scholarly journals Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 224-230
Author(s):  
Amra Jujić ◽  
Peter M. Nilsson ◽  
Naeimeh Atabaki-Pasdar ◽  
Anna Dieden ◽  
Tiinamaija Tuomi ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Normal Range ◽  
Media Thickness ◽  
Insulinotropic Peptide

scholarly journals Glucose-dependent insulinotropic peptide in the high normal range is associated with increased carotid intima-media thickness

2020 ◽  
Author(s):  
Amra Jujić ◽  
Peter M Nilsson ◽  
Naeimeh Atabaki-Pasdar ◽  
Anna Dieden ◽  
Tiinamaija Tuomi ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Total Mortality ◽  
Cardiovascular Effects ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Oral Glucose ◽  
Oral Glucose Tolerance Testing ◽  
Media Thickness ◽  
Insulinotropic Peptide

<b>Objective:</b> While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide-1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortality, and it was suggested that GIP plays a role in pathogenesis of coronary artery disease.. We investigated the associations between fasting and post-challenge GIP and GLP-1 concentrations and subclinical atherosclerosis as measured by intima-media thickness in the common carotid artery (IMT<sub>mean</sub>CCA), and intima-media thickness in the carotid bifurcation (IMT<sub>max</sub>Bulb). <p><b>Research design and methods: </b>Participants at re-examination within the Malmö Diet and Cancer cardiovascular cohort study (n=3734, mean age 72.5 years; 59.3% women; 10.8% subjects with diabetes; fasting GIP available for 3342 subjects; fasting GLP-1 available for 3299 subjects) underwent oral glucose tolerance testing and carotid ultrasound. </p> <p><b>Results: </b>In linear regression analyses, each 1 SD increment of fasting GIP was associated with increased (per mm) IMT<sub>mean</sub>CCA (β=0.010, p=0.010) and IMT<sub>max</sub>Bulb (β=0.014; p=0.040) in models adjusted for known risk factors and glucose metabolism. In contrast, each 1 SD increment of fasting GLP-1 was associated with decreased IMT<sub>max</sub>Bulb (per mm; β=-0.016, p=0.014). These associations remained significant when subjects with diabetes were excluded from analyses. </p> <p><b>Conclusion </b>In a Swedish elderly population, physiologically elevated levels of fasting GIP are associated with increased IMT<sub>mean</sub>CCA, while GLP-1 is associated with decreased IMT<sub>max</sub>Bulb, further emphasizing diverging cardiovascular effects of these two incretin hormones.</p>

scholarly journals Glucose-dependent insulinotropic peptide in the high normal range is associated with increased carotid intima-media thickness

2020 ◽  
Author(s):  
Amra Jujić ◽  
Peter M Nilsson ◽  
Naeimeh Atabaki-Pasdar ◽  
Anna Dieden ◽  
Tiinamaija Tuomi ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Total Mortality ◽  
Cardiovascular Effects ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Oral Glucose ◽  
Oral Glucose Tolerance Testing ◽  
Media Thickness ◽  
Insulinotropic Peptide

<b>Objective:</b> While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide-1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortality, and it was suggested that GIP plays a role in pathogenesis of coronary artery disease.. We investigated the associations between fasting and post-challenge GIP and GLP-1 concentrations and subclinical atherosclerosis as measured by intima-media thickness in the common carotid artery (IMT<sub>mean</sub>CCA), and intima-media thickness in the carotid bifurcation (IMT<sub>max</sub>Bulb). <p><b>Research design and methods: </b>Participants at re-examination within the Malmö Diet and Cancer cardiovascular cohort study (n=3734, mean age 72.5 years; 59.3% women; 10.8% subjects with diabetes; fasting GIP available for 3342 subjects; fasting GLP-1 available for 3299 subjects) underwent oral glucose tolerance testing and carotid ultrasound. </p> <p><b>Results: </b>In linear regression analyses, each 1 SD increment of fasting GIP was associated with increased (per mm) IMT<sub>mean</sub>CCA (β=0.010, p=0.010) and IMT<sub>max</sub>Bulb (β=0.014; p=0.040) in models adjusted for known risk factors and glucose metabolism. In contrast, each 1 SD increment of fasting GLP-1 was associated with decreased IMT<sub>max</sub>Bulb (per mm; β=-0.016, p=0.014). These associations remained significant when subjects with diabetes were excluded from analyses. </p> <p><b>Conclusion </b>In a Swedish elderly population, physiologically elevated levels of fasting GIP are associated with increased IMT<sub>mean</sub>CCA, while GLP-1 is associated with decreased IMT<sub>max</sub>Bulb, further emphasizing diverging cardiovascular effects of these two incretin hormones.</p>

Correlation of Serum Sclerostin Levels with Carotid Intima Media Thickness in Chronic Kidney Disease Hemodialysis

2020 ◽  
Vol 6 (1) ◽  
pp. 18-26
Author(s):  
Adhi Permana ◽  
Ian Effendi ◽  
Taufik Indrajaya
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Ultrasound Examination ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
The Mean ◽  
Sclerostin Level ◽  
Hemodialysis Duration

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.

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