scholarly journals Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes

Diabetes Care ◽  
2021 ◽  
Vol 44 (3) ◽  
pp. 655-662
Author(s):  
Laili Soleimani ◽  
Ramit Ravona-Springer ◽  
Hung-Mo Lin ◽  
Xiaoyu Liu ◽  
Mary Sano ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline

scholarly journals Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes

2021 ◽  
Author(s):  
Laili Soleimani ◽  
Ramit Ravona-Springer ◽  
Hung-Mo Lin ◽  
Xiaoyu Liu ◽  
Mary Sano ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Random Coefficients ◽  
Neuropsychological Battery ◽  
Five Dimensions

Objective: Depression is highly frequent in older adults with Type 2 Diabetes and is associated with cognitive impairment. Yet, little is known about how various depression dimensions differentially affect cognition. We investigated longitudinal associations of specific depression dimensions with cognitive decline. <p> </p> <p>Research Design and Methods: Participants (N=1002) were from the Israel Diabetes and Cognitive Decline study, 65+ years of age with Type 2 Diabetes, not demented at baseline. Participants underwent comprehensive neuropsychological battery at baseline and every 18 months thereafter including domains of Episodic Memory, Attention/Working Memory, Semantic Categorization/Language, Executive Function and Z scores of each domain were averaged and further normalized to calculate Global Cognition. Depression items from Geriatric Depression Scale- 15 items (GDS-15) was measured at each visit and subcategorized to five dimensions: Dysphoric Mood, Withdrawal Apathy-Vigor (entitled apathy), Anxiety, Hopelessness and Memory complaint. Random coefficients models examined association of depression dimensions with baseline and longitudinal cognitive functioning adjusting for socio-demographics and baseline characteristics, including cardiovascular risk factors, physical activity and use of diabetic medications. </p> <p> </p> <p>Result: In the fully adjusted model, at baseline, all dimensions of depression, except for anxiety, were associated with some aspects of cognition (p-values from .01 to <.001). Longitudinally, greater apathy scores were associated with faster decline in executive functions (p=.004), a results that withstood adjustment for multiple comparisons. Associations of other depression dimensions with cognitive decline were not significant (p>0.01).</p> <p> </p> <p>Conclusion: Apathy was associated with a faster cognitive decline in executive functions. These findings highlight the heterogeneity of depression as a clinical construct rather than a single entity and point to apathy as a specific risk factor for cognitive decline among older adults with Type 2 Diabetes. </p>

scholarly journals Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (11) ◽  
pp. 2691-2701
Author(s):  
Katherine Samaras ◽  
Steve Makkar ◽  
John D. Crawford ◽  
Nicole A. Kochan ◽  
Wei Wen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline ◽  
Incident Dementia ◽  
Ageing Study

Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults

2008 ◽  
Vol 56 (6) ◽  
pp. 1028-1036 ◽  
Author(s):  
Olivia I. Okereke ◽  
Jae H. Kang ◽  
Nancy R. Cook ◽  
J. Michael Gaziano ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Decline ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Comment on Samara et al. Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study. Diabetes Care 2020;43:2691–2701

Diabetes Care ◽  
2021 ◽  
Vol 44 (4) ◽  
pp. e73-e73
Author(s):  
Jorge Rafael Violante-Cumpa ◽  
Luis Alberto Pérez-Arredondo ◽  
José Gerardo González-González ◽  
Leonardo Guadalupe Mancillas-Adame
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline ◽  
Diabetes Care ◽  
Incident Dementia ◽  
Ageing Study

scholarly journals Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes

2021 ◽  
Author(s):  
Laili Soleimani ◽  
Ramit Ravona-Springer ◽  
Hung-Mo Lin ◽  
Xiaoyu Liu ◽  
Mary Sano ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Random Coefficients ◽  
Neuropsychological Battery ◽  
Five Dimensions

