scholarly journals Activated Polyamine Catabolism in Acute Pancreatitis

2006 ◽  
Vol 168 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Mervi T. Hyvönen ◽  
Karl-Heinz Herzig ◽  
Riitta Sinervirta ◽  
Elke Albrecht ◽  
Isto Nordback ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Polyamine Catabolism

Polyamine Catabolism in Relation to Trypsin Activation and Apoptosis in Experimental Acute Pancreatitis

Pancreatology ◽  
2011 ◽  
Vol 11 (2) ◽  
pp. 83-91 ◽  
Author(s):  
Hai-Tao Jin ◽  
Teemu Lämsä ◽  
Panu H. Nordback ◽  
Mervi T. Hyvönen ◽  
Sari Räty ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Experimental Acute Pancreatitis ◽  
Polyamine Catabolism

Mechanisms of polyamine catabolism-induced acute pancreatitis

2007 ◽  
Vol 35 (2) ◽  
pp. 326-330 ◽  
Author(s):  
M.T. Hyvönen ◽  
M. Merentie ◽  
A. Uimari ◽  
T.A. Keinänen ◽  
J. Jänne ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Cathepsin B ◽  
Tissue Injury ◽  
Necrotizing Pancreatitis ◽  
Acinar Cells ◽  
Pancreatic Tissue ◽  
Early Event ◽  
Zymogen Activation ◽  
Polyamine Catabolism ◽  
Trypsinogen Activation

Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the tissues in the mammalian body, pancreas has the highest concentration of the natural polyamine, spermidine. We have found that pancreas is very sensitive to acute decreases in the concentrations of the higher polyamines, spermidine and spermine. Activation of polyamine catabolism in transgenic rats overexpressing SSAT (spermidine/spermine-N1-acetyltransferase) in the pancreas leads to rapid depletion of these polyamines and to acute necrotizing pancreatitis. Replacement of the natural polyamines with methylated polyamine analogues before the induction of acute pancreatitis prevents the development of the disease. As premature trypsinogen activation is a common, early event leading to tissue injury in acute pancreatitis in human and in experimental animal models, we studied its role in polyamine catabolism-induced pancreatitis. Cathepsin B, a lysosomal hydrolase mediating trypsinogen activation, was activated just 2 h after induction of SSAT. Pre-treatment of the rats with bismethylspermine prevented pancreatic cathepsin B activation. Analysis of tissue ultrastructure by transmission electron microscopy revealed early dilatation of rough endoplasmic reticulum, probable disturbance of zymogen packaging, appearance of autophagosomes and later disruption of intracellular membranes and organelles. Based on these results, we suggest that rapid eradication of polyamines from cellular structures leads to premature zymogen activation and autodigestion of acinar cells.

scholarly journals Activation of polyamine catabolism in transgenic rats induces acute pancreatitis

2000 ◽  
Vol 97 (15) ◽  
pp. 8290-8295 ◽  
Author(s):  
L. Alhonen ◽  
J. J. Parkkinen ◽  
T. Keinanen ◽  
R. Sinervirta ◽  
K.-H. Herzig ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Transgenic Rats ◽  
Polyamine Catabolism

Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis

Pancreatology ◽  
2010 ◽  
Vol 10 (2-3) ◽  
pp. 208-221 ◽  
Author(s):  
M.T. Hyvönen ◽  
R. Sinervirta ◽  
T.A. Keinänen ◽  
T. Fashe ◽  
N. Grigorenko ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Polyamine Catabolism ◽  
Polyamine Analogs

scholarly journals A Polyamine Analogue Prevents Acute Pancreatitis and Restores Early Liver Regeneration in Transgenic Rats with Activated Polyamine Catabolism

2002 ◽  
Vol 277 (42) ◽  
pp. 39867-39872 ◽  
Author(s):  
Tiina-Liisa Räsänen ◽  
Leena Alhonen ◽  
Riitta Sinervirta ◽  
Tuomo Keinänen ◽  
Karl-Heinz Herzig ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Liver Regeneration ◽  
Transgenic Rats ◽  
Polyamine Catabolism ◽  
Polyamine Analogue

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

Amino Acids ◽  
2007 ◽  
Vol 33 (2) ◽  
pp. 323-330 ◽  
Author(s):  
M. Merentie ◽  
A. Uimari ◽  
M. Pietilä ◽  
R. Sinervirta ◽  
T. A. Keinänen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Polyamine Catabolism

Levetiracetam Induced Acute Pancreatitis Case in Pregnancy

2013 ◽  
Vol 40 (06) ◽  
pp. 896 ◽  
Author(s):  
Murat Sarikaya ◽  
Nesibe Taser ◽  
Zeynal Dogan ◽  
Bilal Ergul ◽  
F. Irsel Tezer ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
In Pregnancy
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