Effect of Maternal Metformin Treatment in Pregnancy on Neonatal Metabolism: Evidence From Newborn Metabolic Screening

10.2337/figshare.15148788.v1 ◽

2021 ◽

Author(s):

Jane Estrella ◽

Veronica Wiley ◽

David Simmons ◽

Tien-Ming Hng ◽

Mark McLean

Keyword(s):

Normal Population ◽

Vitamin B12 Deficiency ◽

Maternal Diabetes ◽

Exposed Group ◽

Mass Spectrometry Data ◽

Metformin Treatment ◽

Retrospective Case ◽

South Wales ◽

Normal Controls ◽

In Pregnancy

Objective: To investigate effects of maternal diabetes and metformin treatment on metabolic newborn screening (NBS) results of infants born to mothers with hyperglycemia during pregnancy Research Design and Methods: Retrospective case-control study. NBS results of infants born to mothers treated with metformin for hyperglycaemia during pregnancy were compared with diet-treated diabetes and matched normal controls. Exclusions: maternal type 1 diabetes, major fetal anomalies, incomplete infant data. Inclusions: maternal hyperglycemia in pregnancy treated with diet alone or diet plus metformin. Results from the New South Wales NBSP (dried infant bloodspot sample, 24-72 hours after birth) for 25 routinely studied analytes, were measured using mass spectrometry. Data from metformin-exposed and control infants were compared using non-parametric methods and multiples of the median for each analyte. Results: 574 cases were compared with 952 diet-treated diabetes cases and 979 controls. Metformin-exposed infants had shorter gestational age (266 days ±7 vs 272±10±34vs 274 ±9 ) (p= <0.001) and lower birth weights (3.28 kg ±0.51vs 3.29±0.49 ±0.52 vs 3.33±0.43) (p=0.008). Short, medium and one long-chain acylcarntine (tetradecanoylcarnitine; C14) concentrations were higher in the metformin exposed group compared to normal controls. Comparison with diet-treated diabetes controls (to eliminate confounding by hyperglycemia) continued to show raised butyrylcarntine (C4), isovalerylcarnitine (C5), glutarylcarnitine (C5D) in the metformin-exposed group. There was no evidence of vitamin B12 deficiency (low methionine, elevated propionylcarnitine; C3) in metformin-exposed infants. All results were within normal population limits. Conclusions: We have identified subtle (non-pathological) changes in neonatal metabolism which represents a signature effect of fetal metformin exposure.

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Varicella zoster and herpes simplex virus infections in pregnancy: Retrospective case series from central Europe

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2008.11.528 ◽

2009 ◽

Vol 60 (3) ◽

pp. AB119

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Central Europe ◽

Case Series ◽

Virus Infections ◽

Retrospective Case ◽

Varicella Zoster ◽

Retrospective Case Series ◽

Simplex Virus ◽

In Pregnancy

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Audit of insulin detemir in pregnancy: a retrospective case series

Diabetic Medicine ◽

10.1111/j.1464-5491.2012.03580.x ◽

2012 ◽

Vol 29 (7) ◽

pp. 958-959 ◽

Cited By ~ 7

Author(s):

V. V. Shenoy ◽

S. J. Cook ◽

A. F. Parry ◽

H. D. McIntyre

Keyword(s):

Insulin Detemir ◽

Case Series ◽

Retrospective Case ◽

Retrospective Case Series ◽

In Pregnancy

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Serum thiocyanate levels in a normal population and in pregnancy in Benin City, Nigeria: preliminary report

International Journal of Gynecology & Obstetrics ◽

10.1016/0020-7292(91)90541-c ◽

1991 ◽

Vol 34 (1) ◽

pp. 65-69 ◽

Cited By ~ 2

Author(s):

I.A.O. Oforofuo ◽

A.E. Omu

Keyword(s):

Preliminary Report ◽

Normal Population ◽

Benin City ◽

Serum Thiocyanate ◽

In Pregnancy

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Personal Social Capital and Socio-occupational Function of Persons with Schizophrenia: A Comparative Study

Indian Journal of Psychiatric Social Work ◽

10.29120/ijpsw.2019.v10.i1.63 ◽

2019 ◽

Vol 10 (1) ◽

pp. 34

Author(s):

Nilesh Maruti Gujar ◽

Lokesh Kumar Ranjan ◽

Deepanjan Bhattacharjee ◽

Basudeb Das ◽

Narendra Kumar Singh

Keyword(s):

