Villous Explants

2008 ◽  
Vol 172 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Eloisa Amália Vieira Ferro ◽  
José Roberto Mineo ◽  
Francesca Ietta ◽  
Nicoletta Bechi ◽  
Roberta Romagnoli ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
First Trimester ◽  
Inhibitory Factor ◽  
Soluble Antigen ◽  
Macrophage Migration ◽  
Monocyte Adhesion

scholarly journals Effect of Macrophage Migration Inhibitory Factor (MIF) in Human Placental Explants Infected with Toxoplasma gondii Depends on Gestational Age

2011 ◽  
Vol 178 (6) ◽  
pp. 2792-2801 ◽  
Author(s):  
Angelica de Oliveira Gomes ◽  
Deise Aparecida de Oliveira Silva ◽  
Neide Maria Silva ◽  
Bellisa de Freitas Barbosa ◽  
Priscila Silva Franco ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Gestational Age ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration

17β-Estradiol modulates the macrophage migration inhibitory factor secretory pathway by regulating ABCA1 expression in human first-trimester placenta

2010 ◽  
Vol 298 (3) ◽  
pp. E411-E418 ◽  
Author(s):  
Francesca Ietta ◽  
Nicoletta Bechi ◽  
Roberta Romagnoli ◽  
Jayonta Bhattacharjee ◽  
Massimo Realacci ◽  
...  
Keyword(s):  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Secretory Pathway ◽  
First Trimester ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Dependent Manner ◽  
Mutual Cooperation ◽  
17Β Estradiol

Successful pregnancy involves a series of events, most of them mediated by hormones and cytokines. Estrogens, besides being important for placental growth and embryo development, have a marked effect on the immune system exerting either pro- or anti-inflammatory properties. Numerous studies suggest that estrogens directly affect cellular function, including cytokine production. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in pregnancy, particularly during the earlier stages of placentation. Since reports on mice have shown that estrogens modulate MIF, herein we investigated the effect of estrogens on human placental MIF. By using an in vitro model of first-trimester chorionic villous explants, we found that 17β-estradiol (E2) was able to modulate the release of MIF in a dose-dependent manner (10−12 vs. 10−9 M, P < 0.05; 10−9 vs. 10−5 M, P < 0.05; 10−12 vs. 10−5 M, P < 0.001). Unlike MIF release, no significant change in tissue MIF protein or MIF mRNA was observed. We showed evidence that E2 concentrations (10−9 and 10−5 M) act on placental tissue downregulating the mRNA and protein expression of the ATP-binding cassette transporter protein A1, a membrane transporter involved in MIF secretion. These findings emphasize the mutual cooperation between hormones and cytokines and suggest that increasing estrogen levels with advancing gestation may have a major role in regulating placental MIF secretion.

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