scholarly journals Neck pain intensity does not predict pressure pain hyperalgesia: re-analysis of seven randomized controlled trials

2014 ◽  
Vol 46 (6) ◽  
pp. 553-560 ◽  
Author(s):  
R Lauche ◽  
H Cramer ◽  
J Langhorst ◽  
G Dobos ◽  
B Gerdle
Keyword(s):  
Neck Pain ◽  
Randomized Controlled Trials ◽  
Pain Intensity ◽  
Controlled Trials ◽  
Pressure Pain ◽  
Randomized Controlled

scholarly journals Traditional Chinese Mind and Body Exercises for Neck Pain: A Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yu-Hua Xie ◽  
Man-Xia Liao ◽  
Mao-Yuan Wang ◽  
W. C. Hewith A. Fernando ◽  
Yue-Ming Gu ◽  
...  
Keyword(s):  
Neck Pain ◽  
Randomized Controlled Trials ◽  
Pain Intensity ◽  
Short Form ◽  
Meta Analysis ◽  
Functional Mobility ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Sf 36 ◽  
Mind And Body

Background. Neck pain is common and can have a significant impact on patients’ physical functionality, mobility, and quality of life (QOL). In clinical practice, traditional Chinese mind and body exercise (TCMBE) is a combination of different types of exercise based on traditional Chinese medicine, including qigong, tai chi, the 12-words-for-life-nurturing exercise, and so on, and many studies have found that it is safe and effective at helping patients with neck pain. Objective. The aim of this study was to investigate the effectiveness of TCMBE on pain intensity, functional mobility, and QOL in individuals with neck pain. Methods. The PubMed, MEDLINE, PEDro, and Embase databases were systematically searched for relevant studies. Randomized controlled trials reporting the effects of TCMBE on pain intensity, functional mobility, and QOL in individuals with neck pain were included. Screening, data extraction, and literature quality assessments were performed independently by two reviewers. RevMan5.4 software was used for data analysis. Results. Six studies with 716 participants met the inclusion criteria. Compared with the control groups, TCMBE had no therapeutic advantage in improving pain intensity (visual analogue scale: mean difference (MD) = 1.8, 95% confidence interval (CI): −7.70 to 11.46, and P  = 0.70); functional mobility (neck disability index: MD = 0.15, 95% CI: −6.37 to 6.66, and P  = 0.96; neck pain and disability scale: MD = 1.31, 95% CI: −4.10 to 6.71, and P  = 0.64); or 36-item short-form health survey (SF-36) scores for physical function (MD = 5.58, 95% CI: −8.03 to 19.18, and P  = 0.42), general health (MD = 1.87, 95% CI: −4.99 to 8.72, and P  = 0.59), body pain (MD = 2.26, 95% CI: −3.80 to 8.32, and P  = 0.46), vitality (MD = 6.24, 95% CI: −1.49 to 13.98, and P  = 0.11), social function (MD = 8.06, 95% CI: −4.85 to 20.98, and P  = 0.22), role physical (MD = –1.46, 95% CI: −8.54 to 5.62, and P  = 0.69), or role emotional (MD = 6.5, 95% CI: −3.45 to 16.45, and P  = 0.2). However, TCMBE was less effective at improving mental health results based on the SF-36 survey (MD = 3.37, 95% CI: 0.5 to 6.24, and P  = 0.02). Conclusions. Based on the meta-analysis, there is insufficient evidence to support the clinical use of TCMBE in improving pain intensity and enhancing functional mobility and QOL in individuals with neck pain.

scholarly journals Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Lijun Shi ◽  
Haiyun Zhu ◽  
Jinhui Ma ◽  
Li-Li Shi ◽  
Fuqiang Gao ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Randomized Controlled Trials ◽  
Pain Intensity ◽  
Opioid Consumption ◽  
Knee Surgery ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Arthroscopic Knee Surgery ◽  
Randomized Controlled ◽  
Arthroscopic Knee

Abstract Objective We aimed to evaluate the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery. Methods We searched PubMed, Embase, Medline, Cochrane library, and Web of Science to identify randomized controlled trials that compared postoperative pain outcomes with or without IA Mg after knee arthroscopy. The primary outcomes were pain intensity at rest and with movement at different postoperative time points and cumulative opioid consumption within 24 h after surgery. Secondary outcomes included the time to first analgesic request and side effects. Results In total, 11 studies involving 677 participants met the eligibility criteria. Pain scores at rest and with movement 2, 4, 12, and 24 h after surgery were significantly lower, doses of supplementary opioid consumption were smaller, and the time to first analgesic requirement was longer in the IA Mg group compared with the control group. No significant difference was detected regarding adverse reactions between the groups. Conclusions Intra-articular magnesium is an effective and safe coadjuvant treatment for relieving postoperative pain intensity after arthroscopic knee surgery. Protocol registration at PROSPERO: CRD42020156403.