Social Capital ◽

Normal Population ◽

General Health Questionnaire ◽

Occupational Functioning ◽

Syndrome Scale ◽

Significant Difference ◽

Persons With Schizophrenia ◽

Negative Syndrome ◽

Normal Controls ◽

Occupational Function

Background: Personal social capital is an individualÃ¢â‚¬â„¢s networks and connections between individuals that can provide support which is characterized by reciprocity, trustworthiness and resources. Individuals who are excluded from accessing social capital have a higher risk of schizophrenia and may have informal social control. Social functioning of individuals with schizophrenia gets disturbed therefore improving the functioning levels is considered to be an important goal in treating schizophrenia. Aim: To assess and compare personal social capital and socio-occupational functioning of patients with schizophrenia and normal controls. Materials and Methods: The sample consisted of 60 individuals (30 patients diagnosed with schizophrenia and 30 normal population) selected from the outpatient department (OPD) of the Central Institute of Psychiatry, Ranchi by using purposive sampling method. Positive and negative syndrome scale (for study group) and General health questionnaire (for normal population) applied for screening. Participants who fulfilled inclusion criteria were informed about study and consent was obtained. Socio-demographic and clinical datasheet, Personal Social Capital Scale and socio-occupational functioning scale were administered. Results: Present study shows a significant difference in personal social capital and socio-occupational functioning of persons with schizophrenia and normal controls.Â Conclusion: The patients with schizophrenia hold lower personal social capital and socio-occupational functioning than the normal population. Personal social capital and socio-occupational functioning showed a significant positive correlation, therefore, improvement in socio-occupational functioning can help to enhance personal social capital. Keywords: Schizophrenia, personal social capital, socio-occupational functioning

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RELATIONSHIP OF MATERNAL VITAMIN B12 STATUS IN PREGNANCY WITH PRETERM BIRTH AND MATERNAL HEALTH RISKS

International Medical Journal ◽

10.37436/2308-5274-2020-2-7 ◽

2020 ◽

pp. 32-38

Author(s):

VICTORIA LAZAROVA SPASOVA ◽

LILIA IVANOVA KOLEVA ◽

MARIETA ANTONOVA POPOVA ◽

VALENTINA BOYANOVA PETKOVA ◽

MILEN VENTZISLAVOV DIMITROV

Keyword(s):

Preterm Birth ◽

Vitamin B12 ◽

Pregnant Women ◽

Serum Vitamin ◽

Vitamin B12 Deficiency ◽

Inverse Association ◽

Maternal Vitamin ◽

B12 Deficiency ◽

The Impact ◽

In Pregnancy

Vitamin B12 is known to be vital for cell growth and population during pregnancy. This retrospective and prospective case−control study was aimed to disclose a health risk for pregnant women with vitamin B12 deficiency, as well as the one of the preterm birth. The main tasks set and performed in this research were as follows: to compare the obstetrics anamnesis between the women who gave birth on term and women who gave birth before term; to find the prevalence of vitamin B12 insufficiency in pregnancy; to determine its association with preterm birth and low birth weight; to examine its association with spontaneous abortions, and to investigate its relationship with obesity and hemoglobin levels in pregnant women. The conducted investigation involved 107 women who gave birth before the 37th week of gestation and 101 women who gave birth after the 37th week of gestation at the outpatient clinic of the University Hospital "Maichin Dom" in Bulgaria. Our study revealed a correlation between maternal vitamin B12 deficiency, overweight and low hemoglobin level. Our results showed no significant correlation between serum vitamin B12 level and the risk of preterm birth. However, we found an inverse association between vitamin B12 level and overweight before pregnancy and at the time of giving birth. As well there was confirmed the strong connection between meat consumption and vitamin B12 level. The paper emphasizes that the deficiency of the vitamin occurs most likely in the women with inadequate diets. Such a deficiency is actually confirmed to have serious health consequences for pregnant women and their offspring. Therefore further profound and numerous studies should be performed to properly assess the correlation between vitamin B12 and preterm birth, as well as to understand better the impact of vitamin B12 over pregnant women. Key words: vitamin B12, preterm birth, pregnancy, overweight, hemoglobin.

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Socioeconomic correlates and trends in smoking in pregnancy in New South Wales, Australia

Journal of Epidemiology & Community Health ◽

10.1136/jech.2009.104232 ◽

2010 ◽

Vol 65 (8) ◽

pp. 727-732 ◽

Cited By ~ 28

Author(s):

M. Mohsin ◽

A. E. Bauman ◽

R. Forero

Keyword(s):

New South ◽

New South Wales ◽

Smoking In Pregnancy ◽

South Wales ◽

In Pregnancy

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Neuropsychological Profiles of Children Following Vitamin B12 Deficiency During Infancy: A Case Series

Brain Impairment ◽

10.1017/brimp.2016.10 ◽

2016 ◽

Vol 17 (3) ◽

pp. 242-253

Author(s):

M. Greenham ◽

V. Anderson ◽

J. Campbell ◽

P. Monagle ◽

M.H. Beauchamp

Keyword(s):

Vitamin B12 ◽

Case Series ◽

Vitamin B12 Deficiency ◽

Brain Maturation ◽

Attention And Memory ◽

Long Term Outcomes ◽

Retrospective Case ◽

School Aged Children ◽

B12 Deficiency

Previous studies investigating long-term outcomes in children following vitamin B12 deficiency during infancy have been limited to IQ or clinical observation. This paper seeks to describe comprehensive neuropsychological profiles in a case series of school-aged children who were treated for infantile vitamin B12 deficiency. This was a retrospective case series of seven children who were treated for vitamin B12 deficiency during infancy and aged 5 to 16 years at the time of testing. While most children had age-expected intellectual performance, the distribution of the sample was skewed to the lower end of the normal range. Furthermore, children were found to have impairments in a number of neuropsychological domains, most common were attention and memory, followed by executive function. These results suggest that while neurological symptoms quickly resolve following treatment, these effects on early brain development may disrupt brain maturation and have the potential to impact on later development.

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