scholarly journals A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes

Diabetes Care ◽  
2020 ◽  
pp. dc201232
Author(s):  
Emilie Palisaitis ◽  
Anas El Fathi ◽  
Julia E. von Oettingen ◽  
Ahmad Haidar ◽  
Laurent Legault
Keyword(s):  
Clinical Trial ◽  
Type 1 Diabetes ◽  
Artificial Pancreas ◽  
Detection Algorithm ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled

196-OR: A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents with Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 196-OR
Author(s):  
EMILIE PALISAITIS ◽  
ANAS EL FATHI ◽  
AHMAD HAIDAR ◽  
JULIA E. VON OETTINGEN ◽  
LAURENT LEGAULT
Keyword(s):  
Clinical Trial ◽  
Type 1 Diabetes ◽  
Artificial Pancreas ◽  
Detection Algorithm ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled

scholarly journals A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes

2020 ◽  
Author(s):  
Emilie Palisaitis ◽  
Anas El Fathi ◽  
Julia E. von Oettingen ◽  
Ahmad Haidar ◽  
Laurent Legault
Keyword(s):  
Crossover Trial ◽  
Artificial Pancreas ◽  
Detection Algorithm ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
The Past ◽  
Randomized Crossover Trial ◽  
Reduced Time

<a><b>Background</b>: We developed a meal detection algorithm for the artificial pancreas that detects unannounced meals and delivers an automatic insulin bolus.</a> <p> </p> <p><b>Methods</b>: We conducted a randomized crossover trial in 11 adolescents aged 12-18 years with HbA1c≥7.5% who missed≥1 bolus in the past six months. We compared (i) CSII, (ii) artificial pancreas (AP), and (iii) artificial pancreas with a meal detection algorithm (AP+MDA). Participants underwent three 9-hour interventions involving breakfast with a bolus and lunch without a bolus.</p> <p> </p> <p><b>Results</b>: In AP+MDA, the meal detection time was 40.0 [40.0–57.5] minutes. Compared to CSII, AP+MDA decreased the 4-hour post-lunch iAUC from 24.1±9.5 h.mmol/L to 15.4±8.0 h.mmol/L (p=0.03). iAUC did not differ between AP+MDA and AP (19.6±10.4 h.mmol/L, p=0.21) nor between AP and CSII (p=0.33). The AP+MDA reduced time>10mmol/L (58.0±26.6%) compared to CSII (79.6±27.5%, p=0.02) and AP (74.2±20.6%, p=0.047). </p> <p> </p> <p><b>Conclusions</b>: The AP+MDA improved glucose control after an unannounced meal.</p>

scholarly journals Randomized Controlled Clinical Trial of Glargine Versus Ultralente Insulin in the Treatment of Type 1 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 28 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Y. C. Kudva ◽  
A. Basu ◽  
G. D. Jenkins ◽  
G. M. Pons ◽  
L. L. Quandt ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Type 1 Diabetes ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled

scholarly journals A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes

2020 ◽  
Author(s):  
Emilie Palisaitis ◽  
Anas El Fathi ◽  
Julia E. von Oettingen ◽  
Ahmad Haidar ◽  
Laurent Legault
Keyword(s):  
Crossover Trial ◽  
Artificial Pancreas ◽  
Detection Algorithm ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
The Past ◽  
Randomized Crossover Trial ◽  
Reduced Time

<a><b>Background</b>: We developed a meal detection algorithm for the artificial pancreas that detects unannounced meals and delivers an automatic insulin bolus.</a> <p> </p> <p><b>Methods</b>: We conducted a randomized crossover trial in 11 adolescents aged 12-18 years with HbA1c≥7.5% who missed≥1 bolus in the past six months. We compared (i) CSII, (ii) artificial pancreas (AP), and (iii) artificial pancreas with a meal detection algorithm (AP+MDA). Participants underwent three 9-hour interventions involving breakfast with a bolus and lunch without a bolus.</p> <p> </p> <p><b>Results</b>: In AP+MDA, the meal detection time was 40.0 [40.0–57.5] minutes. Compared to CSII, AP+MDA decreased the 4-hour post-lunch iAUC from 24.1±9.5 h.mmol/L to 15.4±8.0 h.mmol/L (p=0.03). iAUC did not differ between AP+MDA and AP (19.6±10.4 h.mmol/L, p=0.21) nor between AP and CSII (p=0.33). The AP+MDA reduced time>10mmol/L (58.0±26.6%) compared to CSII (79.6±27.5%, p=0.02) and AP (74.2±20.6%, p=0.047). </p> <p> </p> <p><b>Conclusions</b>: The AP+MDA improved glucose control after an unannounced meal.</p>

Sign in / Sign up

Export Citation Format

Share Document