scholarly journals SUMOylation Attenuates Sensitivity toward Hypoxia- or Desferroxamine-Induced Injury by Modulating Adaptive Responses in Salivary Epithelial Cells

2006 ◽  
Vol 168 (5) ◽  
pp. 1452-1463 ◽  
Author(s):  
Ha-Van Nguyen ◽  
Jo-Lin Chen ◽  
Jenny Zhong ◽  
Kwang-Jin Kim ◽  
Edward D. Crandall ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Adaptive Responses ◽  
Salivary Epithelial Cells

scholarly journals P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells

2009 ◽  
Vol 13 (3) ◽  
pp. 175 ◽  
Author(s):  
Sung-Min Hwang ◽  
Na-Youn Koo ◽  
Se-Young Choi ◽  
Gae-Sig Chun ◽  
Joong-Soo Kim ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
P2x7 Receptor ◽  
Membrane Blebbing ◽  
Salivary Epithelial Cells

Evidence for the presence of a Hg-inhibitable water-permeability pathway and aquaporin 1 in A5 salivary epithelial cells

1995 ◽  
Vol 164 (3) ◽  
pp. 613-619 ◽  
Author(s):  
Krzysztof W. Lazowski ◽  
Jun Li ◽  
Christine Delporte ◽  
Bruce J. Baum
Keyword(s):  
Epithelial Cells ◽  
Water Permeability ◽  
Aquaporin 1 ◽  
Salivary Epithelial Cells

The Preparation of Silk Fibroin Modified PBT-co-PBS/PEG Composite Films and their Effects on Clinical Human Salivary Epithelial Cells Transplantation

2013 ◽  
Vol 18 ◽  
pp. 29-42
Author(s):  
Jie Zhu ◽  
Yue Ming Zhang ◽  
Zhi Cheng Tao ◽  
Nan Wei Xu ◽  
Li Qun Wang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Plasma Treatment ◽  
Silk Fibroin ◽  
High Surface ◽  
Composite Films ◽  
Contact Angles ◽  
Butylene Succinate ◽  
Poly Ethylene ◽  
Surface Modified ◽  
Salivary Epithelial Cells

We reported the preparation of surface modified poly(butylene terephthalate)-co-poly(butylene succinate)-b-poly(ethylene glycol) (i.e. PBT-co-PBS/PEG) films by three methods: silk fibroin coating, SO2 plasma treatment and silk fibroin anchoring. The obtained composite films were named SF/(PBT-co-PBS/PEG), SO2/(PBT-co-PBS/PEG) and SF/SO2/(PBT-co-PBS/PEG), respectively. Their surface properties were characterized by contact angles, surface energies and XPS. The biocompatibility of the films were further evaluated by the morphology, attachment, proliferation and viability of human salivary epithelial cells (HSG cells). Results revealed that SF/SO2/(PBT-co-PBS/PEG) possessed the high surface free energy (59.67 mJ/m2) and could immobilize a great amount of fibroin (SF surface coverage: 26.39 wt%), which attributed to the formation of such polar groups as hydrosulfide group, sulfonic group, carboxyl and carbonyl ones in the process of SO2 plasma treatment. The cell tests suggested that the silk fibroin anchoring could significantly enhance the biocompatibility of PBT-co-PBS/PEG, which implied the potential application of fibroin modified PBT-co-PBS/PEG for clinical HSG cells transplantation in artificial salivary gland constructs.

scholarly journals P2Y2nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells

2014 ◽  
Vol 307 (1) ◽  
pp. C83-C96 ◽  
Author(s):  
Farid G. El-Sayed ◽  
Jean M. Camden ◽  
Lucas T. Woods ◽  
Mahmoud G. Khalafalla ◽  
Michael J. Petris ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Rho Gtpase ◽  
Ex Vivo ◽  
Growth Factor Receptor ◽  
Cell Aggregation ◽  
Receptor Activation ◽  
Self Organization ◽  
Salivary Epithelial Cells

Hyposalivation resulting from salivary gland dysfunction leads to poor oral health and greatly reduces the quality of life of patients. Current treatments for hyposalivation are limited. However, regenerative medicine to replace dysfunctional salivary glands represents a revolutionary approach. The ability of dispersed salivary epithelial cells or salivary gland-derived progenitor cells to self-organize into acinar-like spheres or branching structures that mimic the native tissue holds promise for cell-based reconstitution of a functional salivary gland. However, the mechanisms involved in salivary epithelial cell aggregation and tissue reconstitution are not fully understood. This study investigated the role of the P2Y2nucleotide receptor (P2Y2R), a G protein-coupled receptor that is upregulated following salivary gland damage and disease, in salivary gland reconstitution. In vitro results with the rat parotid acinar Par-C10 cell line indicate that P2Y2R activation with the selective agonist UTP enhances the self-organization of dispersed salivary epithelial cells into acinar-like spheres. Other results indicate that the P2Y2R-mediated response is dependent on epidermal growth factor receptor activation via the metalloproteases ADAM10/ADAM17 or the α5β1integrin/Cdc42 signaling pathway, which leads to activation of the MAPKs JNK and ERK1/2. Ex vivo data using primary submandibular gland cells from wild-type and P2Y2R−/−mice confirmed that UTP-induced migratory responses required for acinar cell self-organization are mediated by the P2Y2R. Overall, this study suggests that the P2Y2R is a promising target for salivary gland reconstitution and identifies the involvement of two novel components of the P2Y2R signaling cascade in salivary epithelial cells, the α5β1integrin and the Rho GTPase Cdc42.

CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells

2021 ◽  
pp. 110042
Author(s):  
Mei Mei ◽  
Ling-Han Qu ◽  
Xin Cong ◽  
Yan Zhang ◽  
Ruo-Lan Xiang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Barrier Dysfunction ◽  
Tnf Α ◽  
Induced Apoptosis ◽  
Salivary Epithelial Cells

scholarly journals Inhibition of PKCα induces a PKCδ-dependent apoptotic program in salivary epithelial cells

2003 ◽  
Vol 10 (3) ◽  
pp. 269-277 ◽  
Author(s):  
A A Matassa ◽  
R L Kalkofen ◽  
L Carpenter ◽  
T J Biden ◽  
M E Reyland
Keyword(s):  
Epithelial Cells ◽  
Salivary Epithelial Cells

scholarly journals Identification of Regulatory Factors for Mesenchymal Stem Cell-Derived Salivary Epithelial Cells in a Co-Culture System

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112158 ◽  
Author(s):  
Yun-Jong Park ◽  
Jin Koh ◽  
Adrienne E. Gauna ◽  
Sixue Chen ◽  
Seunghee Cha
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Mesenchymal Stem Cell ◽  
Culture System ◽  
Regulatory Factors ◽  
Salivary Epithelial Cells

scholarly journals P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

2017 ◽  
Vol 292 (40) ◽  
pp. 16626-16637 ◽  
Author(s):  
Mahmoud G. Khalafalla ◽  
Lucas T. Woods ◽  
Jean M. Camden ◽  
Aslam A. Khan ◽  
Kirsten H. Limesand ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mouse Model ◽  
P2x7 Receptor ◽  
Receptor Antagonism ◽  
Autoimmune Exocrinopathy ◽  
Salivary Epithelial Cells
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