scholarly journals Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study

Diabetes Care ◽  
2021 ◽  
pp. dc202839
Author(s):  
Robin Kristófi ◽  
Johan Bodegard ◽  
Anna Norhammar ◽  
Marcus Thuresson ◽  
David Nathanson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Observational Study ◽  
Renal Disease ◽  
Disease Burden ◽  
Nationwide Observational Study

scholarly journals Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study

2021 ◽  
Author(s):  
Robin Kristófi ◽  
Johan Bodegard ◽  
Anna Norhammar ◽  
Marcus Thuresson ◽  
David Nathanson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Renal Disease ◽  
Cox Regression ◽  
Cardiovascular Death ◽  
Nationwide Observational Study ◽  
Event Rates ◽  
Design And Methods

<b>Objective: </b>Type 1 (T1D) and type 2 diabetes (T2D) increase risks of cardiovascular and renal disease (CVRD) compared to diabetes-free populations. Direct comparisons between T1D and T2D are scarce. We examined this by pooling full-population cohorts in Sweden and Norway. <p><b>Research Design and Methods: </b>59,331 T1D and 484,241 T2D patients, aged 18-84 years, were followed over a mean period of 2.6 years from December 31, 2013. Patients were identified in nationwide prescribed drug and hospital registries in Norway and Sweden<b>. </b>Prevalence and event rates of myocardial infarction (MI), heart failure (HF), stroke, chronic kidney disease (CKD), all-cause death and cardiovascular death were assessed following age stratification in 5-year intervals. Cox regression analyses were used to estimate risk.</p> <p><b>Results: </b>The prevalence of cardiovascular disease was similar in T1D and T2D across age strata, whereas CKD was more common in T1D. Age-adjusted event-rates comparing T1D versus T2D showed that HF risk was increased between the ages 65-79 years, MI between 55-79 years and stroke between 40-54 years, 1.3-1.4-fold, 1.3-1.8-fold and 1.4-1.7 fold respectively. CKD risk was 1.4-3.0-fold higher in T1D at all ages. The all-cause death risk was 1.2-1.5-fold higher in T1D above 50 years, with a similar trend for CV death.</p> <p><b>Conclusions: </b>Adult T1D compared to T2D patients had an overall greater risk of cardiorenal disease (heart failure and CKD) across ages, of MI and all-cause death at middle-older ages and of stroke at younger ages. The total age-adjusted CVRD burden and risks were greater among T1D patients compared to T2D, highlighting their need for improved prevention strategies.</p>

scholarly journals Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study

2021 ◽  
Author(s):  
Robin Kristófi ◽  
Johan Bodegard ◽  
Anna Norhammar ◽  
Marcus Thuresson ◽  
David Nathanson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Renal Disease ◽  
Cox Regression ◽  
Cardiovascular Death ◽  
Nationwide Observational Study ◽  
Event Rates ◽  
Design And Methods

<b>Objective: </b>Type 1 (T1D) and type 2 diabetes (T2D) increase risks of cardiovascular and renal disease (CVRD) compared to diabetes-free populations. Direct comparisons between T1D and T2D are scarce. We examined this by pooling full-population cohorts in Sweden and Norway. <p><b>Research Design and Methods: </b>59,331 T1D and 484,241 T2D patients, aged 18-84 years, were followed over a mean period of 2.6 years from December 31, 2013. Patients were identified in nationwide prescribed drug and hospital registries in Norway and Sweden<b>. </b>Prevalence and event rates of myocardial infarction (MI), heart failure (HF), stroke, chronic kidney disease (CKD), all-cause death and cardiovascular death were assessed following age stratification in 5-year intervals. Cox regression analyses were used to estimate risk.</p> <p><b>Results: </b>The prevalence of cardiovascular disease was similar in T1D and T2D across age strata, whereas CKD was more common in T1D. Age-adjusted event-rates comparing T1D versus T2D showed that HF risk was increased between the ages 65-79 years, MI between 55-79 years and stroke between 40-54 years, 1.3-1.4-fold, 1.3-1.8-fold and 1.4-1.7 fold respectively. CKD risk was 1.4-3.0-fold higher in T1D at all ages. The all-cause death risk was 1.2-1.5-fold higher in T1D above 50 years, with a similar trend for CV death.</p> <p><b>Conclusions: </b>Adult T1D compared to T2D patients had an overall greater risk of cardiorenal disease (heart failure and CKD) across ages, of MI and all-cause death at middle-older ages and of stroke at younger ages. The total age-adjusted CVRD burden and risks were greater among T1D patients compared to T2D, highlighting their need for improved prevention strategies.</p>

scholarly journals Perspectives of Patients with Insulin-Treated Type 1 and Type 2 Diabetes on Hypoglycemia: Results of the HAT Observational Study in Central and Eastern European Countries

2018 ◽  
Vol 9 (2) ◽  
pp. 727-741 ◽  
Author(s):  
Martin Haluzik ◽  
Adam Kretowski ◽  
Krzysztof Strojek ◽  
Leszek Czupryniak ◽  
Andrej Janez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Observational Study ◽  
European Countries ◽  
Eastern European ◽  
Eastern European Countries

Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. Results of the Hypos-1 observational study

2019 ◽  
Vol 29 (7) ◽  
pp. 736-743 ◽  
Author(s):  
Maria Chiara Rossi ◽  
Antonio Nicolucci ◽  
Alessandro Ozzello ◽  
Sandro Gentile ◽  
Alberto Aglialoro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Observational Study ◽  
Fear Of Hypoglycemia
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