Objective: Depression is highly frequent in older adults with Type 2 Diabetes and is associated with cognitive impairment. Yet, little is known about how various depression dimensions differentially affect cognition. We investigated longitudinal associations of specific depression dimensions with cognitive decline. <p> </p> <p>Research Design and Methods: Participants (N=1002) were from the Israel Diabetes and Cognitive Decline study, 65+ years of age with Type 2 Diabetes, not demented at baseline. Participants underwent comprehensive neuropsychological battery at baseline and every 18 months thereafter including domains of Episodic Memory, Attention/Working Memory, Semantic Categorization/Language, Executive Function and Z scores of each domain were averaged and further normalized to calculate Global Cognition. Depression items from Geriatric Depression Scale- 15 items (GDS-15) was measured at each visit and subcategorized to five dimensions: Dysphoric Mood, Withdrawal Apathy-Vigor (entitled apathy), Anxiety, Hopelessness and Memory complaint. Random coefficients models examined association of depression dimensions with baseline and longitudinal cognitive functioning adjusting for socio-demographics and baseline characteristics, including cardiovascular risk factors, physical activity and use of diabetic medications. </p> <p> </p> <p>Result: In the fully adjusted model, at baseline, all dimensions of depression, except for anxiety, were associated with some aspects of cognition (p-values from .01 to <.001). Longitudinally, greater apathy scores were associated with faster decline in executive functions (p=.004), a results that withstood adjustment for multiple comparisons. Associations of other depression dimensions with cognitive decline were not significant (p>0.01).</p> <p> </p> <p>Conclusion: Apathy was associated with a faster cognitive decline in executive functions. These findings highlight the heterogeneity of depression as a clinical construct rather than a single entity and point to apathy as a specific risk factor for cognitive decline among older adults with Type 2 Diabetes. </p>

scholarly journals Consumption of ultra‐processed food and cognitive decline among older adults with type‐2 diabetes

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Galit Weinstein ◽  
Shiraz Vered ◽  
Dana Ivancovsky‐Wajcman ◽  
Shira Zelber‐Sagi ◽  
Ramit Ravona‐Springer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline ◽  
Processed Food

scholarly journals The COMT rs4680 polymorphism is associated with rate of cognitive decline in older adults with type 2 diabetes

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Sigalit Manzali ◽  
Michal Schnaider Beeri ◽  
Ramit Ravona‐Springer ◽  
HungMo Lin ◽  
Xiaoyu Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline

DETERIORATION IN MOTOR FUNCTION OVER TIME IN OLDER ADULTS WITH TYPE 2 DIABETES IS ASSOCIATED WITH ACCELERATED COGNITIVE DECLINE

2020 ◽  
Vol 26 (10) ◽  
pp. 1143-1152
Author(s):  
Ithamar Ganmore ◽  
Isak Elkayam ◽  
Ramit Ravona-Springer ◽  
Hung-Mo Lin ◽  
Xiaoyu Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Decline ◽  
Motor Function ◽  
Gait Speed ◽  
Semantic Categorization ◽  
Z Scores ◽  
Global Cognition ◽  
Rate Of Decline

Objective: Type 2 diabetes (T2D) is associated with motor impairments and a higher dementia risk. The relationships of motor decline with cognitive decline in T2D older adults has rarely been studied. Using data from the Israel Diabetes and Cognitive Decline study (N = 892), we examined associations of decline in motor function with cognitive decline over a 54-month period. Methods: Motor function measures were strength (handgrip) and gait speed (time to walk 3 m). Participants completed a neuropsychologic battery of 13 tests transformed into z-scores, summarized into 4 cognitive domains: episodic memory, attention/working memory, executive functions, and language/semantic categorization. The average of the 4 domains’ z-scores defined global cognition. Motor and cognitive functions were assessed in 18-months intervals. A random coefficients model delineated longitudinal relationships of cognitive decline with baseline and change from baseline in motor function, adjusting for sociodemographic, cardiovascular, and T2D-related covariates. Results: Slower baseline gait speed levels were significantly associated with more rapid decline in global cognition ( P = .004), language/semantic categorization ( P = .006) and episodic memory ( P = .029). Greater decline over time in gait speed was associated with an accelerated rate of decline in global cognition ( P = .050), attention/working memory ( P = .047) and language/semantic categorization ( P<.001). Baseline strength levels were not associated with cognitive decline but the rate of declining strength was associated with an accelerated decline in executive functions ( P = .025) and language/semantic categorization ( P = .006). Conclusion: In T2D older adults, the rate of decline in motor function, beyond baseline levels, was associated with accelerated cognitive decline, suggesting that cognitive and motor decline share common neuropathologic mechanisms in T2D. Abbreviations: HbA1c = hemoglobin A1c; IDCD = Israel Diabetes and Cognitive Decline; T2D = type 2 diabetes

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