scholarly journals Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase

2007 ◽  
Vol 170 (6) ◽  
pp. 2100-2111 ◽  
Author(s):  
R. Daniel Bonfil ◽  
Zhong Dong ◽  
J. Carlos Trindade Filho ◽  
Aaron Sabbota ◽  
Pamela Osenkowski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Membrane Type

scholarly journals Oxidative Stress and Prostate Cancer Progression Are Elicited by Membrane-Type 1 Matrix Metalloproteinase

2011 ◽  
Vol 9 (10) ◽  
pp. 1305-1318 ◽  
Author(s):  
Hoang-Lan Nguyen ◽  
Stanley Zucker ◽  
Kevin Zarrabi ◽  
Pournima Kadam ◽  
Cathleen Schmidt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Membrane Type

Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines

2000 ◽  
Vol 155 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Osamu Nagakawa ◽  
Koji Murakami ◽  
Takeshi Yamaura ◽  
Yasuyoshi Fujiuchi ◽  
Jun Murata ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Membrane Type

scholarly journals Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer

2008 ◽  
Vol 283 (10) ◽  
pp. 6232-6240 ◽  
Author(s):  
Jian Cao ◽  
Christian Chiarelli ◽  
Omer Richman ◽  
Kevin Zarrabi ◽  
Pallavi Kozarekar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Membrane Type

434: Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Promotes Tumor Growth and Bone Degradation in Prostate Cancer Bone Metastasis

2006 ◽  
Vol 175 (4S) ◽  
pp. 141-141
Author(s):  
R. Daniel Bonfil ◽  
Zhong Dong ◽  
J. Carlos Trindade Filho ◽  
Huiren Zhao ◽  
Pamela Ossenkowski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Bone Degradation ◽  
Membrane Type

Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis

2005 ◽  
Vol 93 (04) ◽  
pp. 770-778 ◽  
Author(s):  
Christian Chiarelli ◽  
Pallavi Kozarekar ◽  
Howard Adler ◽  
Jian Cao
Keyword(s):  
Prostate Cancer ◽  
Basement Membrane ◽  
Matrix Metalloproteinase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lncap Cells ◽  
Membrane Type ◽  
Cancer Dissemination

SummaryDevelopment of metastases requires cancer cells to breach underlying basement membrane, migrate through interstitial stroma and gain access to blood or lymphatic vessels. Membrane type 1-matrix metalloproteinase (MT1-MMP) has been linked with these processes. Expression of MT1-MMP in human prostate cancer correlates with the stage of this disseminated disease. The mechanism underlying this observation, however, still remains to be understood. To study the role of MT1-MMP in prostate cancer dissemination, endogenous and recombinant MT1-MMP expressed in human prostate cancer cell lines (DU-145 and LNCaP) were examined. Using FITC-labeled Ma-trigel, a soluble basement membrane extract coated coverslips, LNCaP cells stably expressing a chimera of MT1-MMP and Green Fluorescent Protein (MT1-GFP) degraded Matrigel and readily migrated over degraded substrates. The degradation of Matrigel by LNCaP cells expressing MT1-GFP was sensitive to MMP inhibitors, CT-1746 and TIMP-2, but not TIMP-1. Cell migration was dramatically enhanced by expression of MT1-MMP. By employing surgical orthotopic implantation of LNCaP cells stably expressing MT1-GFP into the prostate gland of immunodeficient mice, we demonstrated that MT1-MMP promotes lymph node and lung metastasis of prostate cancer cells. Together, these results emphasize the pivotal role of MT1-MMP in prostate cancer dissemination and confirm that MT1-MMP is a suitable target to prevent cancer metastasis.

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