scholarly journals Sex differences in rates of change and burden of metabolic risk factors among adults who did and did not go on develop diabetes: two decades of follow-up from the Tehran Lipid and Glucose study

2020 ◽  
Author(s):  
Azra Ramezankhani ◽  
Fereidoun Azizi ◽  
Farzad Hadaegh
Keyword(s):  
Risk Factors ◽  
Rate Of Change ◽  
Activity Level ◽  
Metabolic Risk Factors ◽  
Individual Growth ◽  
Metabolic Risk ◽  
Family History Of Diabetes ◽  
P Values ◽  
Rates Of Change ◽  
Diabetes Status

<b>Objective:</b> We investigated the cumulative burden and linear rates of change of major metabolic risk factors (MRFs) among Iranian adults in whom type 2 diabetes did and did not develop. <p><b>Research Design and Methods:</b> We included 7,163 participants (3,069 men) aged 20-70 years at baseline with at least three examinations during 1999-2018. Individual growth curve modeling was used for data analysis. Statistical interactions for sex by diabetes status were adjusted for age, family history of diabetes, smoking status and physical activity level. </p> <p><b>Results:</b> Study sample included 743 (316 men) new cases of diabetes. In both men and women, compared with individuals in whom diabetes did not develop, individuals in whom diabetes developed had a higher burden of all MRFs and a greater rate of change in body mass index (BMI), fasting plasma glucose (FPG), systolic and diastolic blood pressure (SBP and DBP); however, the differences in burden and rate of change between those who did and did not develop diabetes were greater in women than in men. So that, during the transition to diabetes, women experienced more adverse change in BMI, FPG, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) (diabetes-sex interaction P values <0.05), and faster rates of change in BMI, FPG, HDL-C and total cholesterol (TC) (interaction P values <0.01) and SBP (interaction P=0.055) than men. </p> <p><b>Conclusion: </b>The greater exposure of women to and burden of MRFs before onset of diabetes may have implications for implementing sex specific strategies in order to prevent or delay diabetes complications.</p>

scholarly journals Sex differences in rates of change and burden of metabolic risk factors among adults who did and did not go on develop diabetes: two decades of follow-up from the Tehran Lipid and Glucose study

2020 ◽  
Author(s):  
Azra Ramezankhani ◽  
Fereidoun Azizi ◽  
Farzad Hadaegh
Keyword(s):  
Risk Factors ◽  
Rate Of Change ◽  
Activity Level ◽  
Metabolic Risk Factors ◽  
Individual Growth ◽  
Metabolic Risk ◽  
Family History Of Diabetes ◽  
P Values ◽  
Rates Of Change ◽  
Diabetes Status

<b>Objective:</b> We investigated the cumulative burden and linear rates of change of major metabolic risk factors (MRFs) among Iranian adults in whom type 2 diabetes did and did not develop. <p><b>Research Design and Methods:</b> We included 7,163 participants (3,069 men) aged 20-70 years at baseline with at least three examinations during 1999-2018. Individual growth curve modeling was used for data analysis. Statistical interactions for sex by diabetes status were adjusted for age, family history of diabetes, smoking status and physical activity level. </p> <p><b>Results:</b> Study sample included 743 (316 men) new cases of diabetes. In both men and women, compared with individuals in whom diabetes did not develop, individuals in whom diabetes developed had a higher burden of all MRFs and a greater rate of change in body mass index (BMI), fasting plasma glucose (FPG), systolic and diastolic blood pressure (SBP and DBP); however, the differences in burden and rate of change between those who did and did not develop diabetes were greater in women than in men. So that, during the transition to diabetes, women experienced more adverse change in BMI, FPG, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) (diabetes-sex interaction P values <0.05), and faster rates of change in BMI, FPG, HDL-C and total cholesterol (TC) (interaction P values <0.01) and SBP (interaction P=0.055) than men. </p> <p><b>Conclusion: </b>The greater exposure of women to and burden of MRFs before onset of diabetes may have implications for implementing sex specific strategies in order to prevent or delay diabetes complications.</p>

The influence of family history of diabetes on disease prevalence and associated metabolic risk factors among Sri Lankan adults

2014 ◽  
Vol 32 (3) ◽  
pp. 314-323 ◽  
Author(s):  
P. Katulanda ◽  
P. Ranasinghe ◽  
R. Jayawardena ◽  
R. Sheriff ◽  
D. R. Matthews
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Disease Prevalence ◽  
Metabolic Risk Factors ◽  
Sri Lankan ◽  
Metabolic Risk ◽  
Family History Of Diabetes ◽  
History Of

scholarly journals Accuracy of food intake reporting in obese subjects with metabolic risk factors

