scholarly journals Type 2 Diabetes and COVID-19–Related Mortality in the Critical Care Setting: A National Cohort Study in England, March–July 2020

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 50-57 ◽  
Author(s):  
John M. Dennis ◽  
Bilal A. Mateen ◽  
Raphael Sonabend ◽  
Nicholas J. Thomas ◽  
Kashyap A. Patel ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Critical Care ◽  
Cohort Study ◽  
Care Setting ◽  
Critical Care Setting ◽  
National Cohort ◽  
Related Mortality

Diabetes and COVID-19 Related Mortality in the Critical Care Setting: A Real-Time National Cohort Study in England

2020 ◽  
Author(s):  
John M Dennis ◽  
Bilal A. Mateen ◽  
Raphael Sonabend ◽  
Nicholas J. Thomas ◽  
Kashyap A. Patel ◽  
...  
Keyword(s):  
Critical Care ◽  
Cohort Study ◽  
Real Time ◽  
Care Setting ◽  
Critical Care Setting ◽  
National Cohort ◽  
Related Mortality

scholarly journals Type 2 diabetes and COVID-19 related mortality in the critical care setting: A national cohort study in England, March-July 2020

2020 ◽  
Author(s):  
John M. Dennis ◽  
Bilal A Mateen ◽  
Raphael Sonabend ◽  
Nicholas J Thomas ◽  
Kashyap A Patel ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Critical Care ◽  
Cohort Study ◽  
Care Setting ◽  
Critical Care Setting ◽  
Risk Of Death ◽  
Risk Increase ◽  
Increased Risk ◽  
All Cause Mortality

<b>Objective: </b>To describe the relationship between type 2 diabetes and all-cause mortality amongst adults with COVID-19 in the critical care setting. <p><b>Research Design and Methods: </b>Nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between March 1, 2020 and July 27, 2020. Cox proportional hazards models were used to estimate 30 day in-hospital all-cause mortality associated with type 2 diabetes, adjusted for age, sex, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease).</p> <p><b>Results: </b>19,256 COVID-19 related HDU and ICU admissions were included in the primary analysis, including 13,809 HDU (mean age 70), and 5,447 ICU admissions (mean age 58). 3,524 (18.3%) had type 2 diabetes. 5,077 people (26.4%) died during the study period. People with type 2 diabetes were at increased risk of death (adjusted hazard ratio (aHR) 1.23 [95%CI 1.14;1.32]), results were consistent in HDU and ICU subsets. The relative mortality risk associated with type 2 diabetes decreased with increasing age (age 18-49 aHR 1.50 [95%CI 1.05;2.15]; age 50-64 1.29 [1.10;1.51]; age 65 or greater 1.18 [1.09;1.29], p-value for age:type 2 diabetes interaction 0.002).</p> <b>Conclusions: </b>Type 2 diabetes may be an independent prognostic factor for survival in people with severe COVID-19 requiring critical care treatment, and in this setting the risk increase associated with type 2 diabetes is greatest in younger people.<b><u><br> </u></b>

scholarly journals Type 2 diabetes and COVID-19 related mortality in the critical care setting: A national cohort study in England, March-July 2020

2020 ◽  
Author(s):  
John M. Dennis ◽  
Bilal A Mateen ◽  
Raphael Sonabend ◽  
Nicholas J Thomas ◽  
Kashyap A Patel ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Critical Care ◽  
Cohort Study ◽  
Care Setting ◽  
Critical Care Setting ◽  
Risk Of Death ◽  
Risk Increase ◽  
Increased Risk ◽  
All Cause Mortality

