scholarly journals Role of the Integrin-Binding Protein Osteopontin in Lymphatic Metastasis of Breast Cancer

2006 ◽  
Vol 169 (1) ◽  
pp. 233-246 ◽  
Author(s):  
Alison L. Allan ◽  
Rosamma George ◽  
Sharon A. Vantyghem ◽  
Mark W. Lee ◽  
Nicole C. Hodgson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymphatic Metastasis ◽  
Binding Protein

Abstract 3084: The role of RNA-binding protein HuR in lung metastasis of triple-negative breast cancer

2011 ◽  
Author(s):  
Patsharaporn Techasintana ◽  
Matthew Michael Gubin ◽  
Joseph David Magee ◽  
Garrett MacKenzie Dahm ◽  
Ulus Atasoy
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

PTHrP P3 promoter activity in breast cancer cell lines: Role of Ets1 and CBP (CREB binding protein)

2007 ◽  
Vol 268 (1-2) ◽  
pp. 75-84 ◽  
Author(s):  
Hinda Hamzaoui ◽  
Marthe Rizk-Rabin ◽  
Jonthan Gordon ◽  
Carlos Offutt ◽  
Jérôme Bertherat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Promoter Activity ◽  
Binding Protein ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Creb Binding Protein

scholarly journals Association of Vitamin D Receptor and Vitamin D-Binding Protein Polymorphisms with Familial Breast Cancer Prognosis in a Mono-Institutional Cohort

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1208
Author(s):  
Valentina Aristarco ◽  
Harriet Johansson ◽  
Sara Gandini ◽  
Debora Macis ◽  
Cristina Zanzottera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Binding Protein ◽  
Cancer Prognosis ◽  
Consecutive Series ◽  
Nucleotide Polymorphisms ◽  
Vitamin D Binding Protein ◽  
Brca1 And Brca2

Low 25-hydroxyvitamin D (25OHD) has been associated with an increased cancer incidence and poorer prognosis. Single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and vitamin D binding protein (GC gene) may interfere with vitamin D activity. This study assesses the role of VDR and GC SNPs on breast cancer (BC) recurrence and survival in a cohort of patients with a family history of breast cancer, without the pathogenic variant for BRCA1 and BRCA2. A consecutive series of patients who underwent genetic testing were genotyped for VDR and GC genes. Specifically, ApaI, FokI, TaqI, BsmI and rs2282679, rs4588, rs7041 SNPs were determined. A total of 368 wild type (WT) patients with BC were analyzed for VDR and GC SNPs. The GC rs2282679 minor allele was significantly associated with luminal subtype of the primary tumor compared to Her2+/TN breast cancer (p = 0.007). Multivariate Cox models showed that BmsI and TaqI are significantly associated with BC outcome. Patients with the major alleles showed more than 30% lower hazard of relapse (BsmI p = 0.02 and TaqI p = 0.03). Our study supports the evidence for a pivotal role of 25OHD metabolism in BC. GC SNPs may influence the hormone tumor responsiveness and VDR may affect tumor prognosis.

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