Presence and Determinants of Cardiovascular Disease and Mortality in Individuals With Type 1 Diabetes of Long Duration: The FinnDiane 50 Years of Diabetes Study

Diabetes Care ◽  
2021 ◽  
pp. dc202816
Author(s):  
Valma Harjutsalo ◽  
Drazenka Pongrac Barlovic ◽  
Daniel Gordin ◽  
Carol Forsblom ◽  
George King ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Long Duration

scholarly journals Presence and Determinants of Cardiovascular Disease and Mortality in Individuals With Type 1 Diabetes of Long Duration: The FinnDiane 50 Years of Diabetes Study

2021 ◽  
Author(s):  
Valma Harjutsalo ◽  
Drazenka Pongrac Barlovic ◽  
Daniel Gordin ◽  
Carol Forsblom ◽  
George King ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Cumulative Incidence ◽  
Diabetes Duration ◽  
Baseline Visit ◽  
Background Population ◽  
Long Duration

<b>Objective</b> <p>The aim of this study was to determine the incidence of cardiovascular disease (CVD) and mortality as well as their risk factors in type 1 diabetes (T1D) with more than 50-years duration. </p> <p><b>Methods</b><b></b></p> <p>From 5,396 individuals included in the Finnish Diabetic Nephropathy Study, 729 diagnosed in 1967 or earlier survived with T1D for more than 50 years. In this FinnDiane 50-year cohort, cumulative incidence of CVD events was assessed from the diagnosis of diabetes, and the excess CVD risk, compared to matched 12,710 individuals without diabetes, was calculated by Fine and Gray’s method. In addition, at the baseline visit (median duration of diabetes of 39 years) risk factors for different types of CVD (both non-fatal and fatal) and mortality were analyzed and cause-specific hazard ratios were estimated during a median follow-up of 16.6 years from the baseline visit. </p> <p><b>Results</b> </p> <p>In individuals with diabetes duration of more than 50 years, the 60-year cumulative incidence of CVD from the diagnosis of diabetes was 64.3% (62.5-66.0). Compared to individuals without diabetes, the standardized incidence ratio for CVD was 7.4 (6.5-8.3) and was in persons with normoalbuminuria 4.9 (4.0-5.9). Mean HbA<sub>1c</sub> and HbA<sub>1c</sub> variability, dyslipidemia, BMI, kidney disease, age and diabetes duration were the variables associated with incident CVD. In particular, HbA<sub>1c </sub>was associated with peripheral artery disease (PAD). Standardized mortality ratio compared with the Finnish background population was 3.2 (2.8-3.7). The factors, associated with mortality were diabetes duration, increased HbA<sub>1c</sub> variability, inflammation, insulin resistance, kidney disease and PAD.</p> <p><b> </b></p> <p><b>Conclusions</b></p> <p>Individuals with T1D of very long duration are at a high risk of CVD. In addition, throughout the lifespan, optimal glycemic control remains central to CVD and excess mortality prevention. </p>

scholarly journals Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes

Diabetes Care ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 815-822 ◽  
Author(s):  
Daniel Gordin ◽  
Valma Harjutsalo ◽  
Liane Tinsley ◽  
Ward Fickweiler ◽  
Jennifer K. Sun ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Differential Association ◽  
Long Duration

scholarly journals Cardiovascular Disease Protection in Long-Duration Type 1 Diabetes and Sex Differences

Diabetes Care ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. e73-e74 ◽  
Author(s):  
Zhiheng H. He ◽  
Stephanie A. D’Eon ◽  
Liane J. Tinsley ◽  
Shane Fitzgerald ◽  
Stephanie M. Hastings ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Sex Differences ◽  
Long Duration

scholarly journals Presence and Determinants of Cardiovascular Disease and Mortality in Individuals With Type 1 Diabetes of Long Duration: The FinnDiane 50 Years of Diabetes Study

2021 ◽  
Author(s):  
Valma Harjutsalo ◽  
Drazenka Pongrac Barlovic ◽  
Daniel Gordin ◽  
Carol Forsblom ◽  
George King ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Kidney Disease ◽  
Cumulative Incidence ◽  
Diabetes Duration ◽  
Baseline Visit ◽  
Background Population ◽  
Long Duration

<b>Objective</b> <p>The aim of this study was to determine the incidence of cardiovascular disease (CVD) and mortality as well as their risk factors in type 1 diabetes (T1D) with more than 50-years duration. </p> <p><b>Methods</b><b></b></p> <p>From 5,396 individuals included in the Finnish Diabetic Nephropathy Study, 729 diagnosed in 1967 or earlier survived with T1D for more than 50 years. In this FinnDiane 50-year cohort, cumulative incidence of CVD events was assessed from the diagnosis of diabetes, and the excess CVD risk, compared to matched 12,710 individuals without diabetes, was calculated by Fine and Gray’s method. In addition, at the baseline visit (median duration of diabetes of 39 years) risk factors for different types of CVD (both non-fatal and fatal) and mortality were analyzed and cause-specific hazard ratios were estimated during a median follow-up of 16.6 years from the baseline visit. </p> <p><b>Results</b> </p> <p>In individuals with diabetes duration of more than 50 years, the 60-year cumulative incidence of CVD from the diagnosis of diabetes was 64.3% (62.5-66.0). Compared to individuals without diabetes, the standardized incidence ratio for CVD was 7.4 (6.5-8.3) and was in persons with normoalbuminuria 4.9 (4.0-5.9). Mean HbA<sub>1c</sub> and HbA<sub>1c</sub> variability, dyslipidemia, BMI, kidney disease, age and diabetes duration were the variables associated with incident CVD. In particular, HbA<sub>1c </sub>was associated with peripheral artery disease (PAD). Standardized mortality ratio compared with the Finnish background population was 3.2 (2.8-3.7). The factors, associated with mortality were diabetes duration, increased HbA<sub>1c</sub> variability, inflammation, insulin resistance, kidney disease and PAD.</p> <p><b> </b></p> <p><b>Conclusions</b></p> <p>Individuals with T1D of very long duration are at a high risk of CVD. In addition, throughout the lifespan, optimal glycemic control remains central to CVD and excess mortality prevention. </p>

scholarly journals Comment on Gordin et al. Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 2018;41:815–822

Diabetes Care ◽  
2018 ◽  
Vol 41 (7) ◽  
pp. e127-e127 ◽  
Author(s):  
Marie Azar ◽  
Elise Coirier ◽  
Marie-Noelle Delyfer ◽  
Jean-François Korobelnik ◽  
Kamel Mohammedi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Diabetes Care ◽  
Differential Association ◽  
Long Duration

407-P: Cardiac and Retinal Imaging Studies Suggest Comparable Protective Factors between Cardiovascular Disease and Retinopathy in Long Duration Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 407-P
Author(s):  
MARC GREGORY YU ◽  
HETAL SHAH ◽  
EMILY WOLFSON ◽  
VANESSA BAHNAM ◽  
JOHN GAUTHIER ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Protective Factors ◽  
Retinal Imaging ◽  
Imaging Studies ◽  
Long Duration

Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 15-LB
Author(s):  
SANJEEV N. MEHTA ◽  
MENGDI WU ◽  
NICOLE C. FOSTER ◽  
RODICA POP-BUSUI ◽  
MICHELLE KATZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Type 1 Diabetes
Sign in / Sign up

Export Citation Format

Share Document