2006 ◽  
Vol 95 (3) ◽  
pp. 640-649 ◽  
Author(s):  
Mette Svendsen ◽  
Serena Tonstad
Keyword(s):  
Risk Factors ◽  
Energy Density ◽  
Energy Expenditure ◽  
Total Energy ◽  
Dietary Restraint ◽  
Total Energy Expenditure ◽  
Activity Level ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Obese Subjects

The aim of the present study was to determine the accuracy of reported energy intake according to a food-frequency questionnaire (FFQ) and dietary records (DR) in obese subjects with metabolic syndrome risk factors. Subjects were twenty-three men and twenty-seven women with mean BMI of 35·7 (range 30·5–43·8) kg/m2 who participated in a dietary interview based on a FFQ and completed weighed DR. Total energy expenditure was measured with the doubly labelled water method. Total energy expenditure, measured RMR and physical activity level did not differ between under-reporters (50% of the sample) and non-under-reporters. Under-reporters had lower median intake of sweets, desserts and snacks than non-under-reporters (100 V.. 161g/d (P=0·0008) and 61 V.. 128g/d (P.=0·0002) according to the FFQ and DR, respectively). The DR also showed lower energy density (6·7 (sd 1·3) V 7·9 (sd 1·6) kJ/g; P=0·0064), lower intake of sugary drinks (0 V. 167g/d; P=0·0063) and higher scores for dietary restraint (9·0 (sd 5·0) V. 6·1 (sd 3·5); P=0·0285) in under-reporters. Energy density was associated with accuracy according to the FFQ (Spearman's rank correlation coefficient (RS) 0·406; P=0·0034) and the DR (RS 0·537; P<0·0001). In multivariate analysis, consumption of bread and sweets, desserts and snacks measured by the FFQ was positively associated with accuracy (I2adjusted 0·46 (95% CI 0·32, 0·70)). According to the DR, consumption of sweets, desserts and snacks was also associated with accuracy, as was dietary restraint (inversely) (I2adjusted 0·67 (95% CI 0·54, 0·83)). In obese subjects with metabolic risk factors, intake of sweets, desserts and snacks, bread and dietary restraint were determinants of reporting accuracy.

scholarly journals Accelerometer-based measures of sedentary behavior and cardio-metabolic risk in active older adults

2014 ◽  
Vol 37 (2) ◽  
pp. 108 ◽  
Author(s):  
Jocelyn M Chase ◽  
Christine K Lockhart ◽  
Maureen C Ashe ◽  
Kenneth M Madden
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Sedentary Behavior ◽  
Sedentary Time ◽  
Density Lipoprotein ◽  
Activity Level ◽  
Metabolic Risk Factors ◽  
Metabolic Effects ◽  
Metabolic Risk ◽  
Physically Active

Purpose: Sedentary behavior has been proposed as an independent cardio-metabolic risk factor even in adults who are physically active through recreational activity. Because little is known about the metabolic effects of sedentariness in seniors, the relationship between sedentary behavior and cardio-metabolic risk was examined in physically active older adults. Methods: Fifty-four community dwelling men and women > 65 years of age (mean 71.5 years) were enrolled in this cross-sectional observational study. Subjects were in good health and free of known diabetes. Activity levels (sedentary, light, moderate to vigorous activity time per day) were recorded with accelerometers worn continuously for 7 days. Cardio-metabolic risk factors measured consisted of the American Heart Association diagnostic criteria for metabolic syndrome (waist circumference, triglycerides, high-density lipoprotein, systolic blood pressure and fasting glucose) as well as low-density lipoprotein (LDL). The relationships between activity measures and cardio-metabolic risk factors were examined. Significant variables were then entered into a stepwise multivariate regression model. Results: All but one subject achieved exercise levels recommended by the American College of Sports Medicine. The average proportion of time spent at a sedentary activity level each day was 72.7%. From the regression analysis, the only significant association found between cardio-metabolic risk outcomes and activity predictors was between LDL and sedentary time, with LDL detrimentally associated with average sedentary time per day (Standardized Beta Correlation Coefficient 0.302, p < 0.05). Conclusion: Sedentary behavior is associated with an adverse metabolic effect on LDL in seniors, even those who meet guideline recommendations for an active “fit” adult.

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

2020 ◽  
Vol 29 (2) ◽  
pp. 175-179
Author(s):  
Melania Macarie ◽  
Simona Bataga ◽  
Simona Mocan ◽  
Monica Pantea ◽  
Razvan Opaschi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Statistical Significance ◽  
Interval Cancer ◽  
Metabolic Risk Factors ◽  
Control Group ◽  
Anatomical Site ◽  
Metabolic Risk ◽  
Right Colon ◽  
Serrated Lesions ◽  
The Right

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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