scholarly journals Heme Oxygenase-1 Attenuates Ovalbumin-Induced Airway Inflammation by Up-Regulation of Foxp3 T-Regulatory Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β1

2007 ◽  
Vol 171 (6) ◽  
pp. 1904-1914 ◽  
Author(s):  
Zhen-Wei Xia ◽  
Li-Qing Xu ◽  
Wen-Wei Zhong ◽  
Jing-Jing Wei ◽  
Ning-Li Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Airway Inflammation ◽  
Heme Oxygenase ◽  
T Regulatory Cells ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Heme Oxygenase 1 ◽  
Regulatory Cells ◽  
Membrane Bound

Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-β1 in renal epithelial cells

2007 ◽  
Vol 293 (3) ◽  
pp. F885-F894 ◽  
Author(s):  
Amie Traylor ◽  
Thomas Hock ◽  
Nathalie Hill-Kapturczak
Keyword(s):  
Growth Factor ◽  
Heme Oxygenase ◽  
Transforming Growth Factor ◽  
Tissue Injury ◽  
Transforming Growth Factor Β1 ◽  
Molecular Regulation ◽  
Heme Oxygenase 1 ◽  
Specificity Protein 1 ◽  
Specificity Protein ◽  
Tgf Β1

Excess transforming growth factor-β1 (TGF-β1) in the kidney leads to increased cell proliferation and deposition of extracellular matrix, resulting in progressive kidney fibrosis. TGF-β1, however, stabilizes and attenuates tissue injury through the activation of cytoprotective proteins, including heme oxygenase-1 (HO-1). HO-1 catabolizes pro-oxidant heme into substances with anti-oxidant, anti-apoptotic, anti-fibrogenic, vasodilatory and immune modulatory properties. Little is known regarding the molecular regulation of human HO-1 induction by TGF-β1 except that it is dependent on de novo RNA synthesis and requires a group of structurally related proteins called Smads. It is not known whether other DNA binding proteins are required to initiate transcription of HO-1 and, furthermore, the promoter region(s) involved in TGF-β1-mediated induction of HO-1 has not been identified. The purpose of this study was to further delineate the molecular regulation of HO-1 by TGF-β1 in human renal proximal tubular cells. Actinomycin D and nuclear run-on studies demonstrate that TGF-β1 augments HO-1 expression by increased gene transcription and does not involve increased mRNA stability. Using transient transfection, mithramycin A, small interfering RNA, electrophoretic mobility shift assays, and decoy oligonucleotide experiments, a TGF-β1-responsive region is identified between 9.1 and 9.4 kb of the human HO-1 promoter. This ∼280-bp TGF-β1-responsive region contains a putative Smad binding element and specificity protein 1 binding sites, both of which are required for human HO-1 induction by TGF-β1.

scholarly journals Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0176052 ◽  
Author(s):  
Shu-Jui Kuo ◽  
Wei-Hung Yang ◽  
Shan-Chi Liu ◽  
Chun-Hao Tsai ◽  
Horng-Chaung Hsu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heme Oxygenase ◽  
Transforming Growth Factor ◽  
Synovial Fibroblasts ◽  
Transforming Growth Factor Β1 ◽  
Heme Oxygenase 1

scholarly journals Induction of Heme Oxygenase-1 During Endotoxemia Is Downregulated by Transforming Growth Factor-β1

1998 ◽  
Vol 83 (4) ◽  
pp. 396-403 ◽  
Author(s):  
Andrea Pellacani ◽  
Philippe Wiesel ◽  
Arunabh Sharma ◽  
Lauren C. Foster ◽  
Gordon S. Huggins ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heme Oxygenase ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Heme Oxygenase 1

scholarly journals Defining the role of transforming growth factor β1 in Foxp3+ T regulatory cells

Immunity ◽  
2021 ◽  
Vol 54 (3) ◽  
pp. 393-394
Author(s):  
Garam Choi ◽  
Byung-Seok Kim ◽  
Jae-Hoon Chang ◽  
Yeonseok Chung
Keyword(s):  
Growth Factor ◽  
T Regulatory Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Regulatory Cells

scholarly journals Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor β1 and T Regulatory Cells

2014 ◽  
Vol 189 (10) ◽  
pp. 1250-1259 ◽  
Author(s):  
Daniel R. Neill ◽  
William R. Coward ◽  
Jenna F. Gritzfeld ◽  
Luke Richards ◽  
Francesc J. Garcia-Garcia ◽  
...  
Keyword(s):  
Growth Factor ◽  
T Regulatory Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Regulatory Cells ◽  
Pneumococcal Carriage

scholarly journals Kruppel-like Factor KLF10 Targets Transforming Growth Factor-β1 to Regulate CD4+CD25−T Cells and T Regulatory Cells

2009 ◽  
Vol 284 (37) ◽  
pp. 24914-24924 ◽  
Author(s):  
Zhuoxiao Cao ◽  
Akm Khyrul Wara ◽  
Basak Icli ◽  
Xinghui Sun ◽  
René R. S. Packard ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
T Regulatory Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Regulatory Cells

Heme oxygenase‐1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells

2007 ◽  
Vol 21 (13) ◽  
pp. 3450-3457 ◽  
Author(s):  
Soo Sun Lee ◽  
Wenda Gao ◽  
Silvia Mazzola ◽  
Michael N. Thomas ◽  
Eva Csizmadia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
T Regulatory Cells ◽  
Heme Oxygenase 1 ◽  
Regulatory Cells ◽  
Islet Allografts
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