<b>Objective: </b>To describe the relationship between type 2 diabetes and all-cause mortality amongst adults with COVID-19 in the critical care setting. <p><b>Research Design and Methods: </b>Nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between March 1, 2020 and July 27, 2020. Cox proportional hazards models were used to estimate 30 day in-hospital all-cause mortality associated with type 2 diabetes, adjusted for age, sex, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease).</p> <p><b>Results: </b>19,256 COVID-19 related HDU and ICU admissions were included in the primary analysis, including 13,809 HDU (mean age 70), and 5,447 ICU admissions (mean age 58). 3,524 (18.3%) had type 2 diabetes. 5,077 people (26.4%) died during the study period. People with type 2 diabetes were at increased risk of death (adjusted hazard ratio (aHR) 1.23 [95%CI 1.14;1.32]), results were consistent in HDU and ICU subsets. The relative mortality risk associated with type 2 diabetes decreased with increasing age (age 18-49 aHR 1.50 [95%CI 1.05;2.15]; age 50-64 1.29 [1.10;1.51]; age 65 or greater 1.18 [1.09;1.29], p-value for age:type 2 diabetes interaction 0.002).</p> <b>Conclusions: </b>Type 2 diabetes may be an independent prognostic factor for survival in people with severe COVID-19 requiring critical care treatment, and in this setting the risk increase associated with type 2 diabetes is greatest in younger people.<b><u><br> </u></b>

scholarly journals Pioglitazone Reduces Mortality and Adverse Events in Patients With Type 2 Diabetes and With Advanced Chronic Kidney Disease: National Cohort Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. e152-e153 ◽  
Author(s):  
Chieh-Li Yen ◽  
Chao-Yi Wu ◽  
Lai-Chu See ◽  
Yi-Jung Li ◽  
Min-Hua Tseng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Adverse Events ◽  
Advanced Chronic Kidney Disease ◽  
National Cohort

Increased risk of site-specific cancer in people with type 2 diabetes: a national cohort study

2019 ◽  
Author(s):  
Linkeviciute-Ulinskiene Donata ◽  
Patasius Ausvydas ◽  
Zabuliene Lina ◽  
Smailyte Giedre
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Site Specific ◽  
Increased Risk ◽  
Specific Cancer ◽  
National Cohort

scholarly journals Preterm birth and risk of type 1 and type 2 diabetes: a national cohort study

Diabetologia ◽  
2019 ◽  
Vol 63 (3) ◽  
pp. 508-518 ◽  
Author(s):  
Casey Crump ◽  
Jan Sundquist ◽  
Kristina Sundquist
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Preterm Birth ◽  
Environmental Factors ◽  
Gestational Age ◽  
National Cohort

Abstract Aims/hypothesis Preterm birth (gestational age <37 weeks) has been associated with insulin resistance early in life. However, no large population-based studies have examined risks of type 1 and type 2 diabetes and potential sex-specific differences from childhood into adulthood. Clinicians will increasingly encounter adults who were born prematurely and will need to understand their long-term risks. We hypothesised that preterm birth is associated with increased risks of type 1 and type 2 diabetes into adulthood. Methods A national cohort study was conducted of all 4,193,069 singletons born in Sweden during 1973–2014, who were followed up for type 1 and type 2 diabetes identified from nationwide diagnoses and pharmacy data to the end of 2015 (maximum age 43 years; median age at the end of follow-up 22.5 years). Cox regression was used to adjust for potential confounders, and co-sibling analyses assessed the influence of shared familial (genetic and/or environmental) factors. Results In 92.3 million person-years of follow-up, 27,512 (0.7%) and 5525 (0.1%) people were identified with type 1 and type 2 diabetes, respectively. Gestational age at birth was inversely associated with both type 1 and type 2 diabetes risk. Adjusted HRs for type 1 and type 2 diabetes at age <18 years associated with preterm birth were 1.21 (95% CI, 1.14, 1.28) and 1.26 (95% CI, 1.01, 1.58), respectively, and at age 18–43 years were 1.24 (95% CI, 1.13, 1.37) and 1.49 (95% CI, 1.31, 1.68), respectively, compared with full-term birth. The associations between preterm birth and type 2 (but not type 1) diabetes were stronger among females (e.g. at age 18–43 years, females: adjusted HR, 1.75; 95% CI, 1.47, 2.09; males: 1.28; 95% CI, 1.08, 1.53; p < 0.01 for additive and multiplicative interaction). These associations were only partially explained by shared genetic or environmental factors in families. Conclusions/interpretation In this large national cohort, preterm birth was associated with increased risk of type 1 and type 2 diabetes from childhood into early to mid-adulthood. Preterm-born children and adults may need early preventive evaluation and long-term monitoring for diabetes.

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