scholarly journals Improving Power and Accuracy in Randomized Controlled Trials of Pain Treatments by Accounting for Concurrent Analgesic Use: Statistical Simulations and Analyses of Randomized Controlled Trial Data

2021 ◽  
Author(s):  
Pradeep Suri ◽  
Patrick J Heagerty ◽  
Anna Korpak ◽  
Mark P Jensen ◽  
Laura S Gold ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Pain Intensity ◽  
Rating Scale ◽  
Controlled Trial ◽  
Simulated Data ◽  
Alternative Methods ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Analytic Methods ◽  
Analgesic Use

The 0 to 10 numeric rating scale (NRS) of pain intensity is a standard outcome in randomized controlled trials (RCTs) of pain treatments. For individuals taking analgesics, there may be a disparity between 'observed' pain intensity (the NRS, irrespective of concurrent analgesic use), and 'underlying' pain intensity (what the NRS would be had concurrent analgesics not been taken). Using a contemporary causal inference framework, we compare analytic methods that can potentially account for concurrent analgesic use, first in statistical simulations, and second in analyses of real (non-simulated) data from an RCT of lumbar epidural steroid injections (LESI). The default analytic method was ignoring analgesic use, which is the most common approach in pain RCTs. Compared to ignoring analgesic use and other analytic methods, simulations showed that a quantitative pain and analgesia composite outcome based on adding 1.5 points to observed pain intensity for those who were taking an analgesic (the QPAC1.5) optimized power and minimized bias. Analyses of real RCT data supported the results of the simulations, showing greater power with analysis of the QPAC1.5 as compared to ignoring analgesic use and most other methods examined. We propose alternative methods that should be considered in the analysis of pain RCTs.

Reliability of 3 Assessment Tools Used to Evaluate Randomized Controlled Trials for Treatment of Neck Pain

Spine ◽  
2012 ◽  
Vol 37 (6) ◽  
pp. 515-522 ◽  
Author(s):  
Nadine Graham ◽  
Ted Haines ◽  
Charlie H. Goldsmith ◽  
Anita Gross ◽  
Stephen Burnie ◽  
...  
Keyword(s):  
Neck Pain ◽  
Randomized Controlled Trials ◽  
Assessment Tools ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals The Beneficial Effects of Traditional Chinese Exercises for Adults with Low Back Pain: A Meta-Analysis of Randomized Controlled Trials

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 118 ◽  
Author(s):  
Yanjie Zhang ◽  
Paul D. Loprinzi ◽  
Lin Yang ◽  
Jing Liu ◽  
Shijie Liu ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Randomized Controlled Trials ◽  
Pain Intensity ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Low Back ◽  
Beneficial Effects ◽  
Randomized Controlled ◽  
Vas Scores

Objective: The aim of this meta-analytic review was to quantitatively examine the effects of traditional Chinese exercises (TCE) on pain intensity and back disability in individuals with low back pain (LBP). Methods: Potential articles were retrieved using seven electronic databases (Medline, Embase, Cinahl, Web of Science, Cochrane library, China National Knowledge Infrastructure, and Wanfang). The searched period was from inception to 1 March 2019. Randomized controlled trials (RCTs) assessing the effect of TCE on pain intensity and back disability in LBP patients were included. Pooled effect sizes were calculated using the random-effects models and 95% confidence interval (95% CI). Results: Data from eleven RCTs (886 individuals with LBP) meeting the inclusion criteria were extracted for meta-analysis. Compared with the control intervention, TCE induced significant improvements in the visual analogue scale (VAS) (Hedge’s g = −0.64, 95% CI −0.90 to −0.37, p < 0.001), Roland–Morris Disability Questionnaire (RMDQ) (Hedge’s g = −0.41, 95% CI −0.79 to −0.03, p = 0.03), Oswestry Disability Index (ODI) (Hedge’s g = −0.96, 95% CI −1.42 to −0.50, p < 0.001), and cognitive function (Hedge’s g = −0.62, 95% CI −0.85 to −0.39, p < 0.001). In a meta-regression analysis, age (β = 0.01, p = 0.02) and total exercise time (β = −0.0002, p = 0.01) were associated with changes in the VAS scores, respectively. Moderator analyses demonstrated that Tai Chi practice (Hedge’s g = −0.87, 95% CI −1.38 to −0.36, p < 0.001) and Qigong (Hedge’s g = −0.54, 95% CI −0.86 to −0.23, p < 0.001) reduced VAS scores. Interventions with a frequency of 1–2 times/week (Hedge’s g = −0.53, 95% CI −0.98 to −0.07, p = 0.02) and 3–4 times/week (Hedge’s g = −0.78, 95% CI −1.15 to −0.42, p < 0.001) were associated with reduced VAS scores, but this significant reduction on this outcome was not observed in the weekly training frequency of ≥5 times (Hedge’s g = −0.54, 95% CI −1.16 to 0.08, p = 0.09). Conclusions: TCE may have beneficial effects for reducing pain intensity for individuals with LBP, regardless of their pain status.

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