scholarly journals Protective Effect of Proteinase-Activated Receptor 2 Activation on Motility Impairment and Tissue Damage Induced by Intestinal Ischemia/Reperfusion in Rodents

2006 ◽  
Vol 169 (1) ◽  
pp. 177-188 ◽  
Author(s):  
Fiore Cattaruzza ◽  
Nicolas Cenac ◽  
Elisabetta Barocelli ◽  
Mariannina Impicciatore ◽  
Eric Hyun ◽  
...  
Clinics ◽  
2013 ◽  
Vol 68 (7) ◽  
pp. 1034-1038 ◽  
Author(s):  
FJ Guzmán-de la Garza ◽  
JM Ibarra-Hernández ◽  
P Cordero-Pérez ◽  
P Villegas-Quintero ◽  
CI Villarreal-Ovalle ◽  
...  

Surgery Today ◽  
2010 ◽  
Vol 40 (9) ◽  
pp. 858-865 ◽  
Author(s):  
Xiao-Feng Tian ◽  
Ji-Hong Yao ◽  
Xue-Song Zhang ◽  
Shu-Sen Zheng ◽  
Xin-Hua Guo ◽  
...  

2017 ◽  
Vol 131 (11) ◽  
pp. 1137-1140 ◽  
Author(s):  
Laurent Dollé

This commentary highlights the research presented by Zhu et al. [1]. In this issue of the Clinical Science, the authors evaluated the protective effect of Alda-1 (a novel class of small molecule aldehyde dehydrogenase (ALDH2) activators) in the intestinal ischemia reperfusion (IR) injury. Remarkably, enhancing the ADLH2 activity by the use of Alda-1 can ameliorate several deleterious effects related to aldehydes, and may provide a better protection against an injury preestablished by IR. Together, an innovative metabolic strategy for treating patients with IR injury could be the use of ALDH modulators in a near future.


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