scholarly journals Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study

Diabetes Care ◽  
2020 ◽  
pp. dc201463
Author(s):  
Josefin E. Löfvenborg ◽  
Sofia Carlsson ◽  
Tomas Andersson ◽  
Christiane S. Hampe ◽  
Albert Koulman ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Plasma Phospholipid ◽  
Fish Intake ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Dietary Fish ◽  
Adult Onset Diabetes ◽  
Gad65 Antibodies

scholarly journals Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study

2020 ◽  
Author(s):  
Josefin E Löfvenborg ◽  
Sofia Carlsson ◽  
Tomas Andersson ◽  
Christiane S Hampe ◽  
Albert Koulman ◽  
...  
Keyword(s):  
Plasma Phospholipid ◽  
Fish Intake ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Dietary Fish ◽  
Antibody Positivity ◽  
Adult Onset Diabetes ◽  
Gad65 Antibody ◽  
High Fish ◽  
Gad65 Antibodies

<b><i>Objective:</i></b> Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid polyunsaturated omega-3 fatty acid (n-3 PUFA) concentration with GAD65 antibody positivity on the risk of developing adult onset diabetes. <p><b><i>Research Design and Methods:</i></b> We used prospective data on 11,247 incident cases of adult onset diabetes and 14,288 non-cases from the EPIC-InterAct case-cohort study, conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction; AP) and multiplicative interaction between GAD65 antibody positivity (≥65 U/ml) and low fish/n-3 PUFA were assessed.</p> <p><b><i>Results:</i></b> The hazard of diabetes in antibody positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52, 95% CI 1.76-3.63; 2.48, 1.79-3.45) compared to people who were GAD65 antibody negative and had high fish intake, with evidence of additive (AP 0.44, 95% CI 0.16-0.72; 0.48, 0.24-0.72) and multiplicative (p=0.0465; 0.0103) interaction. Individuals with high GAD65 antibody levels (≥167.5 U/ml) and low total plasma phospholipid n-3 PUFA had more than 4-fold higher hazard of diabetes (HR 4.26, 2.70-6.72), AP 0.46 (0.12-0.80), compared to antibody negative individuals with high n-3 PUFA. </p> <b><i>Conclusions:</i></b> High fish intake or relative plasma phospholipid n-3 PUFA concentrations may partially counteract the increased diabetes risk conferred by GAD65 antibody positivity.

scholarly journals Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study

2020 ◽  
Author(s):  
Josefin E Löfvenborg ◽  
Sofia Carlsson ◽  
Tomas Andersson ◽  
Christiane S Hampe ◽  
Albert Koulman ◽  
...  
Keyword(s):  
Plasma Phospholipid ◽  
Fish Intake ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Dietary Fish ◽  
Antibody Positivity ◽  
Adult Onset Diabetes ◽  
Gad65 Antibody ◽  
High Fish ◽  
Gad65 Antibodies

<b><i>Objective:</i></b> Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid polyunsaturated omega-3 fatty acid (n-3 PUFA) concentration with GAD65 antibody positivity on the risk of developing adult onset diabetes. <p><b><i>Research Design and Methods:</i></b> We used prospective data on 11,247 incident cases of adult onset diabetes and 14,288 non-cases from the EPIC-InterAct case-cohort study, conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction; AP) and multiplicative interaction between GAD65 antibody positivity (≥65 U/ml) and low fish/n-3 PUFA were assessed.</p> <p><b><i>Results:</i></b> The hazard of diabetes in antibody positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52, 95% CI 1.76-3.63; 2.48, 1.79-3.45) compared to people who were GAD65 antibody negative and had high fish intake, with evidence of additive (AP 0.44, 95% CI 0.16-0.72; 0.48, 0.24-0.72) and multiplicative (p=0.0465; 0.0103) interaction. Individuals with high GAD65 antibody levels (≥167.5 U/ml) and low total plasma phospholipid n-3 PUFA had more than 4-fold higher hazard of diabetes (HR 4.26, 2.70-6.72), AP 0.46 (0.12-0.80), compared to antibody negative individuals with high n-3 PUFA. </p> <b><i>Conclusions:</i></b> High fish intake or relative plasma phospholipid n-3 PUFA concentrations may partially counteract the increased diabetes risk conferred by GAD65 antibody positivity.

Novel clusters of adult-onset Diabetes: Casuistic from an Endocrinology Department

2019 ◽  
Author(s):  
Vitoria Duarte ◽  
Catarina Ivo ◽  
David Verissimo ◽  
Joao Silva ◽  
Luis Lopes ◽  
...  
Keyword(s):  
Adult Onset ◽  
Onset Diabetes ◽  
Adult Onset Diabetes

scholarly journals Case report: adult onset diabetes with partial pancreatic agenesis and congenital heart disease due to a de novo GATA6 mutation

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Begona Sanchez-Lechuga ◽  
Muhammad Saqlain ◽  
Nicholas Ng ◽  
Kevin Colclough ◽  
Conor Woods ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Case Report ◽  
Congenital Heart ◽  
De Novo ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Adult Onset Diabetes ◽  
Pancreatic Agenesis

Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: Relation with fish intake, circulating biomarkers, and mortality

2013 ◽  
Vol 165 (2) ◽  
pp. 208-215.e4 ◽  
Author(s):  
Serge Masson ◽  
Roberto Marchioli ◽  
Dariush Mozaffarian ◽  
Roberto Bernasconi ◽  
Valentina Milani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acids ◽  
Chronic Heart Failure ◽  
Polyunsaturated Fatty Acids ◽  
Fish Intake ◽  
Circulating Biomarkers ◽  
Heart Failure Trial

Lifecourse weight patterns and adult-onset diabetes: the Glasgow Alumni and British Women's Heart and Health studies

2005 ◽  
Vol 30 (3) ◽  
pp. 507-512 ◽  
Author(s):  
M Jeffreys ◽  
D A Lawlor ◽  
B Galobardes ◽  
P McCarron ◽  
S Kinra ◽  
...  
Keyword(s):  
Adult Onset ◽  
Onset Diabetes ◽  
Adult Onset Diabetes ◽  
Health Studies

Extrainsular mechanisms of glucose disposal in adult-onset diabetes

1971 ◽  
Vol 261 (4) ◽  
pp. 197-205
Author(s):  
MAXIMILIAN FABRYKANT ◽  
MAXWELL L. GELFAND ◽  
AURA A. ORTEGA ◽  
ERNEST R. BUFFONE ◽  
JOSE V. MANRIQUE
Keyword(s):  
Glucose Disposal ◽  
Adult Onset ◽  
Onset Diabetes ◽  
Adult Onset Diabetes
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