scholarly journals Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials

Diabetes Care ◽  
2021 ◽  
Vol 44 (2) ◽  
pp. 618-630
Author(s):  
Shaun A. Mason ◽  
Michelle A. Keske ◽  
Glenn D. Wadley
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Glycemic Control ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Vitamin C Supplementation

scholarly journals Effect of Oats and Oat-Fiber on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 489-489
Author(s):  
Victoria Chen ◽  
Andreea Zurbau ◽  
Amna Ahmed ◽  
Tauseef Khan ◽  
Cyril Kendall ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Randomized Controlled Trials ◽  
Plasma Glucose ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Controlled Trials ◽  
Randomized Controlled

Abstract Objectives Current approved health claims in Canada, US and Europe recognize the ability of oat ß-glucan to lower blood cholesterol; however, its ability to improve glycemic control is less certain. We undertook a systematic review and meta-analysis of randomized controlled trials to update the evidence of the effect of oats and oat-fiber on markers of glycemic control in people with and without diabetes. Here we present data for the subgroup with diabetes. Methods MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched through September 23rd, 2020. We included randomized controlled trials of ≥ 2-weeks of sources of oat ß-glucan and measures of glycemic control in diabetes. Two independent reviewers extracted relevant data and assessed the risk of bias (Cochrane Risk of Bias 2.0 Tool). The outcomes were fasting plasma glucose (FPG), 2h-plasma glucose (2h-PG) from a 75 g-oral glucose tolerance test, HbA1c and fasting plasma insulin (FPI). Data were pooled using the generic inverse variance method. Heterogeneity was assessed (Cochran Q statistic) and quantified (I2 statistic). Pooled estimates were expressed as mean differences with 95% confidence intervals (CI). GRADE assessed the certainty of the evidence. Results Eligibility criteria were met by 5 trial comparisons (N = 359) in type 2 diabetes. No trials were identified in type 1 diabetes. Consumption of oat ß-glucan sources reduced FPG (MD = −0.37 mmol/L [95% CI: −0.70, −0.05 mmol/L], P = 0.03, I2 = 0.00%, PQ = 0.76) and 2h-PG (MD = −1.24 mmol/L [95% CI: −1.97, −0.51 mmol/L], P = 0.00, I2 = 0.00%, PQ = 0.56). There were non-significant reductions in HbA1c (MD = −0.12%, [95% CI: −0.26, 0.01%], P = 0.07, I2 = 0.00%, PQ = 1.00) and FPI (MD = −4.59 pmol/L, [95% CI: −14.71, 5.52 pmol/L], P = 0.37, I2 = 40.84%, PQ = 0.19). The certainty of evidence was high for 2h-PG and moderate for FPG, HbA1c and FPI (single downgrades for imprecision in each case). Conclusions Current evidence provides a good indication that consumption of oat ß-glucan results in small improvements of glycemic control in type 2 diabetes. More high quality randomized trials are required to improve the precision of the pooled estimates. (ClinicalTrials.gov identifier, NCT04631913) Funding Sources Quaker Oats Center of Excellence, Diabetes Canada, Banting & Best Diabetes Centre, Toronto 3D foundation

scholarly journals Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials

2021 ◽  
Author(s):  
Shaun A Mason ◽  
Michelle A Keske ◽  
Glenn D Wadley
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Vitamin C ◽  
Controlled Trials ◽  
Short Term ◽  
Randomized Controlled ◽  
Vitamin C Supplementation

<a><b>BACKGROUND </b></a>Evidence suggests vitamin C supplementation could be a potential therapy in type 2 diabetes. However, its effectiveness and evidence quality require further evaluation. <p><b>PURPOSE</b> To investigate the efficacy of oral vitamin C supplementation in improving glycemic control, cardiovascular risk factors, and oxidative stress in people with type 2 diabetes.</p> <p><b>DATA SOURCES</b> Databases (PubMed, Embase, Scopus, Cochrane Library) and clinical trial registries were searched for randomized controlled trials up to 09/08/2020. </p> <p><b>STUDY SELECTION</b> Trials in adults with type 2 diabetes were included. Trials were excluded if supplements were not exclusive to vitamin C, and if <2 weeks in duration. </p> <p><b>DATA EXTRACTION</b> Primary outcomes were HbA1c, glucose, cholesterol, triglycerides, and blood pressure (BP). Data were extracted for changes in outcomes between vitamin C and control groups. Evidence certainty was assessed using GRADE methods. </p> <p><b>DATA SYNTHESIS</b> Twenty-eight studies (n=1574) were included in the review. Outcomes changed to a statistically and clinically significant extent with Vitamin C were systolic BP (mean difference [MD] −6.27, 95% CI [−9.60, −2.96] mmHg; p=0.0002) with moderate evidence certainty; and HbA1c (MD −0.54 [−0.90, −0.17] %; p=0.004) and diastolic BP (MD −3.77 [−6.13, −1.42] mmHg; p=0.002) with very low evidence certainty. </p> <p><b>LIMITATIONS</b> Studies were predominantly short-term (<6 months) with a small number of participants (n<100).</p> <a><b>CONCLUSION</b> While evidence from short-term studies suggests vitamin C supplementation may improve glycemic control and blood pressure in people with type 2 diabetes, vitamin C supplementation cannot currently be recommended as a therapy until larger, long-term and high quality trials confirm these findings. </a>

Fiber intake and glycemic control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of randomized controlled trials

2013 ◽  
Vol 71 (12) ◽  
pp. 790-801 ◽  
Author(s):  
Flávia M Silva ◽  
Caroline K Kramer ◽  
Jussara C de Almeida ◽  
Thais Steemburgo ◽  
Jorge Luiz Gross ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Fiber Intake ◽  
Randomized Controlled
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